DRSC/TRiP Functional Genomics Resources

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Protein Alignment Prdm13 and ZNF407

DIOPT Version :9

Sequence 1:NP_648032.1 Gene:Prdm13 / 38713 FlyBaseID:FBgn0035687 Length:465 Species:Drosophila melanogaster
Sequence 2:NP_001371404.1 Gene:ZNF407 / 55628 HGNCID:19904 Length:2248 Species:Homo sapiens


Alignment Length:403 Identity:78/403 - (19%)
Similarity:124/403 - (30%) Gaps:162/403 - (40%)


- Green bases have known domain annotations that are detailed below.


  Fly   104 LSNGELIVSGSLLRQIKLSED--------------------------VYSFNAIFELHGGQVRVR 142
            |.|.|::::.....:..|.||                          :|||        |:....
Human  1303 LGNKEILMNSQHETEFILEEDGPASDSTVESSDVYETIISIDDKGQAMYSF--------GRFDSS 1359

  Fly   143 LVRDVAREDEIVAWFGEELVLLMGIPFL-TPL---------------NIQGNSRYMCHLCHLTFE 191
            ::|....||..:....||.::..|:... .||               :|..::|..|..|....:
Human  1360 IIRIKNPEDGELIDQSEEGLIATGVRISELPLKDCAQGVKKKKSEGSSIGESTRIRCDDCGFLAD 1424

  Fly   192 TPHPLKIHLA------------LGCGRSAMDILWMRLHYALKAAARSHTETQHSPIPATSSTSSA 244
            ....|.:|:|            |.||:|.  .....||..|  |:..|...:.:.:         
Human  1425 GLSGLNVHIAMKHPTKEKHFHCLLCGKSF--YTESNLHQHL--ASAGHMRNEQASV--------- 1476

  Fly   245 SPTHSPPPQMPPRFSAFRPIAALTQSLPMVPVTTAATPLSYLPSMSMATAPLSTNP---MNAAAQ 306
                   .::|...:.|:.:                          ..|.|..:..   ::...|
Human  1477 -------EELPEGGATFKCV--------------------------KCTEPFDSEQNLFLHIKGQ 1508

  Fly   307 IEAIVSNMG--------------ASKQGHLCIYCGKV--YSRKYGLKIHIRTHTGFKPLKCKFC- 354
            .|.::..:.              ...||::|.||||:  .|.......|||||||.||.|||.| 
Human  1509 HEELLREVNKYIVEDTEQINREREENQGNVCKYCGKMCRSSNSMAFLAHIRTHTGSKPFKCKICH 1573

  Fly   355 --LRPFGDPSNLNKHVRLHLQTHPSSSAGVADGGASGADMDGDVDIEGETDADYQCHVCHKSFPR 417
              ....||..|   ||:.||...                             :|:||||..:|..
Human  1574 FATAQLGDARN---HVKRHLGMR-----------------------------EYKCHVCGVAFVM 1606

  Fly   418 RRDLQRHMETRHG 430
            ::.|..|:..:||
Human  1607 KKHLNTHLLGKHG 1619

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Prdm13NP_648032.1 COG5048 280..>380 CDD:227381 32/121 (26%)
C2H2 Zn finger 323..343 CDD:275368 9/21 (43%)
zf-H2C2_2 336..358 CDD:290200 13/24 (54%)
C2H2 Zn finger 351..371 CDD:275368 8/22 (36%)
zf-C2H2 406..427 CDD:278523 8/20 (40%)
C2H2 Zn finger 408..427 CDD:275368 7/18 (39%)
ZNF407NP_001371404.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..84
C2H2 Zn finger 188..208 CDD:275368
C2H2 Zn finger 217..238 CDD:275368
C2H2 Zn finger 246..268 CDD:275368
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 291..322
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 494..515
C2H2 Zn finger 590..614 CDD:275371
C2H2 Zn finger 617..639 CDD:275371
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 667..700
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 821..847
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 910..962
C2H2 Zn finger 1416..1445 CDD:275371 5/28 (18%)
C2H2 Zn finger 1446..1468 CDD:275371 8/25 (32%)
C2H2 Zn finger 1488..1509 CDD:275371 2/46 (4%)
C2H2 Zn finger 1539..1561 CDD:275368 9/21 (43%)
zf-H2C2_2 1557..1578 CDD:404364 13/20 (65%)
C2H2 Zn finger 1569..1589 CDD:275368 8/22 (36%)
C2H2 Zn finger 1597..1617 CDD:275368 7/19 (37%)
C2H2 Zn finger 1630..1650 CDD:275368
zf-H2C2_2 1642..1669 CDD:404364
C2H2 Zn finger 1658..1680 CDD:275368
C2H2 Zn finger 1688..1708 CDD:275368
zf-H2C2_2 1700..1725 CDD:404364
zf-H2C2_5 1714..1738 CDD:404746
C2H2 Zn finger 1716..1736 CDD:275368
zf-H2C2_2 1728..1753 CDD:404364
C2H2 Zn finger 1744..1761 CDD:275368
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR24403
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
22.010

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