DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Prdm13 and prdm9

DIOPT Version :9

Sequence 1:	NP_648032.1	Gene:	Prdm13 / 38713	FlyBaseID:	FBgn0035687	Length:	465	Species:	Drosophila melanogaster
Sequence 2:	NP_957196.1	Gene:	prdm9 / 393876	ZFINID:	ZDB-GENE-040426-1319	Length:	853	Species:	Danio rerio

Alignment Length:	329	Identity:	85/329 - (25%)
Similarity:	107/329 - (32%)	Gaps:	93/329 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   176 QGNSRYMCHLCHLTFETPHPLKIHLALGCGRSAMDILWMRLHYALKAAARSHTETQHS---PIPA 237
            |..|:|:|..|...|.....||.|..:..|..:.......|::......|.|..|.||   |...
Zfish   542 QEASQYICGECIRAFSNLDLLKAHECIQQGEGSYCCPHCDLYFNRMCNLRRHERTIHSKEKPYCC 606

  Fly   238 T-----SSTSSASPTHSPPPQMPPRFSAFRPIAALTQSLPMVPVTTAATPLSYL----------- 286
            |     .:.||....|.   |...|..:.|..:||        .|.|..|.:|.
Zfish   607 TVCLKSFTQSSGLKRHQ---QSHLRRKSHRQSSAL--------FTAAIFPCAYCPFSFTDERYLY 660

  Fly   287 -------PSMSM------ATAPLSTNPMNAAAQIEAIVS------NMGASKQG---HLCIYCGKV 329
                   |.||:      ....||....::.:|.....|      |....|||   :||..|||.
Zfish   661 KHIRRHHPEMSLKYLSFQEGGVLSVEKPHSCSQCCKSFSTIKGFKNHSCFKQGEKVYLCPDCGKA 725

  Fly   330 YSRKYGLKIHIRTHTGFKPLKCKFCLRPFGDPSNLNKHVRLH--------------------LQT 374
            :|....||.|.|.|||.||..|..|.:.|.....||.|:|.|                    |:.
Zfish   726 FSWFNSLKQHQRIHTGEKPYTCSQCGKSFVHSGQLNVHLRTHTGEKPFLCSQCGESFRQSGDLRR 790

  Fly   375 HPSSSAGV-----ADGGASGADMDGDVDIEGETDADYQCHV---------CHKSFPRRRDLQRHM 425
            |....:||     .|.|.|.:...       ...|..|.||         |.|||.||..|.||.
Zfish   791 HEQKHSGVRPCQCPDCGKSFSRPQ-------SLKAHQQLHVGTKLFPCTQCGKSFTRRYHLTRHH 848

  Fly   426 ETRH 429
            :..|
Zfish   849 QKMH 852

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Prdm13	NP_648032.1	COG5048	280..>380	CDD:227381	38/152 (25%)
		C2H2 Zn finger	323..343	CDD:275368	9/19 (47%)
		zf-H2C2_2	336..358	CDD:290200	11/21 (52%)
		C2H2 Zn finger	351..371	CDD:275368	7/19 (37%)
		zf-C2H2	406..427	CDD:278523	12/29 (41%)
		C2H2 Zn finger	408..427	CDD:275368	11/27 (41%)
prdm9	NP_957196.1	PR-SET_PRDM7_9	79..207	CDD:380970
		Substrate binding. /evidence=ECO:0000250\|UniProtKB:Q96EQ9	127..133
		S-adenosyl-L-methionine binding. /evidence=ECO:0000250\|UniProtKB:Q96EQ9	275..277
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	291..322
		COG5048	333..755	CDD:227381	58/223 (26%)
		C2H2 Zn finger	339..360	CDD:275368
		S-adenosyl-L-methionine binding. /evidence=ECO:0000250\|UniProtKB:Q96EQ9	341..342
		C2H2 Zn finger	368..388	CDD:275368
		C2H2 Zn finger	407..427	CDD:275368
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	447..496
		C2H2 Zn finger	549..569	CDD:275368	6/19 (32%)
		C2H2 Zn finger	577..598	CDD:275368	4/20 (20%)
		C2H2 Zn finger	606..626	CDD:275368	5/22 (23%)
		C2H2 Zn finger	646..666	CDD:275368	1/19 (5%)
		COG5048	<687..849	CDD:227381	49/168 (29%)
		C2H2 Zn finger	691..711	CDD:275368	3/19 (16%)
		C2H2 Zn finger	719..739	CDD:275368	9/19 (47%)
		C2H2 Zn finger	747..767	CDD:275368	7/19 (37%)
		DNA-binding. /evidence=ECO:0000250\|UniProtKB:Q9NQV7	755..845		22/96 (23%)
		C2H2 Zn finger	775..795	CDD:275368	2/19 (11%)
		C2H2 Zn finger	803..823	CDD:275368	5/26 (19%)
		C2H2 Zn finger	831..852	CDD:275368	9/20 (45%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24403
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.100