DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Prdm13 and Zfp462

DIOPT Version :9

Sequence 1:	NP_648032.1	Gene:	Prdm13 / 38713	FlyBaseID:	FBgn0035687	Length:	465	Species:	Drosophila melanogaster
Sequence 2:	XP_038966959.1	Gene:	Zfp462 / 362522	RGDID:	1562123	Length:	2565	Species:	Rattus norvegicus

Alignment Length:	427	Identity:	80/427 - (18%)
Similarity:	136/427 - (31%)	Gaps:	175/427 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly    53 SPAKRMRMSNPRPGVYASQYTPKDTCSMAIPTSALLGSTVMPTDGSRSHCQLSNGELIVSGSLLR 117
            ||.|.:.:::..|.:.::.|    .|            ||..::.:..|..|::......|..::
  Rat  1449 SPEKSIHLASANPAISSTPY----QC------------TVCQSEYNNLHGLLTHYGKKHPGMKVK 1497

  Fly   118 QIKLSEDV-YSFNAIFE----------LHG---------GQVRVR---LVRDVAREDEIVAWFGE 159
            ....::|| .:..|:::          :||         ..::|.   .|.||.:..:|.....|
  Rat  1498 AADFAQDVDINPGAVYKCRHCPYINTRIHGVLTHYQKRHPAIKVTAEDFVHDVEQSADITQNDVE 1562

  Fly   160 ELVLLMGIPFLTPLNIQGNSRYMCHLCHLTFETPHPLKIHLALGCGRSAMDILWMRLHYALKAAA 224
            |...:..         ||...|.|.||..|..|...||||.
  Rat  1563 ETSRIFK---------QGYGAYRCKLCPYTHGTLEKLKIHY------------------------ 1594

  Fly   225 RSHTETQHSPIPATSSTSSASPTHSPPPQMPPRFSAFRPIAALTQSLPMVPV------TTAATPL 283
                |..|:                     .|.|..|.|      |.|.:||      ||..:|
  Rat  1595 ----EKYHN---------------------QPEFDVFSP------SPPKLPVSLEPEITTEVSP- 1627

  Fly   284 SYLPSMSMATAPLSTNPMNAAAQIEAIVSNMGASKQGHLCIYCGKVYSRKYGLKIHIRTHTGFKP 348
               ..:||....:..:||:.|        :...|                     |:.:||.|:.
  Rat  1628 ---SQVSMTEEEVGEDPMSTA--------HFSTS---------------------HLVSHTVFRC 1660

  Fly   349 LKCK-FCLRPFGDPSNLNKHVRL---HLQTHPSSSAGVADGGASGADMDGDVDIEGETDADYQCH 409
            ..|| ||....|    :.:|.|:   :::..|                      ||:.:. ::|.
  Rat  1661 QLCKYFCSTRKG----IARHYRIKHNNVRAQP----------------------EGKNNL-FKCA 1698

  Fly   410 VCHKSFPRRRDLQRHMETRH--GGHHSHSHSESRSSS 444
            :|..:.|.|:.|..|.:.||  ..:::|..:.||:.|
  Rat  1699 LCAYTNPIRKGLAAHYQKRHDIDAYYTHCLAASRTIS 1735

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Prdm13	NP_648032.1	COG5048	280..>380	CDD:227381	19/103 (18%)
		C2H2 Zn finger	323..343	CDD:275368	1/19 (5%)
		zf-H2C2_2	336..358	CDD:290200	8/22 (36%)
		C2H2 Zn finger	351..371	CDD:275368	7/23 (30%)
		zf-C2H2	406..427	CDD:278523	6/20 (30%)
		C2H2 Zn finger	408..427	CDD:275368	6/18 (33%)
Zfp462	XP_038966959.1	C2H2 Zn finger	2052..2072	CDD:275368
		zf-H2C2_5	2084..2108	CDD:404746
		C2H2 Zn finger	2086..2106	CDD:275368
		C2H2 Zn finger	2115..2136	CDD:275368
		C2H2 Zn finger	2144..2165	CDD:275368
		C2H2 Zn finger	2315..2335	CDD:275368
		C2H2 Zn finger	2361..2381	CDD:275368
		C2H2 Zn finger	2389..2410	CDD:275368
		C2H2 Zn finger	2475..2495	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24403
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100