DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Prdm13 and Zfp646

DIOPT Version :9

Sequence 1:	NP_648032.1	Gene:	Prdm13 / 38713	FlyBaseID:	FBgn0035687	Length:	465	Species:	Drosophila melanogaster
Sequence 2:	NP_766337.2	Gene:	Zfp646 / 233905	MGIID:	3665412	Length:	1788	Species:	Mus musculus

Alignment Length:	352	Identity:	79/352 - (22%)
Similarity:	118/352 - (33%)	Gaps:	109/352 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   148 AREDEIVAWFGEELVLLMGIPF---LTPLNIQGNSR------YMCHLCHLTFETPHPLKIHLALG 203
            |::|      |||   ..|||.   ..|.|:..:.|      :.|..|...|.....|:.|:...
Mouse    34 AKQD------GEE---ADGIPHPYGSHPENLANHQRNHETLFFPCTTCGKDFSNRLALQSHMRTH 89

  Fly   204 CGRSAMDILWMRLH---YALKAAARSHTETQHSPIPATSS--------------TSSASPTHSPP 251
            ...|      .|.|   :|::.|....:||.     ||.|              |.....||...
Mouse    90 APES------HRRHGPPHAMETAPHLGSETM-----ATDSWGQRLGSGEGWENQTKLVRETHDWE 143

  Fly   252 PQMPPRFSAFR---PIAALTQSLPMVPVTTAATPLSYLPSMSM-ATAPLSTNPMNAAAQI----- 307
            ....||.::..   |.....|.|.|.|.:...| ..::|::|. ..:||.|...|..:.:
Mouse   144 SGADPRAASGTWEDPPTKQRQGLEMQPDSKGGT-ADWVPAVSSEGASPLPTPASNLLSNLEQYLA 207

  Fly   308 EAIVSNMGA----------SKQGHLCIYCGKVYSRKYGLKIHIRTHT-GFKPLKCKFCLRPFGDP 361
            |::|:...|          .::.:.|..|||.|.....|..|.::|| |..|  |..|.:.|.:.
Mouse   208 ESVVNFTEAQEPTEPLPTEGERKYRCSECGKTYKHAGSLTNHRQSHTLGIYP--CSICFKEFSNL 270

  Fly   362 SNLNKHVRLHLQTHPSSSAGVADGGASGADMDGDVDIEGETDADYQCHVCHKSFPRRRDLQRHME 426
            ..|..|.|||.|..|                             |.|..|.::|...|||..|.:
Mouse   271 MALKNHSRLHAQYRP-----------------------------YHCPHCPRAFRLPRDLLEHQQ 306

  Fly   427 TRHGGHH-----------SHSHSESRS 442
            :..|...           ::.|::.||
Mouse   307 SHEGLKQEQPWEDKEMPTTNGHADERS 333

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Prdm13	NP_648032.1	COG5048	280..>380	CDD:227381	31/116 (27%)
		C2H2 Zn finger	323..343	CDD:275368	7/19 (37%)
		zf-H2C2_2	336..358	CDD:290200	8/22 (36%)
		C2H2 Zn finger	351..371	CDD:275368	6/19 (32%)
		zf-C2H2	406..427	CDD:278523	8/20 (40%)
		C2H2 Zn finger	408..427	CDD:275368	7/18 (39%)
Zfp646	NP_766337.2	C2H2 Zn finger	10..31	CDD:275368
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	28..48		8/22 (36%)
		C2H2 Zn finger	69..89	CDD:275368	5/19 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	139..196		15/57 (26%)
		C2H2 Zn finger	233..253	CDD:275368	7/19 (37%)
		C2H2 Zn finger	260..280	CDD:275368	6/19 (32%)
		C2H2 Zn finger	288..308	CDD:275368	7/19 (37%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	306..360		4/28 (14%)
		C2H2 Zn finger	368..388	CDD:275368
		C2H2 Zn finger	395..415	CDD:275368
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	416..449
		C2H2 Zn finger	459..479	CDD:275368
		C2H2 Zn finger	486..506	CDD:275368
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	509..531
		C2H2 Zn finger	568..588	CDD:275368
		C2H2 Zn finger	608..628	CDD:275368
		C2H2 Zn finger	635..655	CDD:275368
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	651..712
		C2H2 Zn finger	808..828	CDD:275368
		C2H2 Zn finger	835..855	CDD:275368
		C2H2 Zn finger	868..886	CDD:275368
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	889..916
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	956..976
		C2H2 Zn finger	1037..1057	CDD:275368
		C2H2 Zn finger	1064..1084	CDD:275368
		C2H2 Zn finger	1172..1192	CDD:275368
		C2H2 Zn finger	1199..1219	CDD:275368
		C2H2 Zn finger	1227..1247	CDD:275368
		C2H2 Zn finger	1268..1285	CDD:275368
		C2H2 Zn finger	1295..1315	CDD:275368
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1351..1386
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1398..1439
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1455..1489
		C2H2 Zn finger	1500..1518	CDD:275368
		C2H2 Zn finger	1526..1544	CDD:275368
		C2H2 Zn finger	1552..1572	CDD:275368
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1579..1629
		C2H2 Zn finger	1642..1662	CDD:275368
		C2H2 Zn finger	1669..1689	CDD:275368
		zf-H2C2_2	1681..1706	CDD:372612
		C2H2 Zn finger	1697..1717	CDD:275368
		C2H2 Zn finger	1726..1746	CDD:275368
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1744..1788
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24403
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100