DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Prdm13 and znf335

DIOPT Version :9

Sequence 1:	NP_648032.1	Gene:	Prdm13 / 38713	FlyBaseID:	FBgn0035687	Length:	465	Species:	Drosophila melanogaster
Sequence 2:	XP_005167155.1	Gene:	znf335 / 100148891	ZFINID:	ZDB-GENE-130530-814	Length:	1534	Species:	Danio rerio

Alignment Length:	290	Identity:	55/290 - (18%)
Similarity:	98/290 - (33%)	Gaps:	69/290 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   168 PFLTPLNIQGNSRYMCHLCHLTFETPHPLKIHLALGCGRSAMDILWMRLHYALK--AAARSH--- 227
            |.|.|.|        |.:|...|.:...||.|:....|........::..|..|  ::.:.|
Zfish   692 PLLRPHN--------CWICGSRFLSQEDLKFHVDSHEGNDPERYKCLQCSYRCKRWSSLKEHMFN 748

  Fly   228 --------------------TETQHSPIPATSSTSSASPTHSPPPQMPPRFSAFRPIAALTQSLP 272
                                ..|:||.:...|.:.....:...|.|: .:.|.|
Zfish   749 HEGTKPYKCEMCDYTSVYKKDVTRHSAVHNKSKSRKIDVSCVNPSQV-SKVSEF----------- 801

  Fly   273 MVPVTTAATPLSYLPSMSMATAPLSTNPMNAAAQIEAIVSNMGASKQGHLCIYCGKVYSRKYGLK 337
            ..|:.:...|:....:..|.|                     .::::.|:|..|||.:.::|..|
Zfish   802 PCPICSRVYPMQKRLTQHMKT---------------------HSTEKPHMCDKCGKSFKKRYTFK 845

  Fly   338 IHIRTH---TGFKPLKCKFCLRPFGDPSNLNKHVRLHLQTHPSSSAGVADGGASGADMDGDVDIE 399
            :|:.||   .|....||:||.....|..:|..|...|....|..........:....:...:.|:
Zfish   846 MHLLTHIQNCGNSLFKCEFCDYTCNDKKHLLNHQLSHTNDKPFKCEECKYSTSKEDFLVSHIAIK 910

  Fly   400 GETDADYQCHVCHKSFPRRRDLQRHMETRH 429
            ...:..:.|.:||.:...|::|:.|::.||
Zfish   911 HTGEKPFSCEMCHFTTRHRKNLRLHVQCRH 940

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Prdm13	NP_648032.1	COG5048	280..>380	CDD:227381	23/102 (23%)
		C2H2 Zn finger	323..343	CDD:275368	7/19 (37%)
		zf-H2C2_2	336..358	CDD:290200	9/24 (38%)
		C2H2 Zn finger	351..371	CDD:275368	6/19 (32%)
		zf-C2H2	406..427	CDD:278523	6/20 (30%)
		C2H2 Zn finger	408..427	CDD:275368	6/18 (33%)
znf335	XP_005167155.1	COG5048	<592..838	CDD:227381	31/186 (17%)
		C2H2 Zn finger	699..719	CDD:275368	6/19 (32%)
		C2H2 Zn finger	729..749	CDD:275368	3/19 (16%)
		zf-H2C2_2	741..766	CDD:290200	1/24 (4%)
		C2H2 Zn finger	803..823	CDD:275368	4/40 (10%)
		zf-H2C2_2	816..839	CDD:290200	7/43 (16%)
		zf-C2H2	829..851	CDD:278523	8/21 (38%)
		C2H2 Zn finger	831..851	CDD:275368	7/19 (37%)
		C2H2 Zn finger	862..882	CDD:275368	6/19 (32%)
		zf-H2C2_2	874..898	CDD:290200	4/23 (17%)
		C2H2 Zn finger	890..911	CDD:275368	1/20 (5%)
		C2H2 Zn finger	919..936	CDD:275368	5/16 (31%)
		C2H2 Zn finger	1215..1235	CDD:275370
		C2H2 Zn finger	1243..1263	CDD:275368
		C2H2 Zn finger	1271..1291	CDD:275368
		zf-H2C2_2	1283..1308	CDD:290200
		C2H2 Zn finger	1299..1320	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24403
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.100