DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cpr65Az and KALRN

DIOPT Version :9

Sequence 1:	NP_648031.1	Gene:	Cpr65Az / 38712	FlyBaseID:	FBgn0035686	Length:	239	Species:	Drosophila melanogaster
Sequence 2:	XP_006713873.1	Gene:	KALRN / 8997	HGNCID:	4814	Length:	2988	Species:	Homo sapiens

Alignment Length:	234	Identity:	52/234 - (22%)
Similarity:	70/234 - (29%)	Gaps:	80/234 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 VRSQPAGYPSARPPATYLPVKPPAPPPRPPPPAPANSYGPPKKGNGKPPPAPPKPSYGPPPKNGN 81
            :|||||..|.|              .|||....||.|..|||..:..||..|.|.|      ..|
Human  2253 MRSQPARLPQA--------------SPRPYSSVPAGSEKPPKGSSYNPPLPPLKIS------TSN 2297

  Fly    82 GKPPPSNAYLPPGNGNGGSSGGGGAGGGGGEDIPIIKLESKVNTDGSYMYEYETGNGIKAEEMGY 146
            |.  |...|..||:....|......|..|...:.:||             :|   ..:|..|:
Human  2298 GS--PGFEYHQPGDKFEASKQNDLGGCNGTSSMAVIK-------------DY---YALKENEI-- 2342

  Fly   147 LKNAGVEGAEAQTAEGSFSYTSPEGQEISLTYIADEN---GFQPQGDHLPTPPP-IPIEIQEALD 207
                                ...:|:.:.:..:..:|   .:||..||.|.... :|..|...|.
Human  2343 --------------------CVSQGEVVQVLAVNQQNMCLVYQPASDHSPAAEGWVPGSILAPLT 2387

  Fly   208 KLAAGGGCHG----------------CDDNETGGNDDGG 230
            |..|.....|                .:...||.|:..|
Human  2388 KATAAESSDGSIKKSCSWHTLRMRKRAEVENTGKNEATG 2426

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cpr65Az	NP_648031.1	Chitin_bind_4	129..185	CDD:278791	5/58 (9%)
KALRN	XP_006713873.1	SEC14	41..179	CDD:214706
		SPEC	192..412	CDD:238103
		SPEC	313..538	CDD:238103
		SPEC	539..768	CDD:238103
		SPEC	893..1131	CDD:238103
		SPEC	<1101..1240	CDD:295325
		RhoGEF	1286..1456	CDD:238091
		PH1_Kalirin_Trio_like	1463..1585	CDD:270060
		PH	1496..1581	CDD:278594
		SH3_Kalirin_1	1651..1710	CDD:212786
		SH3-RhoG_link	1708..1934	CDD:293215
		RhoGEF	1935..2105	CDD:279015
		PH2_Kalirin_Trio_p63RhoGEF	2109..2243	CDD:270061
		PH	2142..2228	CDD:278594
		SH3_Kalirin_2	2327..2385	CDD:212787	14/95 (15%)
		I-set	2473..2567	CDD:254352
		Ig	2490..2564	CDD:143165
		FN3	2571..2662	CDD:238020
		S_TKc	2686..2940	CDD:214567
		STKc_Kalirin_C	2692..2939	CDD:271017
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910