DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ZKSCAN4 and CG18764

DIOPT Version :9

Sequence 1:	NP_061983.2	Gene:	ZKSCAN4 / 387032	HGNCID:	13854	Length:	545	Species:	Homo sapiens
Sequence 2:	NP_652712.2	Gene:	CG18764 / 59239	FlyBaseID:	FBgn0042205	Length:	409	Species:	Drosophila melanogaster

Alignment Length:	148	Identity:	61/148 - (41%)
Similarity:	81/148 - (54%)	Gaps:	8/148 - (5%)

- Green bases have known domain annotations that are detailed below.

Human   306 RLQRKQKNAIGSRRHYCHECGKSFAQSSGLTKHRRIHTGEKPYECEDCGKTFIGSSALVIHQR-V 369
            |||||       |...|.:||:.|...|....|...|||.|.:.|:.|||.|.....:.:||| :
  Fly   251 RLQRK-------RECVCEQCGRQFTDQSNFKLHMLRHTGNKNFACQQCGKRFYTDHLMTLHQRII 308

Human   370 HTGEKPYECEECGKVFSHSSNLIKHQRTHTGEKPYECDDCGKTFSQSCSLLEHHKIHTGEKPYQC 434
            |.|||||:|..|.|.|.:|:..:.|:||||..|||.|..|.|.|..:.....|..||||.:.:.|
  Fly   309 HQGEKPYDCRFCTKSFHNSNTRLIHERTHTNAKPYSCHHCDKCFKSASGRKRHELIHTGVRAFAC 373

Human   435 NMCGKAFRRNSHLLRHQR 452
            .:|.::|:||:||..|.|
  Fly   374 TICKQSFQRNTHLKAHLR 391

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ZKSCAN4	NP_061983.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..22
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	34..55
		SCAN	49..160	CDD:128708
		KRAB	221..281	CDD:214630
		zf-C2H2	320..342	CDD:306579	6/21 (29%)
		C2H2 Zn finger	322..342	CDD:275368	6/19 (32%)
		zf-H2C2_2	335..357	CDD:316026	9/21 (43%)
		C2H2 Zn finger	350..370	CDD:275368	8/20 (40%)
		COG5048	<374..544	CDD:227381	34/79 (43%)
		C2H2 Zn finger	378..398	CDD:275368	7/19 (37%)
		C2H2 Zn finger	406..426	CDD:275368	5/19 (26%)
		C2H2 Zn finger	434..454	CDD:275368	9/19 (47%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	455..480
		C2H2 Zn finger	489..509	CDD:275368
		C2H2 Zn finger	517..537	CDD:275368
CG18764	NP_652712.2	zf-AD	4..75	CDD:214871
		C2H2 Zn finger	260..280	CDD:275368	6/19 (32%)
		zf-H2C2_2	272..297	CDD:290200	10/24 (42%)
		C2H2 Zn finger	288..309	CDD:275368	8/20 (40%)
		C2H2 Zn finger	317..337	CDD:275368	7/19 (37%)
		C2H2 Zn finger	345..365	CDD:275368	5/19 (26%)
		C2H2 Zn finger	373..391	CDD:275368	8/17 (47%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	123	1.000	Inparanoid score	I4733
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.960