DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ZKSCAN4 and si:dkeyp-35e5.9

DIOPT Version :9

Sequence 1:	NP_061983.2	Gene:	ZKSCAN4 / 387032	HGNCID:	13854	Length:	545	Species:	Homo sapiens
Sequence 2:	XP_017211231.1	Gene:	si:dkeyp-35e5.9 / 108183931	ZFINID:	ZDB-GENE-110913-107	Length:	325	Species:	Danio rerio

Alignment Length:	305	Identity:	112/305 - (36%)
Similarity:	147/305 - (48%)	Gaps:	53/305 - (17%)

- Green bases have known domain annotations that are detailed below.

Human   249 KQENHSSLVSLGGEIQTKSRDLPPV-------------KKLPEKEHGKICHLREDIAQIPTHAEA 300
            |||:..  |.:....:.|..||...             .::.||:|.:|     ...:.||..:.
Zfish     5 KQESED--VKIEDTFRVKQEDLQEQTDLMVLKEETHQWNEMEEKKHQEI-----TTDEKPTLTKK 62

Human   301 GEQEGRLQRKQKNAIGSRRHYCHECGKSFAQSSGLTKHRRIHTGEKPYECEDCGKTFIGSSALVI 365
            ....|| .||.|:..   ...|..|.|||:|.|.|..|.|:|||||||.|:.|||:|.....|.:
Zfish    63 TSSRGR-PRKSKSGC---NFSCKRCRKSFSQRSNLDVHMRVHTGEKPYTCKQCGKSFYTIGNLTV 123

Human   366 HQRVHTGEKPYECEECGKVFSHSSNLIKHQRTHTGEKPYECDDCGKTFSQSCSLLEHHKIHTGEK 430
            |.|:||||:||.|::|||.|..:.||..|.|.|||||||.|..|||::.|:.:|..|.:.||||:
Zfish   124 HMRIHTGERPYACQKCGKSFYTTGNLAAHMRIHTGEKPYSCLQCGKSYKQNGNLEVHMRTHTGER 188

Human   431 PYQCNMCGKAFRRNSHLLRHQRIH-GDKNVQNPEHGESWESQGRTESQWENTEAPVSYKCNECER 494
            .:.|..|||.|.:..:|..|.||| |:|                            .|.|.||.:
Zfish   189 SFICTQCGKGFSQKQNLTIHMRIHTGEK----------------------------PYTCTECGK 225

Human   495 SFTRNRSLIEHQKIHTGEKPYQCDTCGKGFTRTSYLVQHQRSHVG 539
            ||....:|..|...||||||:.|..|||.||..:.|:.|...|.|
Zfish   226 SFRCKNTLDHHMISHTGEKPFACAHCGKSFTTKARLMNHTNGHTG 270

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ZKSCAN4	NP_061983.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..22
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	34..55
		SCAN	49..160	CDD:128708
		KRAB	221..281	CDD:214630	9/44 (20%)
		zf-C2H2	320..342	CDD:306579	10/21 (48%)
		C2H2 Zn finger	322..342	CDD:275368	10/19 (53%)
		zf-H2C2_2	335..357	CDD:316026	14/21 (67%)
		C2H2 Zn finger	350..370	CDD:275368	8/19 (42%)
		COG5048	<374..544	CDD:227381	65/167 (39%)
		C2H2 Zn finger	378..398	CDD:275368	9/19 (47%)
		C2H2 Zn finger	406..426	CDD:275368	7/19 (37%)
		C2H2 Zn finger	434..454	CDD:275368	8/19 (42%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	455..480		2/24 (8%)
		C2H2 Zn finger	489..509	CDD:275368	7/19 (37%)
		C2H2 Zn finger	517..537	CDD:275368	8/19 (42%)
si:dkeyp-35e5.9	XP_017211231.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	212	1.000	Inparanoid score	I10838
NCBI	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.960