DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ZKSCAN4 and si:dkey-122c11.8

DIOPT Version :9

Sequence 1:	NP_061983.2	Gene:	ZKSCAN4 / 387032	HGNCID:	13854	Length:	545	Species:	Homo sapiens
Sequence 2:	XP_017211097.1	Gene:	si:dkey-122c11.8 / 108183696	ZFINID:	ZDB-GENE-110913-23	Length:	358	Species:	Danio rerio

Alignment Length:	338	Identity:	116/338 - (34%)
Similarity:	159/338 - (47%)	Gaps:	76/338 - (22%)

- Green bases have known domain annotations that are detailed below.

Human   205 EDAMVASRLTPGSQGLLKMEDVALTLTPGWTQLDSSQVNLYRDEKQENHSSLVSLGGEIQTKSRD 269
            ||..:....|...:.|.:..|:.|.                   |::.|..     .|::.|.:|
Zfish     9 EDVKIEETFTVKQEDLQEQTDLMLL-------------------KEKTHQQ-----NEMEEKQQD 49

Human   270 LPPVKKLPEKEHGKICHLREDIAQIPTHAEAGEQEGRLQRKQKNAIGSRRHY-CHECGKSFAQSS 333
            :...:|                   ||..:.....|| .||.|    .|.:: |.:|||||:|..
Zfish    50 MTTDEK-------------------PTLTKKTLSRGR-PRKSK----PRCNFSCKQCGKSFSQKP 90

Human   334 GLTKHRRIHTGEKPYECEDCGKTFIGSSALVIHQRVHTGEKPYECEECGKVFSHSSNLIKHQRTH 398
            .|..|.|.||.||.|.|:.|||:|..:..|.:|.|:||||:||.|::|||.|..:.||..|.|.|
Zfish    91 KLDVHIRDHTREKAYTCKQCGKSFYNTRNLTVHMRIHTGERPYTCQQCGKSFHKTGNLTVHLRIH 155

Human   399 TGEKPYECDDCGKTFSQSCSLLEHHKIHTGEKPYQCNMCGKAFRRNSHLLRHQRIHGDKNVQNPE 463
            |||:||.|..|||:|..:.:|..|.:||||||||.|..|||::.:||:|..|.|.|
Zfish   156 TGERPYTCQQCGKSFQTTGNLTVHMRIHTGEKPYSCPQCGKSYSQNSNLEVHMRTH--------- 211

Human   464 HGESWESQGRTESQWENTEAPVSYKCNECERSFTRNRSLIEHQKIHTGEKPYQCDTCGKGFTRTS 528
                  :.|||            :.|.:|.:.|.:.::|..|.:||||||||.|..|||.|...|
Zfish   212 ------NGGRT------------FVCTQCGKRFVKKQNLDLHMRIHTGEKPYTCTECGKSFPYKS 258

Human   529 YLVQHQRSHVGKK 541
            .|..|...|.|:|
Zfish   259 TLKHHMIVHTGEK 271

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ZKSCAN4	NP_061983.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..22
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	34..55
		SCAN	49..160	CDD:128708
		KRAB	221..281	CDD:214630	8/59 (14%)
		zf-C2H2	320..342	CDD:306579	10/22 (45%)
		C2H2 Zn finger	322..342	CDD:275368	10/19 (53%)
		zf-H2C2_2	335..357	CDD:316026	12/21 (57%)
		C2H2 Zn finger	350..370	CDD:275368	8/19 (42%)
		COG5048	<374..544	CDD:227381	69/168 (41%)
		C2H2 Zn finger	378..398	CDD:275368	9/19 (47%)
		C2H2 Zn finger	406..426	CDD:275368	7/19 (37%)
		C2H2 Zn finger	434..454	CDD:275368	9/19 (47%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	455..480		3/24 (13%)
		C2H2 Zn finger	489..509	CDD:275368	5/19 (26%)
		C2H2 Zn finger	517..537	CDD:275368	8/19 (42%)
si:dkey-122c11.8	XP_017211097.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	212	1.000	Inparanoid score	I10838
NCBI	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.960