DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ets65A and Fli1

DIOPT Version :9

Sequence 1:	NP_001303373.1	Gene:	Ets65A / 38700	FlyBaseID:	FBgn0005658	Length:	728	Species:	Drosophila melanogaster
Sequence 2:	XP_038937318.1	Gene:	Fli1 / 315532	RGDID:	1309837	Length:	471	Species:	Rattus norvegicus

Alignment Length:	483	Identity:	183/483 - (37%)
Similarity:	237/483 - (49%)	Gaps:	82/483 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    53 LKQSVEKAKAALQDRSSFFGASSAFSDIYSSQRLTDS----------LDTLPVQSG--------- 98
            |..|:|.......|:|.|..|..|.:.:..:. :|.|          ::.||.|..
  Rat    21 LLHSMEALSVVSDDQSLFDSAYGAAAHLPKAD-MTASGSPDYGQPHKINPLPPQQEWINQPVRVN 84

  Fly    99 --------NGGG----NCLGLPHNPNVGVGVAGVLNYNAVSSSTAGVLSSSGNGVQRHRLDTLQP 151
                    ||..    :|.....|..||.|.|..:|||:......|....:....:|..:....|
  Rat    85 VKREYDHMNGSRESPVDCSVSKCNKLVGGGEANPMNYNSYMDEKNGPPPPNMTTNERRVIVPADP 149

  Fly   152 PSGCSP--------AVTQHGVI---TSSAGQVTSGTLDAVSAAPALPSLTASSS----SHVEHKV 201
            ......        |:.::|::   ||....:....|..:|....|.:.:..::    ||:.:
  Rat   150 TLWTQEHVRQWLEWAIKEYGLMEIDTSFFQNMDGKELCKMSKEDFLRATSLYNTEVLLSHLSY-- 212

  Fly   202 RADKSTLDCATTSSHAAAPSSSSSASDHQQGRISGSKSSNTSGTGGGASASGGGGSALYSSYKSS 266
             ..:|:|....|.||....|..:...|.....:.....||...:|...|...||
  Rat   213 -LRESSLLAYNTPSHTDQSSRLNVKEDPSYDSVRRGGWSNNMNSGINKSPPLGG----------- 265

  Fly   267 WGSHSSTQSQGYSSNALGIKHDPHSQLRQPDPYQMFGPTSSRLASSGSGQIQLWQFLLELLSDSN 331
                  .||.|.::          .|..||||||:.||||||||:.||||||||||||||||||.
  Rat   266 ------AQSMGKNT----------EQRPQPDPYQILGPTSSRLANPGSGQIQLWQFLLELLSDSA 314

  Fly   332 NASCITWEGTNGEFKLTDPDEVARRWGERKSKPNMNYDKLSRALRYYYDKNIMTKVHGKRYAYKF 396
            |||||||||||||||:|||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   315 NASCITWEGTNGEFKMTDPDEVARRWGERKSKPNMNYDKLSRALRYYYDKNIMTKVHGKRYAYKF 379

  Fly   397 DFQGLAAATQPAASDPT-YKYQSDL-FMTPYHHSAKLSSFMSPH-HGMTSSSASIFPSAASWGNW 458
            ||.|:|.|.||..::.: |||.||: :|..||...:..:|:.|| ..|..:|:|.|.:|:.:  |
  Rat   380 DFHGIAQALQPHPTETSMYKYPSDISYMPSYHAHQQKVNFVQPHPSSMPVTSSSFFGAASQY--W 442

  Fly   459 GSPATNLYQPHSMSHVTPSHVAPHLSSY 486
            .||...:|...|:.....:||..||.||
  Rat   443 TSPTAGIYPNPSVPRHPNTHVPSHLGSY 470

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ets65A	NP_001303373.1	ETS	316..401	CDD:197710	81/84 (96%)
Fli1	XP_038937318.1	SAM_PNT-FLI-1	133..223	CDD:188883	13/92 (14%)
Fli1	XP_038937318.1	ETS	299..382	CDD:197710	80/82 (98%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	168	1.000	Domainoid score	I3746
eggNOG	1	0.900	-	-		E1_KOG3806
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1113327at2759
OrthoFinder	1	1.000	-	-		FOG0003089
OrthoInspector	1	1.000	-	-		otm45611
orthoMCL	1	0.900	-	-		OOG6_105242
Panther	1	1.100	-	-	LDO	PTHR11849
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1794
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	9.820