DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ets65A and fli1

DIOPT Version :9

Sequence 1:	NP_001303373.1	Gene:	Ets65A / 38700	FlyBaseID:	FBgn0005658	Length:	728	Species:	Drosophila melanogaster
Sequence 2:	XP_021323256.1	Gene:	fli1 / 30619	ZFINID:	ZDB-GENE-980526-426	Length:	474	Species:	Danio rerio

Alignment Length:	524	Identity:	188/524 - (35%)
Similarity:	251/524 - (47%)	Gaps:	119/524 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 LALGQCSPEWTSY---RFHQSTFEQLKQSVEKAKAALQDRSSF---FGASSAF--SDIYSS---- 83
            :.:.|..|:.:||   |.|:. .||     |......:|:|.|   :.|::..  :|:.:|
Zfish     1 MTMFQTVPDTSSYVKVRHHRH-HEQ-----EALSVVSEDQSLFEPPYAAAAPLPKTDMTASGTQD 59

  Fly    84 QRLTDSLDTLPVQSG-----------------NGG---------GNCLGLPHNPNVGVGVAGVLN 122
            ...|..::.:|.|..                 ||.         |.|     |..||...|..:|
Zfish    60 YGQTHKINPIPPQQEWINQPVRVNVKREYDHINGSRESPVDCSVGKC-----NKMVGGTEASQMN 119

  Fly   123 YNA-----------VSSSTAGVLSSSGNGVQRHRLDTLQPPSGCSP---------AVTQHGV--I 165
            |..           ::::...|:..:|        :....||..||         |:.::|:  |
Zfish   120 YTGYMDEKCAPPPNMTTNERRVIVPAG--------EYCINPSLWSPDHVRQWLDWAIKEYGLQEI 176

  Fly   166 TSSAGQVTSGTLDAVSAAPALPSLTASSS-----SHVEHKVRADKSTLDCATTSSHAAAPSSSSS 225
            .::....|.|......:......||:..:     ||:.: :|...|::. ..|.|||......::
Zfish   177 DTAMFHSTDGKELCKMSKDDFLRLTSVYNTEVLLSHLNY-LRESSSSIS-YNTPSHADQSPRLAA 239

  Fly   226 ASDHQQGRISGSKSSNTSGTGGGASASGGGGSALYSSYKSSWGSHSSTQSQGYSSNALGIKHDPH 290
            ..|.....:..:..||...:|.|:                     .:..||..|.|       |.
Zfish   240 KDDASYDAVRRTGWSNNMHSGKGS---------------------PTVVSQSVSKN-------PD 276

  Fly   291 SQLRQPDPYQMFGPTSSRLASSGSGQIQLWQFLLELLSDSNNASCITWEGTNGEFKLTDPDEVAR 355
            ....||||||:.||||||||:.||||||||||||||||||.||.||||||||||||:||||||||
Zfish   277 QPRPQPDPYQILGPTSSRLANPGSGQIQLWQFLLELLSDSANAGCITWEGTNGEFKMTDPDEVAR 341

  Fly   356 RWGERKSKPNMNYDKLSRALRYYYDKNIMTKVHGKRYAYKFDFQGLAAATQPAASDPT-YKYQSD 419
            |||||||||||||||||||||||||||||||||||||||||||.|:|.|.||..::.| |||.|:
Zfish   342 RWGERKSKPNMNYDKLSRALRYYYDKNIMTKVHGKRYAYKFDFHGIAQALQPHPTESTMYKYPSE 406

  Fly   420 L-FMTPYHHSAKLSSFMSPH-HGMTSSSASIFPSAASWGNWGSPATNLYQPHSMSHVTPSHVAPH 482
            | ::..||...:..:|:||| ..|..:|::.|.....:  |.||...:|...|:.....|||..|
Zfish   407 LPYVPSYHAHQQKVNFVSPHPPSMPVTSSNFFGPTTPY--WSSPPGGIYPNPSVPRHANSHVPSH 469

  Fly   483 LSSY 486
            |.||
Zfish   470 LGSY 473

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ets65A	NP_001303373.1	ETS	316..401	CDD:197710	80/84 (95%)
fli1	XP_021323256.1	SAM_PNT-FLI-1	131..226	CDD:188883	17/104 (16%)
fli1	XP_021323256.1	ETS	302..385	CDD:197710	79/82 (96%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	166	1.000	Domainoid score	I3832
eggNOG	1	0.900	-	-		E1_KOG3806
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	259	1.000	Inparanoid score	I3116
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1113327at2759
OrthoFinder	1	1.000	-	-		FOG0003089
OrthoInspector	1	1.000	-	-		otm24546
orthoMCL	1	0.900	-	-		OOG6_105242
Panther	1	1.100	-	-	LDO	PTHR11849
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3711
SonicParanoid	1	1.000	-	-		X1794
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	11	10.900