DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ets65A and Fev

DIOPT Version :9

Sequence 1:	NP_001303373.1	Gene:	Ets65A / 38700	FlyBaseID:	FBgn0005658	Length:	728	Species:	Drosophila melanogaster
Sequence 2:	NP_694751.1	Gene:	Fev / 260298	MGIID:	2449712	Length:	237	Species:	Mus musculus

Alignment Length:	247	Identity:	118/247 - (47%)
Similarity:	139/247 - (56%)	Gaps:	57/247 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   296 PDPY----------QMFGPTSSRLASSGSGQIQLWQFLLELLSDSNNASCITWEGTNGEFKLTDP 350
            |||.          ..:||.|..: ..|||||||||||||||:|..||.||.|||.:||||||||
Mouse    17 PDPVGDGLFKEGKSPSWGPLSPAV-QKGSGQIQLWQFLLELLADRANAGCIAWEGGHGEFKLTDP 80

  Fly   351 DEVARRWGERKSKPNMNYDKLSRALRYYYDKNIMTKVHGKRYAYKFDFQGLAAATQP-------- 407
            ||||||||||||||||||||||||||||||||||:|||||||||:|||||||.|.||
Mouse    81 DEVARRWGERKSKPNMNYDKLSRALRYYYDKNIMSKVHGKRYAYRFDFQGLAQACQPPPAHAHAA 145

  Fly   408 --------AASD-PTYKYQSDLFMTPYHHSAKLSSFMSPHHGMTSSSASIFPSAASWGNWGSP-A 462
                    ||.| ..||..:.|...|:...:||:        :.::||.:.|:..|:  |..| |
Mouse   146 AAAAAAAAAAQDGALYKLPAGLAPLPFPGLSKLN--------LMAASAGVAPAGFSY--WPGPNA 200

  Fly   463 TNLYQPHSMSHVTPSHVAPHLSSYPHYAXPSSSGGAFXYESNAIASASGIGG 514
            |......:..:.||....|          |...|        |:|:||.:||
Mouse   201 TAAAAATAALYPTPGLQPP----------PGPFG--------AVAAASHLGG 234

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ets65A	NP_001303373.1	ETS	316..401	CDD:197710	75/84 (89%)
Fev	NP_694751.1	ETS	46..131	CDD:197710	75/84 (89%)
Fev	NP_694751.1	May mediate active transcriptional repression. /evidence=ECO:0000250	129..237		35/134 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3806
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S3194
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3711
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	5	4.750