DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ets65A and ELF4

DIOPT Version :10

Sequence 1:NP_001303373.1 Gene:Ets65A / 38700 FlyBaseID:FBgn0005658 Length:728 Species:Drosophila melanogaster
Sequence 2:NP_001412.1 Gene:ELF4 / 2000 HGNCID:3319 Length:663 Species:Homo sapiens


Alignment Length:591 Identity:142/591 - (24%)
Similarity:217/591 - (36%) Gaps:172/591 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly   147 DTLQPPSGCSPAVTQHGVITS-----SAGQVTSG----------TLDAVSAAPALPSLTASSSSH 196
            |.|...||.......:|:||.     :..|:..|          |...:|.|..|.::.:.|...
Human    44 DLLHLYSGLELDDVHNGIITDGTLCMTQDQILEGSFLLTDDNEATSHTMSTAEVLLNMESPSDIL 108

  Fly   197 VEHKVRA------DKSTLDCATTSSH---AAAPSSSSSASD--HQQGRISGSKSSNTSGTGGGAS 250
            .|.::.:      |.......|..::   |:.|.:.:.|.|  .|:|.....|:|...      |
Human   109 DEKQIFSTSEMLPDSDPAPAVTLPNYLFPASEPDALNRAGDTSDQEGHSLEEKASREE------S 167

  Fly   251 ASGGGGSALYSSYKSSWGSHSSTQSQGYSSNALGIKHDPHSQLRQPDPYQMFGPTSSRLASSGSG 315
            |...|.|.  ...:.:.|:.|::...           ||...:|             :.:..|.|
Human   168 AKKTGKSK--KRIRKTKGNRSTSPVT-----------DPSIPIR-------------KKSKDGKG 206

  Fly   316 Q-IQLWQFLLELLSDSNNASC---ITW-EGTNGEFKLTDPDEVARRWGERKSKPNMNYDKLSRAL 375
            . |.||:|||.||.|.|  :|   |.| :...|.|||.|...|::.||::|:||:|||:.:.|||
Human   207 STIYLWEFLLALLQDRN--TCPKYIKWTQREKGIFKLVDSKAVSKLWGKQKNKPDMNYETMGRAL 269

  Fly   376 RYYYDKNIMTKVHGKRYAYKF-------------DFQGLAAATQPAASDPTYKYQSDLFMTPYHH 427
            ||||.:.|:.||.|:|..|:|             |....|.|..|.||..:....|    |....
Human   270 RYYYQRGILAKVEGQRLVYQFKEMPKDLVVIEDEDESSEATAAPPQASTASVASAS----TTRRT 330

  Fly   428 SAKLSSFMSPHHGMTSSSASIFPSAASWGNWGSPATNLYQPHSMSHV--TPS---HVAPHLSSYP 487
            |:::||..:| .|..|||            |..|        .:.||  .||   .:.|.|..  
Human   331 SSRVSSRSAP-QGKGSSS------------WEKP--------KIQHVGLQPSASLELGPSLDE-- 372

  Fly   488 HYAXPSSSGGAFXYESNAIASASGIGGGTASTGVGIGGVGGAGGGGGSGVSTGVGSTSSSTTSSG 552
              ..|::|..........:.....:...:..:.:.: ||...|.|....:.| :..|        
Human   373 --EIPTTSTMLVSPAEGQVKLTKAVSASSVPSNIHL-GVAPVGSGSALTLQT-IPLT-------- 425

  Fly   553 AGGGGGGGGGTVMSGFGSNGNLNGSHVSSSGGSSSVSNNLNIA-----TATLTAT-PAHASAGFG 611
                      ||::        ||...|::..:..|..::..|     |.||.|: |.:||    
Human   426 ----------TVLT--------NGPPASTTAPTQLVLQSVPAASTFKDTFTLQASFPLNAS---- 468

  Fly   612 TIGGLSVAGMGVGVGVGVGVGGGNSTLNSLVVG-NRLMNSSLPTLLKXCHLEKFGLTMGAGPSPP 675
             .....||..|..:.:        |.|..|:.| ||..|.:.||:            .||||:.|
Human   469 -FQDSQVAAPGAPLIL--------SGLPQLLAGANRPTNPAPPTV------------TGAGPAGP 512

  Fly   676 AATPAG 681
            ::.|.|
Human   513 SSQPPG 518

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ets65ANP_001303373.1 ETS 316..401 CDD:197710 42/102 (41%)
ELF4NP_001412.1 Elf-1_N 2..104 CDD:463529 13/59 (22%)
RUNX1-binding. /evidence=ECO:0000269|PubMed:10207087 87..206 26/150 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 140..203 16/94 (17%)
ETS 208..290 CDD:197710 40/83 (48%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 302..353 18/75 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 493..518 11/36 (31%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 582..605
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 635..663
Blue background indicates that the domain is not in the aligned region.

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