DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ets65A and Erg

DIOPT Version :9

Sequence 1:	NP_001303373.1	Gene:	Ets65A / 38700	FlyBaseID:	FBgn0005658	Length:	728	Species:	Drosophila melanogaster
Sequence 2:	XP_038943856.1	Gene:	Erg / 170909	RGDID:	621108	Length:	486	Species:	Rattus norvegicus

Alignment Length:	550	Identity:	191/550 - (34%)
Similarity:	253/550 - (46%)	Gaps:	152/550 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 PPTLAQVKTEECLALGQCSPEWTSYRFHQSTFEQLKQSVEKAKAAL-QDRSSFFGASSAFSDIYS 82
            |...||:|.    ||...|.:       ||.||....:...||..: ...||.:|.:|..|....
  Rat     6 PDPEAQIKE----ALSVVSED-------QSLFECAYGTPHLAKTEMTASSSSDYGQTSKMSPRVP 59

  Fly    83 SQ--------RLTDSLDTLPVQSGNG------------GGNCLGLPHNPNVGVGVAGVLNYNAVS 127
            .|        |:|..::..|.|. ||            ||..:|.|  ..||:.....:.
  Rat    60 QQDWLSQPPARVTIKMECNPSQV-NGSRNSPDECSVTKGGKMVGSP--DTVGMSYGSYME----- 116

  Fly   128 SSTAGVLSSSGNGVQRHRLDTLQPPSGCSPAVTQHGVITSSAGQVTSGTLDAVSAAPALPSLTAS 192
                          ::|    :.||:           :|::..:|         ..||.|:|.
  Rat   117 --------------EKH----MPPPN-----------MTTNERRV---------IVPADPTLW-- 141

  Fly   193 SSSHV----EHKVRADKSTLD--------------CATTS----------------SH----AAA 219
            |:.||    |..|: :...||              |..|.                ||    ...
  Rat   142 STDHVRQWLEWAVK-EYGLLDVDVLLFQNIDGKELCKMTKDDFQRLTPSYNADILLSHLHYLRET 205

  Fly   220 PSSSSSASDHQQGRISGSKSSNTSGTGGGASASGGGGSALYSS----------------YKSSWG 268
            |....::.|..:...:..:..:...|||.|...  ..:::|..                .:|:|.
  Rat   206 PLPHLTSDDVDKALQNSPRLMHARNTGGAAFIF--PNTSVYPEATQRITTRPDLPYEPPRRSTWT 268

  Fly   269 SHSSTQSQGY----SSNALGIKHDPHSQLRQPDPYQMFGPTSSRLASSGSGQIQLWQFLLELLSD 329
            .||....|..    |.:.:....|...||   ||||:.||||||||:.|||||||||||||||||
  Rat   269 GHSHPTPQSKAAQPSPSTVPKTEDQRPQL---DPYQILGPTSSRLANPGSGQIQLWQFLLELLSD 330

  Fly   330 SNNASCITWEGTNGEFKLTDPDEVARRWGERKSKPNMNYDKLSRALRYYYDKNIMTKVHGKRYAY 394
            |:|::||||||||||||:|||||||||||||||||||||||||||||||||||||||||||||||
  Rat   331 SSNSNCITWEGTNGEFKMTDPDEVARRWGERKSKPNMNYDKLSRALRYYYDKNIMTKVHGKRYAY 395

  Fly   395 KFDFQGLAAATQPAASDPT-YKYQSDL-FMTPYHHSAKLSSFMSPH-HGMTSSSASIFPSAASWG 456
            ||||.|:|.|.||...:.: |||.||| :|..||...:..:|::|| ..:..:|:|.|.:...:
  Rat   396 KFDFHGIAQALQPHPPESSLYKYPSDLPYMGSYHTHPQKMNFVAPHPPALPVTSSSFFATPNPY- 459

  Fly   457 NWGSPATNLYQPHSMSHVTPSHVAPHLSSY 486
             |.||...:| |:  :.:..||:..||.:|
  Rat   460 -WNSPTGGIY-PN--TRLPASHMPSHLGTY 485

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ets65A	NP_001303373.1	ETS	316..401	CDD:197710	79/84 (94%)
Erg	XP_038943856.1	SAM_superfamily	122..205	CDD:417767	19/105 (18%)
Erg	XP_038943856.1	ETS	317..400	CDD:197710	78/82 (95%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	57	1.000	Domainoid score	I10634
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1113327at2759
OrthoFinder	1	1.000	-	-		FOG0003089
OrthoInspector	1	1.000	-	-		otm45611
orthoMCL	1	0.900	-	-		OOG6_105242
Panther	1	1.100	-	-	O	PTHR11849
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1794
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.920