Protein Alignment RHOA and Mtl

DIOPT Version :10

• Sequence 1: NP_001655.1
• Gene: RHOA / 387
• HGNCID: 667
• Length: 193
• Species: Homo sapiens
• Sequence 2: NP_524533.1
• Gene: Mtl / 43319
• FlyBaseID: FBgn0039532
• Length: 195
• Species: Drosophila melanogaster
• Alignment Length: 191
• Identity: 109/191 - (57%)
• Similarity: 135/191 - (70%)
• Gaps: 7/191 - (3%)

Human     7 KLVIVGDGACGKTCLLIVFSKDQFPEVYVPTVFENYVADIEVDGKQVELALWDTAGQEDYDRLRP 71
            |.|:||||..||||:||.::.|.||..||||||:||.|.::||..||.|.|||||||||||||||
  Fly     8 KCVVVGDGTVGKTCMLISYTTDCFPGEYVPTVFDNYSAPMQVDTIQVSLGLWDTAGQEDYDRLRP 72

Human    72 LSYPDTDVILMCFSIDSPDSLENIPEKWTPEVKHFCPNVPIILVGNKKDLRNDEHTRRELAKMKQ 136
            ||||.|||.|:|:|:.||.|.||:..||.||:||.||:.||||||.|.|||.|..|...||:...
  Fly    73 LSYPQTDVFLICYSVASPSSFENVTSKWYPEIKHHCPDAPIILVGTKIDLREDRETLSGLAEQGL 137

Human   137 EPVKPEEGRDMANRIGAFGYMECSAKTKDGVREVFEMATRAALQ----ARRGKKKSGCLVL 193
            .|:|.|:|:.:||:|.|..||||||.|:.|::.|||.|.||.|:    .||.:|   ||::
  Fly   138 TPLKREQGQKLANKIRAVKYMECSALTQRGLKPVFEEAVRAVLRPEPLKRRQRK---CLIM 195

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RHOA	NP_001655.1	RhoA_like	5..179	CDD:206662	103/171 (60%)
		Effector region. /evidence=ECO:0000255	34..42		6/7 (86%)
		Switch II region, involved in RAP1GDS1 isoform 2 binding. /evidence=ECO:0000269|PubMed:30190425, ECO:0007744|PDB:5ZHX	61..78		15/16 (94%)
Mtl	NP_524533.1	RHO	9..182	CDD:197554	103/172 (60%)