Protein Alignment RHOA and RhoL

DIOPT Version :10

• Sequence 1: NP_001655.1
• Gene: RHOA / 387
• HGNCID: 667
• Length: 193
• Species: Homo sapiens
• Sequence 2: NP_001247003.1
• Gene: RhoL / 41136
• FlyBaseID: FBgn0014380
• Length: 214
• Species: Drosophila melanogaster
• Alignment Length: 189
• Identity: 91/189 - (48%)
• Similarity: 123/189 - (65%)
• Gaps: 13/189 - (6%)

Human     7 KLVIVGDGACGKTCLLIVFSKDQFPEVYVPTVFENYVADIEVDGKQVELALWDTAGQEDYDRLRP 71
            |:.|||||..||||:||.:::::|||.|:||||:|:..:|.||.:...|.||||||||||:||||
  Fly    37 KITIVGDGMVGKTCMLITYTRNEFPEEYIPTVFDNHACNIAVDDRDYNLTLWDTAGQEDYERLRP 101

Human    72 LSYPDTDVILMCFSIDSPDSLENIPEKWTPEVKHFCPNVPIILVGNKKDLR--NDEHTRRELAKM 134
            ||||.|:..|:|:||.|..|.||:..||.||::||..:||::|||.|.|||  |.|
  Fly   102 LSYPSTNCFLLCYSISSRTSFENVKSKWWPEIRHFSAHVPVVLVGTKLDLRIPNSE--------- 157

Human   135 KQEPVKPEEGRDMANRIGAFGYMECSAKTKDGVREVFEMATRAALQARRGKKKSGCLVL 193
              :.|..:||:.|...|.||..:|||||.|..:::|||.|.||..:..:...|..|.:|
  Fly   158 --KFVTTQEGKKMRKEIHAFNLVECSAKKKQNLQQVFEEAVRAVERKPKTTSKQSCKIL 214

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RHOA	NP_001655.1	RhoA_like	5..179	CDD:206662	88/173 (51%)
		Effector region. /evidence=ECO:0000255	34..42		5/7 (71%)
		Switch II region, involved in RAP1GDS1 isoform 2 binding. /evidence=ECO:0000269|PubMed:30190425, ECO:0007744|PDB:5ZHX	61..78		14/16 (88%)
RhoL	NP_001247003.1	Rho	36..198	CDD:206641	86/171 (50%)