Protein Alignment RHOA and Rac2

DIOPT Version :10

• Sequence 1: NP_001655.1
• Gene: RHOA / 387
• HGNCID: 667
• Length: 193
• Species: Homo sapiens
• Sequence 2: NP_648121.1
• Gene: Rac2 / 38831
• FlyBaseID: FBgn0014011
• Length: 192
• Species: Drosophila melanogaster
• Alignment Length: 194
• Identity: 107/194 - (55%)
• Similarity: 135/194 - (69%)
• Gaps: 3/194 - (1%)

Human     1 MAAIRKKLVIVGDGACGKTCLLIVFSKDQFPEVYVPTVFENYVADIEVDGKQVELALWDTAGQED 65
            |.||  |.|:|||||.|||||||.::.:.||..|:||||:||.|::.||.|.:.|.|||||||||
  Fly     1 MQAI--KCVVVGDGAVGKTCLLISYTTNAFPGEYIPTVFDNYSANVMVDAKPINLGLWDTAGQED 63

Human    66 YDRLRPLSYPDTDVILMCFSIDSPDSLENIPEKWTPEVKHFCPNVPIILVGNKKDLRNDEHTRRE 130
            ||||||||||.|||.|:|||:.:|.|.||:..||.|||:|.||:|||||||.|.|||:|:.|..:
  Fly    64 YDRLRPLSYPQTDVFLICFSLVNPASFENVRAKWFPEVRHHCPSVPIILVGTKLDLRDDKQTIEK 128

Human   131 LAKMKQEPVKPEEGRDMANRIGAFGYMECSAKTKDGVREVFEMATRAAL-QARRGKKKSGCLVL 193
            |...|..|:...:|..||..|.|..|:||||.|:.|::.||:.|.|:.| ...||.|:..|.:|
  Fly   129 LKDKKLTPITYPQGLAMAKEIAAVKYLECSALTQKGLKTVFDEAIRSVLCPVVRGPKRHKCALL 192

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RHOA	NP_001655.1	RhoA_like	5..179	CDD:206662	98/173 (57%)
		Effector region. /evidence=ECO:0000255	34..42		5/7 (71%)
		Switch II region, involved in RAP1GDS1 isoform 2 binding. /evidence=ECO:0000269|PubMed:30190425, ECO:0007744|PDB:5ZHX	61..78		15/16 (94%)
Rac2	NP_648121.1	Rac1_like	3..176	CDD:206663	100/174 (57%)