Protein Alignment RHOA and Rho1

DIOPT Version :10

• Sequence 1: NP_001655.1
• Gene: RHOA / 387
• HGNCID: 667
• Length: 193
• Species: Homo sapiens
• Sequence 2: NP_477098.1
• Gene: Rho1 / 36775
• FlyBaseID: FBgn0014020
• Length: 192
• Species: Drosophila melanogaster
• Alignment Length: 193
• Identity: 167/193 - (86%)
• Similarity: 181/193 - (93%)
• Gaps: 1/193 - (0%)

Human     1 MAAIRKKLVIVGDGACGKTCLLIVFSKDQFPEVYVPTVFENYVADIEVDGKQVELALWDTAGQED 65
            |..||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Fly     1 MTTIRKKLVIVGDGACGKTCLLIVFSKDQFPEVYVPTVFENYVADIEVDGKQVELALWDTAGQED 65

Human    66 YDRLRPLSYPDTDVILMCFSIDSPDSLENIPEKWTPEVKHFCPNVPIILVGNKKDLRNDEHTRRE 130
            ||||||||||||||||||||:||||||||||||||||||||||||||||||||||||||.:|.|:
  Fly    66 YDRLRPLSYPDTDVILMCFSVDSPDSLENIPEKWTPEVKHFCPNVPIILVGNKKDLRNDPNTIRD 130

Human   131 LAKMKQEPVKPEEGRDMANRIGAFGYMECSAKTKDGVREVFEMATRAALQARRGKKKSGCLVL 193
            |||||||||||:|||.||.:|.||.|:|||||:|:|||:|||.|||||||.:: :||:.||:|
  Fly   131 LAKMKQEPVKPQEGRAMAEKINAFAYLECSAKSKEGVRDVFETATRAALQVKK-RKKTRCLLL 192

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RHOA	NP_001655.1	RhoA_like	5..179	CDD:206662	157/173 (91%)
		Effector region. /evidence=ECO:0000255	34..42		7/7 (100%)
		Switch II region, involved in RAP1GDS1 isoform 2 binding. /evidence=ECO:0000269|PubMed:30190425, ECO:0007744|PDB:5ZHX	61..78		16/16 (100%)
Rho1	NP_477098.1	RhoA_like	5..179	CDD:206662	157/173 (91%)