Protein Alignment RHOA and RhoU

DIOPT Version :10

• Sequence 1: NP_001655.1
• Gene: RHOA / 387
• HGNCID: 667
• Length: 193
• Species: Homo sapiens
• Sequence 2: NP_001036266.1
• Gene: RhoU / 31945
• FlyBaseID: FBgn0083940
• Length: 582
• Species: Drosophila melanogaster
• Alignment Length: 168
• Identity: 67/168 - (39%)
• Similarity: 100/168 - (59%)
• Gaps: 3/168 - (1%)

Human     7 KLVIVGDGACGKTCLLIVFSKDQFPEVYVPTVFENYVADIEVDGKQVELALWDTAGQEDYDRLRP 71
            |.|:|||||.|||.|::.:.:::|...::||..:.|.||:.|:...|.|.:.|||||:..|.||.
  Fly   394 KCVLVGDGAVGKTNLILSYLENRFNPEHIPTASDIYNADVNVNESPVHLTICDTAGQDTLDPLRE 458

Human    72 LSYPDTDVILMCFSIDSPDSLENIPEKWTPEVKHFCPNVPIILVGNKKDLRNDEHTRRELAKMKQ 136
            |.|||:||.|:|||:..|::...|..||.|  |.......:||||.:.|||...:...:|....:
  Fly   459 LCYPDSDVFLLCFSVVKPETFRAIKTKWAP--KFAKTKAALILVGTQADLRTSPNVLNKLQTNGE 521

Human   137 EPVKPEEGRDMANRIGAFGYMECSAKTKDGVREVFEMA 174
            |.:...:..|:|..||| .|:|.|:.|:|.|::||:.|
  Fly   522 EAISYADAWDLATTIGA-KYIETSSATQDKVKDVFDTA 558

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RHOA	NP_001655.1	RhoA_like	5..179	CDD:206662	67/168 (40%)
		Effector region. /evidence=ECO:0000255	34..42		2/7 (29%)
		Switch II region, involved in RAP1GDS1 isoform 2 binding. /evidence=ECO:0000269|PubMed:30190425, ECO:0007744|PDB:5ZHX	61..78		10/16 (63%)
RhoU	NP_001036266.1	Wrch_1	393..562	CDD:133330	67/168 (40%)