DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment loj and TMED5

DIOPT Version :9

Sequence 1:	NP_648027.3	Gene:	loj / 38698	FlyBaseID:	FBgn0061492	Length:	237	Species:	Drosophila melanogaster
Sequence 2:	NP_057124.3	Gene:	TMED5 / 50999	HGNCID:	24251	Length:	229	Species:	Homo sapiens

Alignment Length:	235	Identity:	49/235 - (20%)
Similarity:	110/235 - (46%)	Gaps:	15/235 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 DQINLVLPIALICCCLLIDVTSAQEAQQPWYENLPAVAMDYKVHIDAGKEDCYHQYVKAGATFYV 72
            |:|.|..|:.|:.....:.:..|...       .|::..|:...:.||:::|::|.:...|:..:
Human     3 DKIWLPFPVLLLAALPPVLLPGAAGF-------TPSLDSDFTFTLPAGQKECFYQPMPLKASLEI 60

  Fly    73 SFSVVRGGDGMAGFAVRNPAGEVVKPYQWQATADYTDQVSPGGYYSVCIDNQFSRFAGKLV---- 133
            .:.|:.|......|.:.:|.|:.:...|.::...:|.:...|. |..|.||.||..:.|::
Human    61 EYQVLDGAGLDIDFHLASPEGKTLVFEQRKSDGVHTVETEVGD-YMFCFDNTFSTISEKVIFFEL 124

  Fly   134 ---NIYITVVKYDAWDKYAKEIEQLQLNMQNFTATVGTVERNINDMMGYQAHSRHRESRDYALLL 195
               |:.....:.:.|.||....:.|.:.:::...::.:::..::.....|...|..|:||..:..
Human   125 ILDNMGEQAQEQEDWKKYITGTDILDMKLEDILESINSIKSRLSKSGHIQTLLRAFEARDRNIQE 189

  Fly   196 DNNAYIQTFSISQIVVILITCSVQVFFVRKLFEVKSSSKS 235
            .|...:..:|:..:||:::..::||:.::.|||.|..|::
Human   190 SNFDRVNFWSMVNLVVMVVVSAIQVYMLKSLFEDKRKSRT 229

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
loj	NP_648027.3	EMP24_GP25L	47..228	CDD:279450	38/187 (20%)
TMED5	NP_057124.3	EMP24_GP25L	35..222	CDD:279450	38/187 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1693
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810