DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment loj and TMED6

DIOPT Version :9

Sequence 1:	NP_648027.3	Gene:	loj / 38698	FlyBaseID:	FBgn0061492	Length:	237	Species:	Drosophila melanogaster
Sequence 2:	NP_653277.2	Gene:	TMED6 / 146456	HGNCID:	28331	Length:	240	Species:	Homo sapiens

Alignment Length:	227	Identity:	60/227 - (26%)
Similarity:	108/227 - (47%)	Gaps:	23/227 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 VTSAQ---------EAQQPWYENLPAVAMDYKVHIDAGKEDCYHQYVKAGATFYVSFSVVR---- 78
            ||||:         ...||.:..  |...|:.:.|..|..:|:.|:......||.|:.|.|
Human    16 VTSARSQKTEPLSGSGDQPLFRG--ADRYDFAIMIPPGGTECFWQFAHQTGYFYFSYEVQRTVGM 78

  Fly    79 GGDGMAGFAVRNPAGEVVKPYQW-QATADYTDQVSPGGYYSVCIDNQFSRFAGKLVNIYITV-VK 141
            ..|........||.|.::...|. :...:::.|.:  |:|.:|:.||.:.|..  |.:|:.. |.
Human    79 SHDRHVAATAHNPQGFLIDTSQGVRGQINFSTQET--GFYQLCLSNQHNHFGS--VQVYLNFGVF 139

  Fly   142 YDAWDKYAKEIEQLQLNMQNFTATVGT--VERNINDMMGYQAHSRHRESRDYALLLDNNAYIQTF 204
            |:..:...|:.|:.|||........||  |:.||..|..|...:|.|:..|:.|:..|..|:..:
Human   140 YEGPETDHKQKERKQLNDTLDAIEDGTQKVQNNIFHMWRYYNFARMRKMADFFLIQSNYNYVNWW 204

  Fly   205 SISQIVVILITCSVQVFFVRKLFEVKSSSKSR 236
            |.:|.:||:::..:|::|:::||.|.:::.::
Human   205 STAQSLVIILSGILQLYFLKRLFNVPTTTDTK 236

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
loj	NP_648027.3	EMP24_GP25L	47..228	CDD:279450	51/188 (27%)
TMED6	NP_653277.2	EMP24_GP25L	43..228	CDD:279450	51/188 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165156473
Domainoid	1	1.000	69	1.000	Domainoid score	I9693
eggNOG	1	0.900	-	-		E1_KOG1693
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	74	1.000	Inparanoid score	I5276
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45744
OrthoDB	1	1.010	-	-		D1262544at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		oto90385
orthoMCL	1	0.900	-	-		OOG6_109201
Panther	1	1.100	-	-	LDO	PTHR22811
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R7267
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	12.800