DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ssp6 and DLG5

DIOPT Version :9

Sequence 1:	NP_001286952.1	Gene:	ssp6 / 38694	FlyBaseID:	FBgn0035676	Length:	866	Species:	Drosophila melanogaster
Sequence 2:	NP_004738.3	Gene:	DLG5 / 9231	HGNCID:	2904	Length:	1919	Species:	Homo sapiens

Alignment Length:	893	Identity:	171/893 - (19%)
Similarity:	271/893 - (30%)	Gaps:	296/893 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   132 IIVEKKNNSYGFTLQSYGIHYKRDEE----LEMITYVDYVEYGGPAYRAG-MREGDVILSINGKD 191
            ::|.::.:..|..:....|:....::    ||...|...|..|.||.:.| :..||.|::|||..
Human   704 MVVRRRKSLGGKVVTPLHINLSGQKDSGISLENGVYAAAVLPGSPAAKEGSLAVGDRIVAINGIA 768

  Fly   192 MEKADHKTIVEFIKQCDTRMRMVVLFEDCVRKVDLHMRYIQLQSMLQQKMNELERVHLRERELLE 256
            :   |:|:    :.:|::.:|      .|...:.|.:..:..||......|..|.:...::.|
Human   769 L---DNKS----LNECESLLR------SCQDSLTLSLLKVFPQSSSWSGQNIFENIKDSDKML-- 818

  Fly   257 GKWKTH--SLPARKKANA----NTSPSD-------GEGVSPTEVAGEAGFYR------------- 295
             .::.|  .:.|..|.|.    |::.:|       .:...|....|.:.|..
Human   819 -SFRAHGPEVQAHNKRNLIQHNNSTQTDIFYTDRLEDRKEPGPPGGSSSFLHKPFPGGPLQVCPQ 882

  Fly   296 --PALSTEDVPNIAARQHGVGGPGIIPPPAQFMLTYHYLDPTYRYVLRPTH------GSSEEFVD 352
              |:.|...:.:..:...|..|.|::             |...|..|.|..      |..|..:|
Human   883 ACPSASERSLSSFRSDASGDRGFGLV-------------DVRGRRPLLPFETEVGPCGVGEASLD 934

  Fly   353 GLGLQRSSSD-------------------HQPPAQRYVLQQTESV-DANSMTQPTTTAPTQYHST 397
            ....:.|:|.                   ::.|.||      :|: |.|:..:|.|.....|...
Human   935 KADSEGSNSGGTWPKAMLSSTAVPEKLSVYKKPKQR------KSIFDPNTFKRPQTPPKIDYLLP 993

  Fly   398 TGGSVKPPAPPPRTCEKHKPPAKPPKPEKEKSSGKHCH------------VGHSCNPCLGHFRWK 450
            ..|....|.|     .|...|..||||.:...|.|..|            ||.|.:
Human   994 GPGPAHSPQP-----SKRAGPLTPPKPPRRSDSIKFQHRLETSSESEATLVGSSPS--------- 1044

  Fly   451 SAEKSAVPAPDNVSLDAYDLASPCCDTHCVPSRRRHRQHKEHTHKHKHRDRERVESKEQRVRPKS 515
            ::..||:| ||      .|...|   .|..|.|:                        .|||..|
Human  1045 TSPPSALP-PD------VDPGEP---MHASPPRK------------------------ARVRIAS 1075

  Fly   516 TSHASPNANGGAGSGHHHHHHHHHHSHEQQQQQQQQQQQQQQQQQQQQQQQPIQTVPHHHH---- 576
            :.:  |..:|.:             ||...::...:....|:..:..|:::..::.|....
Human  1076 SYY--PEGDGDS-------------SHLPAKKSCDEDLTSQKVDELGQKRRRPKSAPSFRPKLAP 1125

  Fly   577 --YPHQMHNPCQVQSQSGSTRSRYFDLASGLASHCSLHS---CTSSEFATGDT-ASYTTSISTDT 635
              .|.|.....:....||.......:.|.....|.|.||   ...|..:.|.. .|.|.|.:..:
Human  1126 VVIPAQFLEEQKCVPASGELSPELQEWAPYSPGHSSRHSNPPLYPSRPSVGTVPRSLTPSTTVSS 1190

  Fly   636 LFWDPTSETAQSRQHSTKSRQSYEQQPQQQQPTHQGHHHHHHHQG------------DYH----- 683
            :..:|.......|.....|      .|..:....||.|....|||            ||.
Human  1191 ILRNPIYTVRSHRVGPCSS------PPAARDAGPQGLHPSVQHQGRLSLDLSHRTCSDYSEMRAT 1249

  Fly   684 ----------------------QRYHVTTTQMQPQQIYPNTIAYV---------QKPKSWDNLAN 717
                                  :|..:.:|...|:.:..:....|         |.|.:.|.|::
Human  1250 HGSNSLPSSARLGSSSNLQFKAERIKIPSTPRYPRSVVGSERGSVSHSECSTPPQSPLNIDTLSS 1314

  Fly   718 KAGFNVGYGYLDTVAVKPAI-------KMQIAQQRH---------------SMPRRNPYGRYSTY 760
            .:........|..:||.||.       :..:.:.||               |..:...|....|.
Human  1315 CSQSQTSASTLPRIAVNPASLGERRKDRPYVEEPRHVKVQKGSEPLGISIVSGEKGGIYVSKVTV 1379

  Fly   761 GDVEN-----YAPPPTEFVGELTTTTTTTITAKSTEELLA------ACDCLTPQQQAAIKAAQYQ 814
            |.:.:     |.....||.|         |..:|..|..|      .||.:|       ..|||.
Human  1380 GSIAHQAGLEYGDQLLEFNG---------INLRSATEQQARLIIGQQCDTIT-------ILAQYN 1428

  Fly   815 LSQNQKLSHQNSCQLGYYSHLPRPTTDVGTSTTSQQVHGAGDVQTTSE 862
            ...:|..||..|.     |||    ...||.:|.|   |:|  .||.|
Human  1429 PHVHQLSSHSRSS-----SHL----DPAGTHSTLQ---GSG--TTTPE 1462

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ssp6	NP_001286952.1	PDZ_signaling	130..216	CDD:238492	21/88 (24%)
DLG5	NP_004738.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	98..142
		Takusan	130..212	CDD:282652
		TPR_MLP1_2	231..353	CDD:285204
		COG1340	295..587	CDD:224259
		FliJ	310..449	CDD:304890
		BAR	417..601	CDD:299863
		PDZ_signaling	620..707	CDD:238492	0/2 (0%)
		DegQ	<702..771	CDD:223343	17/69 (25%)
		PDZ_signaling	722..790	CDD:238492	20/80 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	927..1122		50/263 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1150..1187		10/36 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1201..1230		8/34 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1245..1264		0/18 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1271..1306		5/34 (15%)
		PDZ	1347..1429	CDD:214570	20/97 (21%)
		dbPDZ_assoc	1427..1499	CDD:293216	17/50 (34%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1434..1493		15/43 (35%)
		PDZ	1499..1582	CDD:214570
		SH3_DLG5	1597..1659	CDD:212794
		GuKc	1732..1908	CDD:214504
		Guanylate_kin	1740..1907	CDD:279019
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900