DRSC/TRiP Functional Genomics Resources

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Protein Alignment ssp6 and MPDZ

DIOPT Version :9

Sequence 1:NP_001286952.1 Gene:ssp6 / 38694 FlyBaseID:FBgn0035676 Length:866 Species:Drosophila melanogaster
Sequence 2:NP_001362342.1 Gene:MPDZ / 8777 HGNCID:7208 Length:2103 Species:Homo sapiens


Alignment Length:654 Identity:125/654 - (19%)
Similarity:217/654 - (33%) Gaps:200/654 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly    67 QSHQQASHYVNGTGSLGRLKFHKS----LDASDEEIEYAQLSRSTHILGRHKSERYLASNPDEDR 127
            :::::...:::.|.:...|...:.    |.|..||||.||...:..:.   |.:|.:..|.:   
Human   492 ENYEKDEDFLSSTRNTNILPTEEEGYPLLSAEIEEIEDAQKQEAALLT---KWQRIMGINYE--- 550

  Fly   128 RRRTIIVE-----KKNNSYGFTLQ-SYGIHYKRDEELEMITYVDYVEYGGPAYRAG-MREGDVIL 185
                |:|.     .:|:..|.:|: :.|.|:.|....|           ||...:| :..||.:|
Human   551 ----IVVAHVSKFSENSGLGISLEATVGHHFIRSVLPE-----------GPVGHSGKLFSGDELL 600

  Fly   186 SINGKDMEKADHKTIVEFIKQCDTRMRMVVLFEDCVRKVDLHMRYIQLQSMLQQKMNELERVHLR 250
            .:||..:...:|:.:|..:|:....:.||     |.|:           ::.....:||:.:.|.
Human   601 EVNGITLLGENHQDVVNILKELPIEVTMV-----CCRR-----------TVPPTTQSELDSLDLC 649

  Fly   251 ERELLEGKWKTHSLPARKKANANTSPSDGEGVSPTEVAGEAGFYRPALSTEDV-PNIAARQHGV- 313
            :.||.|   |.|       .:........|...|.....:||     .|||:| ..:|..:.|: 
Human   650 DIELTE---KPH-------VDLGEFIGSSETEDPVLAMTDAG-----QSTEEVQAPLAMWEAGIQ 699

  Fly   314 ------GGPGIIPPPAQFMLTYH-YLDPTYRYVL--------------RPTHGSSEEFVDGLGLQ 357
                  |..|:    ...:|.|. .:||....::              |...|....||:.:.|:
Human   700 HIELEKGSKGL----GFSILDYQDPIDPASTVIIIRSLVPGGIAEKDGRLLPGDRLMFVNDVNLE 760

  Fly   358 RSSSDHQPPAQRYVLQQTESVDANSMTQPTTTAPTQ-YHSTTGGSVKPPAPPPRTCEK----HKP 417
            .||.:....|.:.....|..:   .:.:|...:|.: |.|....|.   ..||.:||:    .||
Human   761 NSSLEEAVEALKGAPSGTVRI---GVAKPLPLSPEEGYVSAKEDSF---LYPPHSCEEAGLADKP 819

  Fly   418 PAK---------------------PPKPEKEKSSGKHCHV----GHSCNPCLGHFRWKSAEKSAV 457
            ..:                     |..||.:........:    |.||...|.:       .|::
Human   820 LFRADLALVGTNDADLVDESTFESPYSPENDSIYSTQASILSLHGSSCGDGLNY-------GSSL 877

  Fly   458 PA--PDNVSLDAYDLASPCCDTHCVPSRRRHRQHKE-HTHKHKHRDRERVESKEQRVRPKS---- 515
            |:  |.:|           .:..|.|....|...:| :|.....|..|...|.:..:.|.|    
Human   878 PSSPPKDV-----------IENSCDPVLDLHMSLEELYTQNLLQRQDENTPSVDISMGPASGFTI 931

  Fly   516 TSHASPNANGGAGSGHHHHHHHHHHSHEQQQQQQQQQQQQQQQQQQQQQQQPIQTVPHHHHYPHQ 580
            ..:...||                                 .:||.:.:...:.|   ..|.|.:
Human   932 NDYTPANA---------------------------------IEQQYECENTIVWT---ESHLPSE 960

  Fly   581 MHNPCQVQS---QSGSTRSRYFDLASGLA--SHCSLHSCTSSE-------FATGDTA-SYTTSIS 632
            :.:..::.|   .|....|.|....|.||  :.|.:....|.|       .|.|::: ..|.|.:
Human   961 VISSAELPSVLPDSAGKGSEYLLEQSSLACNAECVMLQNVSKESFERTINIAKGNSSLGMTVSAN 1025

  Fly   633 TDTL 636
            .|.|
Human  1026 KDGL 1029

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ssp6NP_001286952.1 PDZ_signaling 130..216 CDD:238492 22/92 (24%)
MPDZNP_001362342.1 PDZ_signaling 2019..2102 CDD:238492
L27_2 6..63 CDD:312549
PDZ_signaling 139..221 CDD:238492
PDZ_signaling 257..334 CDD:238492
PDZ 374..463 CDD:214570
PDZ_signaling 560..629 CDD:238492 18/79 (23%)
PDZ_signaling 698..784 CDD:238492 15/92 (16%)
PDZ_signaling 1006..1076 CDD:238492 6/24 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1121..1140
PDZ_signaling 1149..1240 CDD:238492
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1278..1324
PDZ 1347..1433 CDD:214570
PDZ_signaling 1514..1593 CDD:238492
MPDZ_u10 1595..1659 CDD:374710
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1600..1645
PDZ 1660..1744 CDD:214570
PDZ_signaling 1758..1836 CDD:238492
PDZ_signaling 1893..1978 CDD:238492
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3528
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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