Protein Alignment ssp6 and PDZD7

DIOPT Version :9

• Sequence 1: NP_001286952.1
• Gene: ssp6 / 38694
• FlyBaseID: FBgn0035676
• Length: 866
• Species: Drosophila melanogaster
• Sequence 2: NP_001182192.1
• Gene: PDZD7 / 79955
• HGNCID: 26257
• Length: 1033
• Species: Homo sapiens
• Alignment Length: 739
• Identity: 131/739 - (17%)
• Similarity: 201/739 - (27%)
• Gaps: 333/739 - (45%)

  Fly    34 ATSVGSLIAAACQQEQPHPHQHYSQSQQQHLYHQSHQQASHYVNGTGSLGRLKFHKSLDASDEEI 98
            :|::||.:..            .:.|.:.|:          .|...|.:..:||.|      |:.
Human   143 STTMGSAVKV------------LTSSSRLHM----------MVRRMGRVPGIKFSK------EKT 179

  Fly    99 EYAQLSRSTHILGRHKSERYLASNP----DEDRRRRTIIVEKKNNSYGFTLQSYGIHYKRDEELE 159
            .:..      ::.|........|.|    .||..||  ||.....|..|.|   |.:.:..:|..
Human   180 TWVD------VVNRRLVVEKCGSTPSDTSSEDGVRR--IVHLYTTSDDFCL---GFNIRGGKEFG 233

  Fly   160 MITYVDYVEYGGPAYRAGMREGDVILSINGKDMEKADHKTIVEFIK------------------- 205
            :..||..|::||.|...|::.||.:|:.||...:...|...||.:|
Human   234 LGIYVSKVDHGGLAEENGIKVGDQVLAANGVRFDDISHSQAVEVLKGQTHIMLTIKETGRYPAYK 298

  Fly   206 ----------------------------------------------------------------- 205
                                                                             
Human   299 EMVSEYCWLDRLSNGVLQQLSPASESSSSVSSCASSAPYSSGSLPSDRMDICLGQEEPGSRGPGW 363

  Fly   206 -QCDTRMR-----------------MVVLFEDCVRKVDLH------------------------- 227
             :.||.|:                 .|:|.:..:|....|
Human   364 GRADTAMQTEPDAGGRVETWCSVRPTVILRDTAIRSDGPHPGRRLDSALSESPKTALLLALSRPR 428

  Fly   228 ------MRYIQLQSMLQQKMNEL-----ERVHL-RERELLE-----GKWKTHSLPARKKA----- 270
                  ..|:.|....||:..|.     |:..| |.:.|:.     |:....:...|::|
Human   429 PPITRSQSYLTLWEEKQQRKKEKSGSPGEKGALQRSKTLMNLFFKGGRQGRLARDGRREAWTLDS 493

  Fly   271 --NANTSP----SDGEGVSPTEV--------AGEAGFYRPALS------TEDVPNIAAR-QHGVG 314
              .|.|.|    ....||.|.:.        ..|.|  |..||      :..:||:..: |....
Human   494 GSLAKTYPRLDIEKAGGVGPVQKFVTWRLRRDQERG--RALLSARSGSPSSQLPNVDEQVQAWES 556

  Fly   315 GPGIIPPPAQFMLTYHYLDPTYRYVLRPTH-GSSEEFVDGL--GLQRSSSDHQPPAQRYVLQQTE 376
            ...:|...||.:||...:....|:..|..| |..|:.|..|  .|.|       |.:..:||...
Human   557 RRPLIQDLAQRLLTDDEVLAVTRHCSRYVHEGGIEDLVRPLLAILDR-------PEKLLLLQDIR 614

  Fly   377 SVDANSMTQPTTTAPTQ---------------YHSTTGGSVKPPA--------PPPRTCEKHKPP 418
            ||          .|||.               :.:....:|:|||        ||.|......|.
Human   615 SV----------VAPTDLGRFDSMVMLVELEAFEALKSRAVRPPALRPARQDTPPKRHLITPVPD 669

  Fly   419 AK------PPK--PEKE-----------------KSSGKHCHVGHSCNPCLGHFRWKSAEKSAVP 458
            ::      |..  ||:|                 .|:.:|.|.|                   :|
Human   670 SRGGFYLLPVNGFPEEEDNGELRERLGALKVSPSASAPRHPHKG-------------------IP 715

  Fly   459 APDNVSLDAYD-------------------------LASPCCDTHCVPSRRRHRQHKEHTHKHKH 498
            ...:|.:||:.                         |..|....|...|:.|.|.      :.:.
Human   716 PLQDVPVDAFTPLRIACTPPPQLPPVAPRPLRPNWLLTEPLSREHPPQSQIRGRA------QSRS 774

  Fly   499 RDRERVESKEQRVRPKSTSHASPN 522
            |.|.|..|:..|.:.||....||:
Human   775 RSRSRSRSRSSRGQGKSPGRRSPS 798

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ssp6	NP_001286952.1	PDZ_signaling	130..216	CDD:238492	28/187 (15%)
PDZD7	NP_001182192.1	PDZ_signaling	84..164	CDD:238492	5/42 (12%)
		PDZ_signaling	209..289	CDD:238492	24/84 (29%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	323..380		3/56 (5%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	444..464		5/19 (26%)
		HN_PDZD7_like	554..630	CDD:259824	22/92 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	754..864		14/51 (27%)
		PDZ_signaling	860..948	CDD:238492
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	943..1033

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810