DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ssp6 and PDZD3

DIOPT Version :9

Sequence 1:	NP_001286952.1	Gene:	ssp6 / 38694	FlyBaseID:	FBgn0035676	Length:	866	Species:	Drosophila melanogaster
Sequence 2:	XP_011541302.1	Gene:	PDZD3 / 79849	HGNCID:	19891	Length:	571	Species:	Homo sapiens

Alignment Length:	222	Identity:	53/222 - (23%)
Similarity:	85/222 - (38%)	Gaps:	77/222 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   123 PDE---DRRRRTIIVEKKNNSYGFTLQSYGIHYKRDEELEMITY-VDYVEYGGPAYRAGMREGDV 183
            ||.   :|.|..::.:::..|:||.||         :||....: |..|:.|..|.|.|::|||.
Human   105 PDPWSLERPRFCLLSKEEGKSFGFHLQ---------QELGRAGHVVCRVDPGTSAQRQGLQEGDR 160

  Fly   184 ILSINGKDMEKADHKTIVEFIKQCDTRMRMVVLFEDCVRKVDLHMRYIQLQSMLQQKMNELERVH 248
            ||::|...:|..|:..:|..|:....|:                     |.::|.:..:::.|..
Human   161 ILAVNNDVVEHEDYAVVVRRIRASSPRV---------------------LLTVLARHAHDVARAQ 204

  Fly   249 LRERELLEGKWKTHSLPARKKANANTSPSDGEGVSPT---EVAGEAGF-----------YRPALS 299
            |.|                   :|:..|:.|.||.|.   .|..|.||           :...||
Human   205 LGE-------------------DAHLCPTLGPGVRPRLCHIVKDEGGFGFSVTHGNQGPFWLVLS 250

  Fly   300 TEDVPNIAARQHGVGGPGIIPPPAQFM 326
            |..    ||.:.||      ||.|:.:
Human   251 TGG----AAERAGV------PPGARLL 267

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ssp6	NP_001286952.1	PDZ_signaling	130..216	CDD:238492	24/86 (28%)
PDZD3	XP_011541302.1	PDZ_signaling	113..193	CDD:238492	26/109 (24%)
		PDZ_signaling	221..298	CDD:238492	15/57 (26%)
		PDZ	326..411	CDD:214570
		PDZ_signaling	466..545	CDD:238492
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900