DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ssp6 and Pdzd2

DIOPT Version :9

Sequence 1:	NP_001286952.1	Gene:	ssp6 / 38694	FlyBaseID:	FBgn0035676	Length:	866	Species:	Drosophila melanogaster
Sequence 2:	NP_001074533.1	Gene:	Pdzd2 / 68070	MGIID:	1922394	Length:	2796	Species:	Mus musculus

Alignment Length:	988	Identity:	178/988 - (18%)
Similarity:	299/988 - (30%)	Gaps:	331/988 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 IATAASSAATTAAAVSISASNATSVGSLIAAACQQEQ------PHPHQHYSQSQQQHLYHQS--- 68
            :...|.:.|...|..|:..:....||.....||....      |...|.:|......|.|::
Mouse  1568 VPAQAPAQAAGGAVPSVQQTVREPVGDACEKACFMTGASNTCIPGSSQPFSFLDVSSLEHETWAG 1632

  Fly    69 -HQQASHY---------VNGTGSLGRLKFHKSLDASDEEIEYAQLSRSTHILGRHKSERYLASNP 123
             ....||.         |:.|||:               :..:|.|::|...|   :..::..||
Mouse  1633 VQTSRSHMPGCAEETLAVSSTGSV---------------VGDSQPSQTTRPCG---NPPFVLRNP 1679

  Fly   124 DEDRRRRTIIVEKKNNSYGFTLQSYGIHYKRDEELEMITYVDYVEYGGPAYRAGMREGDVILSIN 188
            |            ..|..|..|...|...|..:...:::.|..:...||      :.|:.:|:
Mouse  1680 D------------MVNGLGQDLLDEGTPDKGADASHVMSSVYALGAEGP------KNGEAVLA-- 1724

  Fly   189 GKDMEKADHKTIVEFIKQCDTRMRMVVL--FEDCVRKVDLHMRYIQLQSMLQQ----------KM 241
              ::..|....:...:::..|..|..::  |:| :.| |....::|.:|..:|          |.
Mouse  1725 --NLHIAKGGNLDGLLQKPKTTSRRPIMTWFKD-INK-DSQGAHLQSKSEKEQPSMLAMSPGSKG 1785

  Fly   242 NELERVHLRERELLEGKWKTHSLPARKKA--NANTSPSDGEGVSPTEVAGEAGFYRPALSTEDVP 304
            |.:...|.:      |.....|.|.|:|:  |.:.||.     ||.|          .||....|
Mouse  1786 NTVNPSHRK------GMAVPKSPPPRQKSQENKDLSPK-----SPVE----------TLSNCQKP 1829

  Fly   305 NIAARQHGVGGPGIIPPPAQFMLTYHYLDPTYRYVLRPTHGSSEEFVDGLGLQRSSSDHQ----- 364
            ..:.:...:.......|.|.              |..|..|             ..:||:
Mouse  1830 KGSPKLKRLNSKSKASPEAP--------------VASPAKG-------------GRTDHRKSLPS 1867

  Fly   365 PPAQRYVLQQTES--VDANSMTQPTTTAPTQYHSTTGGSVKPPAPPPRTCEKHKPP--------- 418
            |.|...:|.:..|  :......:|..||        |.:.|||...|.:    |||
Mouse  1868 PQAAHKMLSKAVSHRLHIADQEEPKNTA--------GDTSKPPQCVPES----KPPLAASGSLRT 1920

  Fly   419 ----------AKP---PKPEKEKSSGKHCHVG---HSCNPCLGHFR-WKSAEKSAVPAPDNVSLD 466
                      ..|   |||..|:.:....|:.   .|...|....| .:...:..||..::.|:.
Mouse  1921 SASDTSIRTITSPLTSPKPLPEQGANNRFHMAVYLESDTSCPATSRPPRYGPEGKVPHANSGSVS 1985

  Fly   467 AYDLASPCCDTHCVPSRRRH-------RQHKEHTHKH--------------KHRDRERVES---- 506
                          ||..|.       ||.|:.||..              ..:..|::.|
Mouse  1986 --------------PSASRTNIALAGVRQSKQFTHSRVDLVLTEAAQPQGISEKGTEKMASDPLE 2036

  Fly   507 --KEQRVRPKSTSHASPNANGGAGSGHHHHHHHHHHSHEQQQQQQQQQQQQQQQQQQQQQQQPIQ 569
              .:.::...|:.....||.|....|             ..::.....|...|::...:.:|..:
Mouse  2037 RTNQLKIIEISSERMPKNACGDKPPG-------------SDRKGGFLTQSNCQEKSSVRLRQSAE 2088

  Fly   570 TVPHHHHYPHQMHNPCQVQSQSGSTRSRY--FDLASGLASHCSLHSCTSSEFATGDTASYTTSIS 632
            :.|...|:|     |.|........|..|  ..|||...|...|.| ...:::.|.::....|:.
Mouse  2089 SSPKQPHFP-----PSQASQGEQEMRWSYSMARLASSSPSAPQLPS-KMPDYSQGKSSQMPASVG 2147

  Fly   633 T------------DTLFWDPTSET------AQSRQHSTK---SRQSYEQQPQQQQPT-------H 669
            .            :..::.|...|      ||...|..:   |..|....||..|.|       .
Mouse  2148 VPKNGVPVGLAGEEPPYFTPRPATRTYSMPAQFSSHFGREGLSPPSPSHSPQDPQVTAMSGSLSE 2212

  Fly   670 QGHHHHHHHQGDYHQRYHVTTTQMQP------------------------------QQIYPNT-- 702
            :......:.||.|..:..:.|.:..|                              :|.:|:.
Mouse  2213 KSAKGVTNEQGVYSVKPLLETLRNPPPVDVGDVSAVPEASGLIPDKLKVTRRHYYCEQSWPHEST 2277

  Fly   703 --IAYVQKPKSWDNLANKAGFNVGYGYLDTVAVKPAIKMQIAQQRHSMPRRNPYGRYSTYGDVEN 765
              .:..|:.||::||||.          |..|.|.|....:     |:..:.|..|.|:
Mouse  2278 SFFSVKQRIKSFENLANS----------DRPAAKSATSPFL-----SVSSKPPVNRRSS------ 2321

  Fly   766 YAPPPTEFVGELTTTTTTTITAKSTEELLAACDCLTPQQQAAIKAAQYQLSQNQK-----LSHQN 825
                     |.:|:...:..||:|....|::|.    :.|:...:...|::::..     :|.||
Mouse  2322 ---------GSITSGRPSDGTARSLRRSLSSCS----ENQSEASSLLPQMTKSPSSVTLTVSRQN 2373

  Fly   826 SCQLGYYSHLPRP 838
            ..:.....|.|.|
Mouse  2374 PPETNNKGHSPDP 2386

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ssp6	NP_001286952.1	PDZ_signaling	130..216	CDD:238492	13/85 (15%)
Pdzd2	NP_001074533.1	PDZ_signaling	335..416	CDD:238492
		PDZ_signaling	591..672	CDD:238492
		PDZ_signaling	729..813	CDD:238492
		PHA03307	1050..>1355	CDD:223039
		PHA03247	<1197..1562	CDD:223021
		PDZ_signaling	2581..2663	CDD:238492
		PDZ	2709..2791	CDD:214570
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810