DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ssp6 and dysc

DIOPT Version :9

Sequence 1:	NP_001286952.1	Gene:	ssp6 / 38694	FlyBaseID:	FBgn0035676	Length:	866	Species:	Drosophila melanogaster
Sequence 2:	NP_001261810.1	Gene:	dysc / 39533	FlyBaseID:	FBgn0264006	Length:	1254	Species:	Drosophila melanogaster

Alignment Length:	725	Identity:	151/725 - (20%)
Similarity:	225/725 - (31%)	Gaps:	313/725 - (43%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 AAVSISASNATSVGSLIAAACQQ---EQPH-------------PHQHY--------------SQS 59
            ||...|.|:.:.:|..:....::   :.||             |..||              .|.
  Fly   683 AATGRSPSSDSGLGMTVTDIYKRPALQLPHRPMSAGPILHRSQPASHYQTGSNQSSSSLSPPQQQ 747

  Fly    60 QQQHLYHQSHQQASHYVNGTGS-----------LG--RLKFHKSLDASDEEI------------- 98
            |||..::|.|..:..::.|.|.           ||  :|||.::.|...:|.
  Fly   748 QQQQQHYQPHHASLRHLGGIGGNVGSGRHHHHPLGPSQLKFRQTKDNQQQEYGCDEHRTRRGSET 812

  Fly    99 ---EY---------AQLSRSTH-------ILG-----RHKSERYLAS--------------NPD- 124
               ||         .:||||..       :||     ||:|.:.|::              ||:
  Fly   813 LLPEYEPDAEQELATKLSRSFDMKEEGGTLLGDKGVRRHQSMQRLSAEQNGGSTTEQTHEHNPNV 877

  Fly   125 --EDRRRRTIIVEKKNNSYGFTLQSYGIHYKRDEELEMITYVDYVEYGGPAYRA-GMREGDVILS 186
              :.|....|.|:|.....|..::. |.:.|..     :..:..:...|.|:.| |:..|.:||.
  Fly   878 VPDHRGNLHITVKKTKPILGIAIEG-GANTKHP-----LPRIINIHENGAAFEAGGLEVGQLILE 936

  Fly   187 INGKDMEKADHKTIVEFIKQCDTRMRMVVLFEDCVRKVDLHMRYIQL-QSMLQQKMNE---LERV 247
            ::|..:|...|:.:...|.:|....          .|.::....::. :|.|:.|...   ||.
  Fly   937 VDGTKVEGLHHQEVARLIAECFANR----------EKAEITFLVVEAKKSNLEPKPTALIFLEAX 991

  Fly   248 HL--------RERELLE--GKWKTHSLPARKKANANTSPSDGEGVSPTEVAGEAGFYRPALSTED 302
            ||        .||:.||  .:|                     |:..||.        |......
  Fly   992 HLLALPASDPLERQKLEFLYEW---------------------GIDLTET--------PKPMPTP 1027

  Fly   303 VPNIAARQHGVGGPGIIPPPAQFMLTYHYLDPTYRYVLRPTHGSSEEFVDGLGLQRSSSDHQP-- 365
            :|...|:.         |||....| ::.::..|        |||          .:.|:|||
  Fly  1028 IPLTKAKN---------PPPLPHEL-HNNINSQY--------GSS----------AALSNHQPHQ 1064

  Fly   366 -----PAQRYVLQQTESVDANSMTQPTTTAPTQYHSTTG------GSVKPPAPPPRTCEKHKPPA 419
                 |.|    ||.:...:|:.|..|.:..||...|||      ||.:...|
  Fly  1065 HTHPHPQQ----QQQQQQHSNTKTPNTNSNKTQGTPTTGTGAATTGSKQQQQP------------ 1113

  Fly   420 KPPKPEKEKSSGKHCHVGHSCNPCLGHFRWKSAEKSAVPAPDNVSLDAYDLASPCCDTHCVPSRR 484
                             |::.|                 .|...|.:|            .|:|.
  Fly  1114 -----------------GNTTN-----------------TPTKASREA------------TPTRE 1132

  Fly   485 RHRQHKEHTHKHK--------------------------HRDRER--VESKEQRVRPKSTSHASP 521
            :|.||...|.:|:                          ||||::  .|.:|||.|.....|...
  Fly  1133 QHHQHATPTREHQQQTPTRQQQLQREQQQQLQREQQQQHHRDRQQHFREQREQREREYQHEHEHE 1197

  Fly   522 NANGGAGSGHHHHHHHHHHSHEQQQQQQQQQQQQQQQQQQQQQQQPIQTVPHHHHYPHQMHNPCQ 586
                     .|||||||...|||.|.|...|...|.|              |||.|..|..:  |
  Fly  1198 ---------QHHHHHHHREHHEQHQHQHGHQHHPQHQ--------------HHHQYSSQQQH--Q 1237

  Fly   587 VQSQSGSTRS 596
            ..|.|.|.:|
  Fly  1238 RYSSSNSYKS 1247

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ssp6	NP_001286952.1	PDZ_signaling	130..216	CDD:238492	18/86 (21%)
dysc	NP_001261810.1	PDZ_signaling	294..380	CDD:238492
		PDZ_signaling	466..543	CDD:238492
		HN_L-whirlin_R2_like	573..653	CDD:259823
		PDZ_signaling	886..971	CDD:238492	19/100 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.810