DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ssp6 and GRID2IP

DIOPT Version :9

Sequence 1:	NP_001286952.1	Gene:	ssp6 / 38694	FlyBaseID:	FBgn0035676	Length:	866	Species:	Drosophila melanogaster
Sequence 2:	NP_001138590.1	Gene:	GRID2IP / 392862	HGNCID:	18464	Length:	1211	Species:	Homo sapiens

Alignment Length:	980	Identity:	189/980 - (19%)
Similarity:	313/980 - (31%)	Gaps:	311/980 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    67 QSHQQASHYVNGTGSLGRL-KFHKSLDASDEEIEYAQLSRSTHILGRHKSERYLAS--------N 122
            :.|:.....|...|.||:| :..::..|.       :|.||.   ...:.||.|.|        .
Human   200 KKHRARFDEVVSQGLLGKLCRARRAQGAQ-------RLRRSR---SEERPERLLVSTRASAPPRR 254

  Fly   123 PDE--DRR--------------RRTIIVEKKNNSYGFTLQSYGIHYKRDEELEMITYVDYVEYGG 171
            |||  .||              |||:.|.|.|.|:||||:.:|           ..:::.|..|.
Human   255 PDEPPPRRASLLVGGLAGPGGARRTVRVYKGNKSFGFTLRGHG-----------PVWIESVLPGS 308

  Fly   172 PAYRAGMREGDVILSINGKDMEKADHKTIVEFIKQCDTRMRMVVLFEDCVRKVDLHMRYIQLQSM 236
            ||..|.::.||.||.:||.||....|..:|..: |....|..:|:.|..|              .
Human   309 PADNAALKSGDRILFLNGLDMRNCSHDKVVSML-QGSGAMPTLVVEEGLV--------------P 358

  Fly   237 LQQKMNELERVHLRERELLEGKWKTHSLPARKKANANTSPSDGEG-VSPTEVAG-----EAGFYR 295
            .....:.|:..: ....|...:|....||:..:....|.....|. ::|.|..|     |:.|..
Human   359 FASDSDSLDSPN-PSSALTSLQWVAEILPSSIRVQGRTFSQQLEHLLTPPERYGVCRALESFFQH 422

  Fly   296 PALST--EDVPNIAARQHGVGGPGIIPPPAQFMLTYHYLDPTYRYVLRPTHGSSEEFVDGLGLQR 358
            ..:.|  .||           .|.:..|..|.:..:.|...||    .......|:....||...
Human   423 RNIDTLIVDV-----------YPVLDTPAKQVLWQFIYQLLTY----EEQELCQEKIACFLGYTA 472

  Fly   359 SSSDHQP-------PAQRYVLQQTESVDANSMTQ----------------------PTTTAPTQY 394
            .:::.:|       |...  .|...|:.|:||.:                      |....|.:.
Human   473 MTAEPEPELDLESEPTPE--PQPRSSLRASSMCRRSLRSQGLEAGLSCGPSECPEMPLPLIPGER 535

  Fly   395 HSTTGGSVKPPAPPPR----------------------TCEKHKPPAKPPKPEKEKSSGKHCHVG 437
            .:..|.|: |..|.|:                      |..|.:  |.||.|....::|.....|
Human   536 QAGDGTSL-PETPNPKMMSAVYAELESRLNSSFKGKMGTVSKSR--ASPPGPSPAVTTGPRTLSG 597

  Fly   438 HS----------C-NP-CLGHFRWKSAEKSAVPAPDNVSLDAYDLASP-------CCDTHCVPSR 483
            .|          | :| |.|.....|:.:|...|    |||:....||       |.|:...|..
Human   598 VSWPSERLLPSPCYHPLCSGGLASPSSSESHPYA----SLDSSRAPSPQPGPGPICPDSPPSPDP 658

  Fly   484 RR---HRQHKEHTHKHKHRDRER-VESKEQRVRPKST---SHASPNANGGAGSGHHHHHHHHHHS 541
            .|   .|:....:|..:.||.:| ::...:::.|:.|   ...:|           .:.:.....
Human   659 TRPPSRRKLFTFSHPVRSRDTDRFLDVLSEQLGPRVTIVDDFLTP-----------ENDYEEMSF 712

  Fly   542 HEQQQQQQQQQQQQQQQQQQQQQQ--------------------QPIQTVPHHHHYPHQMHNPCQ 586
            |:.|......::..........::                    .|...:|.|...|..
Human   713 HDDQGSFVTNERSSASDCISSSEEGSSLTYSSISDHIPPPPLSPPPPPPLPFHDAKPSS------ 771

  Fly   587 VQSQSGSTRSRYFDLASGLA--SH---------------CSLHSCTSSEFATGDTASYTTSISTD 634
             :|..|| |.....||..|.  ||               |:....:.   ..|...|.|:.:|..
Human   772 -RSSDGS-RGPAQALAKPLTQLSHPVPPPPPPPLPPPVPCAPPMLSR---GLGHRRSETSHMSVK 831

  Fly   635 TLFWDPTSETAQSRQHSTKSRQSYEQQPQQQQPTHQGHHHHHHHQGDYHQ-----RY-----HVT 689
            .|.|                     :|.:..:.|..|   ......||.:     :|     |..
Human   832 RLRW---------------------EQVENSEGTIWG---QLGEDSDYDKLSDMVKYLDLELHFG 872

  Fly   690 TTQMQPQQIYPNTIAYVQKPKSWDNLANKAGFNVGYGYLDTVAVKPAIKMQIAQQRHSM-PRR-- 751
            |  .:|.:..|....: :|.:..:.|::|..:|... .|..:.:.||   ::.|...|| |||
Human   873 T--QKPAKPVPGPEPF-RKKEVVEILSHKKAYNTSI-LLAHLKLSPA---ELRQVLMSMEPRRLE 930

  Fly   752 --------------NPYGRYSTYGDVENYAPPPTEFVGELTTTTTTTITAKS----------TEE 792
                          :...||..:.:.......|.:||.::.:........:|          |||
Human   931 PAHLAQLLLFAPDADEEQRYQAFREAPGRLSEPDQFVLQMLSVPEYKTRLRSLHFQATLQEKTEE 995

  Fly   793 LLAACDCLTPQQQAAIKAAQYQLSQNQKLSH--QNSCQLGYYSHLPRPTTDVGTSTTSQQVHGAG 855
            :..:.:||        :.|..:|..::||:.  :....:|.|.:..:|.|:   .||..:::...
Human   996 IRGSLECL--------RQASLELKNSRKLAKILEFVLAMGNYLNDGQPKTN---KTTGFKINFLT 1049

  Fly   856 DVQTT 860
            ::.:|
Human  1050 ELNST 1054

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ssp6	NP_001286952.1	PDZ_signaling	130..216	CDD:238492	28/85 (33%)
GRID2IP	NP_001138590.1	PDZ_signaling	14..74	CDD:238492
		HN_L-delphilin-R1_like	133..212	CDD:259820	2/11 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	226..269		13/52 (25%)
		PDZ_signaling	278..353	CDD:238492	29/86 (34%)
		HN_L-delphilin-R2_like	389..468	CDD:259821	17/93 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	478..502		5/25 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	525..549		6/24 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	568..600		8/33 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	618..672		13/57 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	718..783		8/72 (11%)
		FH2	820..1188	CDD:280362	50/277 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900