DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ssp6 and GRIP1

DIOPT Version :9

Sequence 1:	NP_001286952.1	Gene:	ssp6 / 38694	FlyBaseID:	FBgn0035676	Length:	866	Species:	Drosophila melanogaster
Sequence 2:	XP_016874587.1	Gene:	GRIP1 / 23426	HGNCID:	18708	Length:	1188	Species:	Homo sapiens

Alignment Length:	216	Identity:	42/216 - (19%)
Similarity:	84/216 - (38%)	Gaps:	50/216 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 AAAVSISASNATSVGSLIAAACQQE-QPHPHQHYSQSQQQHLYHQSHQ-QASHYVNGTGSLGRLK 86
            :..|.:.....|::|..::....:: :|    ..|..:|..:..:|.| ....|:.....:...|
Human   126 STVVELMKKEGTTLGLTVSGGIDKDGKP----RVSNLRQGGIAARSDQLDVGDYIKAVNGINLAK 186

  Fly    87 FHKSLDASDE--------------EIEY----AQLSRSTHILGRHKSERYLASNPDEDRRRRTII 133
            |.     .||              |:||    ..:..|:.|.                 |...:.
Human   187 FR-----HDEIISLLKNVGERVVLEVEYELPPVSVQGSSVIF-----------------RTVEVT 229

  Fly   134 VEKKNNSYGFTLQSYGIHYKRDEELEMITYVDYVEYGGPAYRAG-MREGDVILSINGKDMEKADH 197
            :.|:.|::||.::. |.|..|::...::  :..|..||||.|.| ::.||.:||::|..:....|
Human   230 LHKEGNTFGFVIRG-GAHDDRNKSRPVV--ITCVRPGGPADREGTIKPGDRLLSVDGIRLLGTTH 291

  Fly   198 KTIVEFIKQCDTRMRMVVLFE 218
            ...:..:|||.....:::.::
Human   292 AEAMSILKQCGQEAALLIEYD 312

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ssp6	NP_001286952.1	PDZ_signaling	130..216	CDD:238492	23/86 (27%)
GRIP1	XP_016874587.1	PDZ_signaling	128..208	CDD:238492	14/88 (16%)
		PDZ_signaling	227..310	CDD:238492	23/85 (27%)
		PDZ_signaling	325..408	CDD:238492
		PDZ_signaling	545..633	CDD:238492
		PDZ_signaling	646..730	CDD:238492
		PDZ_signaling	746..827	CDD:238492
		PDZ_signaling	1062..1142	CDD:238492
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810