Protein Alignment ssp6 and PDZD2

DIOPT Version :9

• Sequence 1: NP_001286952.1
• Gene: ssp6 / 38694
• FlyBaseID: FBgn0035676
• Length: 866
• Species: Drosophila melanogaster
• Sequence 2: XP_005248326.1
• Gene: PDZD2 / 23037
• HGNCID: 18486
• Length: 2873
• Species: Homo sapiens
• Alignment Length: 1165
• Identity: 210/1165 - (18%)
• Similarity: 322/1165 - (27%)
• Gaps: 464/1165 - (39%)

  Fly     5 PMSTSCQS---IATAASSAATTAAAVSISASNATSVGSL-------------------------- 40
            |..|.|.:   ::.:||....|:...|...|:..|..||
Human   676 PSLTPCSTPTHMSRSASPNFNTSGGASAGGSDEGSSSSLGRKTPGPKDRIVMEVTLNKEPRVGLG 740

  Fly    41 IAAACQQEQPHPHQHYSQSQQQHLYHQSHQQASHYVNGTGSLGRLKFHKS-----LDASDEEIEY 100
            |.|.|...:..|...|..|.                 ..||:.:::.:.|     |:.:...:.:
Human   741 IGACCLALENSPPGIYIHSL-----------------APGSVAKMESNLSRGDQILEVNSVNVRH 788

  Fly   101 AQLSRSTH-------------ILGRHKSERYLASNPDEDRRRRTIIVEKKNNS---YGFTLQSYG 149
            |.||: .|             ::|||.:.:......||...|.|....|:.||   .|..|:|..
Human   789 AALSK-VHAILSKCPPGPVRLVIGRHPNPKVSEQEMDEVIARSTYQESKEANSSPGLGTPLKSPS 852

  Fly   150 IHYKRD---EELEMITYVDYVEYGGPAYRAGMREGDVILSINGKDMEKADHKTIVEFIKQCDTRM 211
            : .|:|   .|.|:..|..: :..||.       .|.:::    ..|..||..     ..|.|
Human   853 L-AKKDSLISESELSQYFAH-DVPGPL-------SDFMVA----GSEDEDHPG-----SGCST-- 897

  Fly   212 RMVVLFEDCVRKVDLHMRYIQLQSMLQQKMNELERVHLRERELLEGKWKTHSLPARKKANA---- 272
                                                  .|...|.....||..|.:.:||:
Human   898 --------------------------------------SEEGSLPPSTSTHKEPGKPRANSLVTL 924

  Fly   273 NTSPSDGEGVSPTEVAGEAGFYRPALSTEDVPNIAARQHGVGG---------------------P 316
            .:..:.|.......||.:|..  |. |.:.:.|...||..||.                     |
Human   925 GSHRASGLFHKQVTVARQASL--PG-SPQALRNPLLRQRKVGCYDANDASDEEEFDREGDCISLP 986

  Fly   317 GIIPPPAQFM---------------LTYHYLDPTYRYVL------RPTHGSSEEFVDGLGLQRSS 360
            |.:|.|.:.:               :..|..:...|..|      .|..|||   ||   |:.|.
Human   987 GALPGPIRPLSEDDPRRVSISSSKGMDVHNQEERPRKTLVSKAISAPLLGSS---VD---LEESI 1045

  Fly   361 SDHQPPAQRYVLQQTESVDA--------------------------NSMTQ-PTTT----APTQY 394
            .:....|..|....|:|.:|                          .:.|| ||.|    :|.|.
Human  1046 PEGMVDAASYAANLTDSAEAPKGSPGSWWKKELSGSSSAPKLEYTVRTDTQSPTNTGSPSSPQQK 1110

  Fly   395 HSTTGGSVKPPAPPPRTCEKHKPPAKPP---------------------------------KP-- 424
            ....|...:|.|.....|::.:..|||.                                 :|
Human  1111 SEGLGSRHRPVARVSPHCKRSEAEAKPSGSQTVNLTGRANDPCDLDSRVQATSVKVTVAGFQPGG 1175

  Fly   425 --EKEK----SSGKHCHVGHSCN--PCLGHFRW--------KSAEK------------------- 454
              |||.    ::|..| |..||.  ..|.|...        |:|.:
Human  1176 AVEKESLGKLTTGDAC-VSTSCELASALSHLDASHLTENLPKAASELGQQPMTELDSSSDLISSP 1239

  Fly   455 ----SAVPAPDNVSLDAYDLASPCCDTHCVPSRRRHRQHKEHT-----HKHKHRDRERVE----- 505
                :|.|.|...|:|...::.|  :....|:..|..:.|..:     |:......|:..
Human  1240 GKKGAAHPDPSKTSVDTGQVSRP--ENPSQPASPRVTKCKARSPVRLPHEGSPSPGEKAAAPPDY 1302

  Fly   506 SKEQRVRPKSTSH----------ASPNANGGAGSGHHHHHHHHHHSHEQQQQQQQQQQQQQQQQQ 560
            ||.:.....||.|          |.|.|.|...:|                      ........
Human  1303 SKTRSASETSTPHNTRRVAALRGAGPGAEGMTPAG----------------------AVLPGDPL 1345

  Fly   561 QQQQQQPIQTVPHHH---------HYPHQMHNPCQVQ-SQSGSTRSRYFDLA--------SGLAS 607
            ..|:|:  |..|.:|         |.|.....|..:: :.|.|:|:....|:        .....
Human  1346 TSQEQR--QGAPGNHSKALEMTGIHAPESSQEPSLLEGADSVSSRAPQASLSMLPSTDNTKEACG 1408

  Fly   608 HCSLHSCTSSEFATGDTASYTTSISTDTLFWDPTSETAQSRQHSTKSRQSYEQQPQQQQPTHQGH 672
            |.|.|.|..     |...|..|.|  |:...:..:..|:|....|....|.|...|...|...|
Human  1409 HVSGHCCPG-----GSRESPVTDI--DSFIKELDASAARSPSSQTGDSGSQEGSAQGHPPAGAG- 1465

  Fly   673 HHHHHHQGDYHQRYHVTTTQ-MQPQQIY-PNTIAYVQKPKSWDNLANKAGFNVGYGYLDTVAVKP 735
                  .|...:...|...| ..|::.: ....||.|    |                   |.:|
Human  1466 ------GGSSCRAEPVPGGQTSSPRRAWAAGAPAYPQ----W-------------------ASQP 1501

  Fly   736 AIKMQIAQQRHSMPRRNPYGRY--------------------------STYGDVENYAPPPTEFV 774
            ::...|...:|....:|....|                          |.|||.|:.:..|.
Human  1502 SVLDSINPDKHFTVNKNFLSNYSRNFSSFHEDSTSLSGLGDSTEPSLSSMYGDAEDSSSDPE--- 1563

  Fly   775 GELTTTTTTTI-----------------TAKSTEELLAACD---CLTPQQ-------QAAIKAA- 811
             .||.....:.                 .::|.||.:..|.   |..|..       ||||..|
Human  1564 -SLTEAPRASARDGWSPPRSRVSLHKEDPSESEEEQIEICSTRGCPNPPSSPAHLPTQAAICPAS 1627

  Fly   812 ------QYQLSQNQKLS--HQNSCQLGYYSHLP---RPTTDVGTSTTSQQVHGAGDVQTT 860
                  :|...:....|  .:.:|..|.|:..|   :|::.:..|:...:.|  .|:.|:
Human  1628 AKVLSLKYSTPRESVASPREKAACLPGSYTSGPDSSQPSSLLEMSSQEHETH--ADISTS 1685

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ssp6	NP_001286952.1	PDZ_signaling	130..216	CDD:238492	20/91 (22%)
PDZD2	XP_005248326.1	PDZ_signaling	335..416	CDD:238492
		PDZ_signaling	589..670	CDD:238492
		PDZ_signaling	726..810	CDD:238492	14/101 (14%)
		PDZ_signaling	2623..2694	CDD:238492
		PDZ	2785..2867	CDD:214570

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900