DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ssp6 and Grip2

DIOPT Version :9

Sequence 1:	NP_001286952.1	Gene:	ssp6 / 38694	FlyBaseID:	FBgn0035676	Length:	866	Species:	Drosophila melanogaster
Sequence 2:	NP_612544.2	Gene:	Grip2 / 171571	RGDID:	621668	Length:	1043	Species:	Rattus norvegicus

Alignment Length:	417	Identity:	83/417 - (19%)
Similarity:	136/417 - (32%)	Gaps:	170/417 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly   121 SNPDEDRRRRTIIVEKKNNSYGFTLQSYGIHYKRDEELEMITYVDYVEYGGPAYRAG-MREGDVI 184
            :||....:...:.:.|:.||:||.|:. |.|....:...::  :.||..||||.|.| ::.||.:
  Rat   143 NNPRIISKTVDVSLYKEGNSFGFVLRG-GAHEDLHKSRPLV--LTYVRPGGPADREGSLKVGDRL 204

  Fly   185 LSINGKDMEKADHKTIVEFIKQCDTRMRMVVLFE----DCVRKVDLHMRYIQLQSMLQQKMNELE 245
            |||:|..:..|.|.|.:..::||.......|.::    |.|
  Rat   205 LSIDGIPLHGASHATAIATLQQCSHEALFQVEYDVATPDTV------------------------ 245

  Fly   246 RVHLRERELLEGKWKTHSLPARKKANAN--------TSPSDGEGVSPTEVAGEAGFYR--PALST 300
                                    |||:        .:|....|:|.|     .|.:|  ||::.
  Rat   246 ------------------------ANASGPLVVEIAKTPGSALGISLT-----TGSHRNKPAITI 281

  Fly   301 EDVPNIAARQHGVGGPGIIPPPAQFMLTYHYLDPTYRYVLRPTHGSSEEFVDGLGLQRSSSDHQP 365
            :.:                 .||..                              :.||.:.|
  Rat   282 DRI-----------------KPASV------------------------------VDRSGALH-- 297

  Fly   366 PAQRYVLQQTESVDANSMTQPTTTAPTQYHSTTGGSVK---PPAPPPRTCEKHKPPAKPPKPEK- 426
             |..::|    ::|..|....:....|:..::....|:   .|||..|.      |.|||:..:
  Rat   298 -AGDHIL----AIDGTSTEHCSLVEATKLLASVTEKVRLEILPAPQSRR------PLKPPEAVRI 351

  Fly   427 EKSSGKH--------CHVGHSCNPCLGHFR---W------KSAEKSAVPAPDNVSLDAYDLASPC 474
            ::|...|        ||     :|...|.|   |      :|...|:.|    .|....:.|.||
  Rat   352 QRSEQLHHWDPCVPSCH-----SPRPSHCRAPTWAPGGQDQSRSVSSTP----FSSPTMNPAFPC 407

  Fly   475 CDTHCVP---------SRRRHRQHKEH 492
            .:...:|         :.||.::.|||
  Rat   408 ANASTLPRGPMSPRTTAGRRRQRRKEH 434

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ssp6	NP_001286952.1	PDZ_signaling	130..216	CDD:238492	27/86 (31%)
Grip2	NP_612544.2	PDZ_signaling	51..133	CDD:238492
		PDZ_signaling	153..236	CDD:238492	27/85 (32%)
		PDZ_signaling	251..334	CDD:238492	19/141 (13%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	371..450		16/68 (24%)
		PDZ_signaling	456..544	CDD:238492
		PDZ_signaling	557..640	CDD:238492
		PDZ_signaling	657..737	CDD:238492
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	745..769
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	786..863
		PDZ_signaling	941..1020	CDD:238492
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900