DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ssp6 and FRMPD2

DIOPT Version :9

Sequence 1:	NP_001286952.1	Gene:	ssp6 / 38694	FlyBaseID:	FBgn0035676	Length:	866	Species:	Drosophila melanogaster
Sequence 2:	NP_001018081.4	Gene:	FRMPD2 / 143162	HGNCID:	28572	Length:	1309	Species:	Homo sapiens

Alignment Length:	425	Identity:	84/425 - (19%)
Similarity:	137/425 - (32%)	Gaps:	155/425 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    68 SHQQASHYVNGTGSLGRLKFHKSLDASDEEI---------EYAQLSRSTHILGRHKSERYLASNP 123
            :|:||...:.|.|.:.||...:.:..|.::.         |...:|..|.:.||..|...:...|
Human  1012 THKQAVQCLTGPGQVARLVLERRVPRSTQQCPSANDSMGDERTAVSLVTALPGRPSSCVSVTDGP 1076

  Fly   124 DEDRRRRTIIVEKKNNSYGFTL----QSYGIHYKRDEELEMITYVDYVEYGGPAYRAG-MREGDV 183
                 :..:.::|..|..||:.    :....|.|.|     :..:..:..|.||...| :..||:
Human  1077 -----KFEVKLKKNANGLGFSFVQMEKESCSHLKSD-----LVRIKRLFPGQPAEENGAIAAGDI 1131

  Fly   184 ILSINGKDMEKADHKTIVEFIKQCDTRMRMVVLFEDCVRKVDLHMRYIQLQSMLQQKMNELERVH 248
            ||::||:..|.                    ::|::.     ||:    |:...|:....|.|..
Human  1132 ILAVNGRSTEG--------------------LIFQEV-----LHL----LRGAPQEVTLLLCRPP 1167

  Fly   249 LRERELLEGKWKTHSLPARKKANANTSPSDGEGVSPTEVAGEAGFYRPALSTEDVPNIAARQHGV 313
            ......||.:|:|..|.|.|:....|...     |.|.         |.|..||
Human  1168 PGALPELEQEWQTPELSADKEFTRATCTD-----SCTS---------PILDQED----------- 1207

  Fly   314 GGPGIIPPPAQFMLTYHYLDPTYRYVLRPTHGSSEEFVDGLGLQRSSSDHQPPAQRYVL-----Q 373
                                 ::|....|..|      :||||:..||      |:.:.     |
Human  1208 ---------------------SWRDSASPDAG------EGLGLRPESS------QKAIREAQWGQ 1239

  Fly   374 QTESVDANSMTQPTTTAPTQYHSTTGGSVKPPAPPPRTCEKHKPPAKPPKPEKEKSSGKHCHVGH 438
            ..|...|:|:|          ||        |...|..|:.|:        |:::|:
Human  1240 NRERPWASSLT----------HS--------PESHPHLCKLHQ--------ERDEST-------- 1270

  Fly   439 SCNPCLGHFRWKSAEKSAVPAPDNVSLDAYDLASP 473
                 |.....|...::.....|.:.|..|..:||
Human  1271 -----LATSLEKDVRQNCYSVCDIMRLGRYSFSSP 1300

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ssp6	NP_001286952.1	PDZ_signaling	130..216	CDD:238492	18/90 (20%)
FRMPD2	NP_001018081.4	KIND	15..197	CDD:214801
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	214..249
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	266..302
		B41	346..550	CDD:214604
		FERM_C_PTPH13	546..647	CDD:270008
		PDZ_signaling	773..857	CDD:238492
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	859..880
		PDZ	947..1034	CDD:214570	7/21 (33%)
		PDZ	1078..1167	CDD:214570	25/122 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1204..1228		9/61 (15%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810