DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ssp6 and whrna

DIOPT Version :9

Sequence 1:	NP_001286952.1	Gene:	ssp6 / 38694	FlyBaseID:	FBgn0035676	Length:	866	Species:	Drosophila melanogaster
Sequence 2:	XP_002665968.3	Gene:	whrna / 100334777	ZFINID:	ZDB-GENE-091118-27	Length:	939	Species:	Danio rerio

Alignment Length:	548	Identity:	107/548 - (19%)
Similarity:	162/548 - (29%)	Gaps:	178/548 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   109 ILGRHKSERYLASNPDEDRRRRTIIV---EKKNNSYGFTLQSYGIHYKRDEELEMITYVDYVEYG 170
            :|..|:|.....|| .:.|....::.   |||.|......:|.|:..:...|..:..|:..|:.|
Zfish   286 LLAEHRSATLRRSN-SQGRSHMQLLQDGDEKKVNLVLDDGRSLGLMIRGGAEYSLGIYITGVDRG 349

  Fly   171 GPAYRAGMREGDVILSINGKDMEKADHKTIVEFIKQCDTRMRMVVLFEDCVRKVDLHMRYIQLQS 235
            ..|...|::.||.||.:||:......|                           |..:|.::...
Zfish   350 SAAECGGIKVGDQILEVNGRSFLSIPH---------------------------DEAVRVLKSSH 387

  Fly   236 MLQQKMNELERVHLRERELLEGKWKTHSLPARKKANAN-TSPSDGEGVSPTEVAGEAGFYRPALS 299
            .|...:.::.|:......:.|.||...|..:...|::: |..|..:|.|   .:.:.|||:....
Zfish   388 HLMMTVKDVGRLPHTRTVVGETKWIASSQISDSSASSSVTGISLDQGAS---TSAKGGFYKGVAG 449

  Fly   300 TEDVPNIAARQHGVGGPGIIPPPAQFML------TYHYLDPTYR-------------YVLRPTHG 345
            ::...:....|    ...::...|:.:|      |..|....||             :.|..||.
Zfish   450 SQVTLSSLVNQ----SRAMLEEQARHLLTEPERQTMGYYIQEYRDGHVGVEQLVMALFELFNTHA 510

  Fly   346 S----SE----------EFVDGLGLQR----------SSSDHQPPAQRYVLQQT-ESVDANSMTQ 385
            .    ||          |..|||.|:|          ..:..|..........| .|..|:.||.
Zfish   511 KFSLLSEVRGIVTPQDVEKFDGLVLRREIDALKARQGGGAGFQDSFSMVSYPDTLASSSASFMTN 575

  Fly   386 PTTTAP--------------------------TQYHSTTGG--SVKPPAPPPRTCEKHKPPAKPP 422
            .|.::.                          .:.|||:..  |.|||.||..   :.:|..|..
Zfish   576 TTLSSARNDGVAENNGEQGSLEHSNALPDISLDEVHSTSDSPPSFKPPPPPGL---QRRPSRKAT 637

  Fly   423 KPEKEKSSG----------KHCHVGHSCNP----------------------------CLGHF-- 447
            ..::..||.          ...|...|.:|                            .:|.|
Zfish   638 LSKRPSSSSSQSGLYFTAPSRSHTRESKHPKAPKAFMSPPGTLKIDVPASQLSVVSQHPIGPFPR 702

  Fly   448 -----RWKSAEKSA--------VPAPDN-VSLDAYDLASPCCDTHCVPSRRRHRQHKEHTHKHKH 498
                 :.|.|:.|:        ||||.. .......|..|.|.....||.....||......|
Zfish   703 VQSPNKAKPAQSSSPIPPPAPNVPAPPGPPPPPPPPLPPPSCPDKPTPSSPASNQHFVMVEVH-- 765

  Fly   499 RDRERVESKEQRVRPKSTSHASPNANGG 526
              |...|.....|||      .|...||
Zfish   766 --RPNAEPDVNEVRP------LPQVRGG 785

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ssp6	NP_001286952.1	PDZ_signaling	130..216	CDD:238492	19/88 (22%)
whrna	XP_002665968.3	HN_L-whirlin_R1_like	25..102	CDD:259822
		PDZ_signaling	174..255	CDD:238492
		PDZ_signaling	314..394	CDD:238492	22/106 (21%)
		HN_L-whirlin_R2_like	459..538	CDD:259823	17/82 (21%)
		PDZ_signaling	848..919	CDD:238492
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810