DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ssp6 and pdzd7a

DIOPT Version :9

Sequence 1:	NP_001286952.1	Gene:	ssp6 / 38694	FlyBaseID:	FBgn0035676	Length:	866	Species:	Drosophila melanogaster
Sequence 2:	NP_001177686.1	Gene:	pdzd7a / 100332580	ZFINID:	ZDB-GENE-090313-191	Length:	954	Species:	Danio rerio

Alignment Length:	567	Identity:	104/567 - (18%)
Similarity:	195/567 - (34%)	Gaps:	148/567 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    55 HYSQSQQQHLYHQSHQQASHYVNGTGSLGRLKFHKSLDASDEEIEYAQLS-RSTHILGRHKSERY 118
            |.|.:.::.:.:.:|..|....:||.:|.|. .||.        :..|.. ||:..:||......
Zfish     3 HSSDTARKDMTNGAHPSAQPGPSGTSTLPRY-LHKK--------QQRQRGVRSSSPMGRVILINA 58

  Fly   119 LASNPDEDRRRRTIIVEKKNNSY-GFTLQSYGIHYKRDEELEMITYVDYVEYGGPAYRAGMREGD 182
            .....|:.....||.|:|..:.: ||:::....|       .:..:|..||....|..||:..||
Zfish    59 PVDGGDDSEDIHTITVDKSEDGHLGFSVRGGSEH-------GLGIFVSKVEDDSTAEMAGLCVGD 116

  Fly   183 VILSINGKDMEKADHKTIVEFIKQCDTRMRMVVLFEDCVRKVDL--HMRYIQLQSMLQQKMNELE 245
            .::.:||..:|.....:.|:.:.. :.|:|||      ||:|..  .:||      .::|...::
Zfish   117 KLVEVNGISLESITMSSAVKVLTG-NNRLRMV------VRRVGKVPGIRY------SKEKTTWVD 168

  Fly   246 RVHLRERELLEGKWKTHSLPA-----RKKANANTSPSD-------------GEGV-----SPTEV 287
            .:|  .|.::|...:|.|..:     |:..:..|:..|             |.|:     .|..:
Zfish   169 LIH--RRMVVEESGRTPSEASSDGALRRIVHLYTTSDDYCLGFNIRGGKEFGLGIYVSKLDPGGL 231

  Fly   288 AGEAG-------FYRPALSTEDVPNIAARQHGVGGPGIIPPPAQFMLT---------YHYLDPTY 336
            |.:.|       .....:|.||:.:..|.:       ::......|||         |..:...|
Zfish   232 AEQNGIKMGDQILAANGVSFEDITHSNAVE-------VLKSHTHVMLTIKEAGRYPAYKEMVAEY 289

  Fly   337 RYVLRPTHG---SSEEFVDGLGLQRSSSDHQPPAQRYVLQQ--------TESVDANSMTQPTTTA 390
            .::.:..:|   ||.:..|......|.|...|.:....|.|        :|.||....|:..:..
Zfish   290 SWLNKLANGGQPSSSQGSDSYSSTSSLSSGTPVSSLSGLSQVTFPPAFGSEMVDVCISTEDRSRR 354

  Fly   391 PTQYHSTTGGSVKPPAPP--PRTCEKHKPPAKPPKPEKEKSSGKHCHVGHS-CNPCLGHFR---W 449
            |:.....|.....|..|.  .||       ::....|..:..|:...:..: ......|.|   :
Zfish   355 PSSERIETAIQTDPQDPDTISRT-------SRVMSTETSRMVGETVLLKDTVIRRGTAHSRTRTF 412

  Fly   450 KSAEKSAVPAP-------------------DNVSLDAYDLASPCCDTHCVPSRRRHRQHKEHTHK 495
            .:.:|..:.:|                   .::::..:..|:......|..:.|..::.|:...|
Zfish   413 SAGDKETLDSPKTAVLMALSKPRKAIRRSQSHITVSEFWFATERASCLCGCTSRSRQEDKQKKRK 477

  Fly   496 HKH------------------------RDRERVESKEQRVRPKSTSH 518
            |:.                        |.|||..|::::...:...|
Zfish   478 HQKGKVETEGSTLQRSKTFVTLPFKSGRRRERSSSRDRKDTGREDGH 524

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ssp6	NP_001286952.1	PDZ_signaling	130..216	CDD:238492	23/86 (27%)
pdzd7a	NP_001177686.1	PDZ_signaling	69..149	CDD:238492	23/93 (25%)
		PDZ_signaling	194..274	CDD:238492	14/86 (16%)
		HN_PDZD7_like	568..645	CDD:259824
		PDZ_signaling	860..948	CDD:238492
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910