DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dscamb and dpr3

DIOPT Version :9

Sequence 1:	XP_009289749.1	Gene:	dscamb / 386937	ZFINID:	ZDB-GENE-031118-67	Length:	2020	Species:	Danio rerio
Sequence 2:	NP_001014459.2	Gene:	dpr3 / 3346208	FlyBaseID:	FBgn0053516	Length:	522	Species:	Drosophila melanogaster

Alignment Length:	338	Identity:	70/338 - (20%)
Similarity:	115/338 - (34%)	Gaps:	95/338 - (28%)

- Green bases have known domain annotations that are detailed below.

Zfish   204 TGETRQSNSARLLLSEPVD---SAPVILDGFERKEV-MVGH-RVELPCKASGHPPPRYRWLR--- 260
            |...|:.:.|....|:..|   |.|:...|..|... ..|| ...:.|:..........|:|
  Fly   212 TDAKRERSGAADEESQDADTSQSLPIFDFGMPRNITGRTGHTEAIIKCRVDSLHDKSVSWIRKRD 276

Zfish   261 ------DNSPLESDSRYHQSVS------GLLIEATRPSDAGSYVCEVWNS---FGNAKVVGRLVV 310
                  ..:...||.|:..:.|      .|.::|....|:|.|.|:| |:   ...|..:..:.:
  Fly   277 LHILTVGTATYTSDKRFQVTESKDSREWTLHVKAPLAKDSGIYECQV-NTEPKMSMAFQLNIIEI 340

Zfish   311 KQPLKAVVS-PRKVRGSVGSQVSLFCSV---TGSDEFDITWYRNAEKIYQGINVRITGINNENLV 371
            ....|||:| |..:....||.:.|.|.|   :..|...|.|||                 .|:::
  Fly   341 SPDAKAVISGPPDLHFKAGSAIILNCLVQQPSVKDIGPIYWYR-----------------GEHMI 388

Zfish   372 MEGMAKSDGGAYQCFARNGKMSTQDLVQVVLEDGTPKILSAFSEKVVSPNEPISLVCHVKGTPLP 436
            ....|                          :||.|:|.:...|             |.:|.|..
  Fly   389 TPFDA--------------------------DDGQPEIPAGRGE-------------HPQGIPED 414

Zfish   437 TVTWTLDDDPVIKDSNHRMD---RIITTE--GHVL-SYLNVSHTQVSDGGVYRCTCNNSAGSVSY 495
            |     ..:.::.:.:.:|:   ||....  |..| |.|.:|:.|.:|.|.|.|....::.:...
  Fly   415 T-----SPNDIMSEVDLQMEFATRIAMESQLGDTLKSRLRISNAQTTDTGNYTCQPTTASSASVL 474

Zfish   496 QARINVRGPASIR 508
            ...||...||:::
  Fly   475 VHVINDENPAAMQ 487

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dscamb	XP_009289749.1	I-set	132..198	CDD:254352
		I-set	225..310	CDD:254352	21/104 (20%)
		IGc2	239..300	CDD:197706	17/79 (22%)
		IG_like	320..400	CDD:214653	13/82 (16%)
		IGc2	328..391	CDD:197706	12/65 (18%)
		IG_like	417..501	CDD:214653	18/89 (20%)
		Ig	424..498	CDD:143165	17/79 (22%)
		IG_like	511..592	CDD:214653
		IGc2	518..576	CDD:197706
		I-set	595..685	CDD:254352
		Ig	612..682	CDD:143165
		I-set	689..785	CDD:254352
		Ig7_DSCAM	706..785	CDD:143211
		IG_like	795..883	CDD:214653
		Ig	803..890	CDD:299845
		FN3	887..980	CDD:238020
		FN3	987..1084	CDD:238020
		FN3	1092..1185	CDD:238020
		FN3	1190..1279	CDD:238020
		IGc2	1302..1367	CDD:197706
		FN3	1398..1471	CDD:238020
		FN3	1485..1557	CDD:238020
dpr3	NP_001014459.2	Ig	243..330	CDD:299845	18/87 (21%)
		IG_like	243..329	CDD:214653	18/86 (21%)
		Ig	350..464	CDD:299845	34/174 (20%)
		IG_like	<441..477	CDD:214653	10/35 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810