Protein Alignment CG42269 and SLC22A13

DIOPT Version :9

• Sequence 1: NP_648019.2
• Gene: CG42269 / 38689
• FlyBaseID: FBgn0259164
• Length: 662
• Species: Drosophila melanogaster
• Sequence 2: NP_004247.2
• Gene: SLC22A13 / 9390
• HGNCID: 8494
• Length: 551
• Species: Homo sapiens
• Alignment Length: 587
• Identity: 179/587 - (30%)
• Similarity: 291/587 - (49%)
• Gaps: 58/587 - (9%)

  Fly    72 FDDILPLIGEFGRYQKLLFICMIPFSFFVAFVYFSQIFLTLIPEQHWCHVPELD----GLDVEAR 132
            |..:|..||:|||:|..|.|.:...:|...|.:|:.:|:.| .|.|.|.|..:.    .|....:
Human     4 FVQVLAEIGDFGRFQIQLLILLCVLNFLSPFYFFAHVFMVL-DEPHHCAVAWVKNHTFNLSAAEQ 67

  Fly   133 LALSIPM-TNGEYNNCYMY-----DVNYTDILAQGKVMADPKWPQVKCRHGWSYNFTEIPYATVA 191
            |.||:|: |.|....|.|:     :.:..|||:.......|      |..||.|....:|  ::.
Human    68 LVLSVPLDTAGHPEPCLMFRPPPANASLQDILSHRFNETQP------CDMGWEYPENRLP--SLK 124

  Fly   192 TEQNWVCDDAALPTYAQSIFFLGAIVGGLLFGWVADRFGRIPALIGTNMMGLLAGVGTAFVSNFW 256
            .|.|.|||...|....||:|..|.:||.|:||.:.||.||...::...::..|.|:.||||.:|.
Human   125 NEFNLVCDRKHLKDTTQSVFMAGLLVGTLMFGPLCDRIGRKATILAQLLLFTLIGLATAFVPSFE 189

  Fly   257 EFAIMRFFV-----GFAFDNCFTMMYILVLEYVGPKYRTFVANMSIAIFFTGAACLLPWIAYFLA 316
            .:..:||.|     |.:|.|     ..|:.|:|||.:||....::...|..| ..:|..:||...
Human   190 LYMALRFAVATAVAGLSFSN-----VTLLTEWVGPSWRTQAVVLAQCNFSLG-QMVLAGLAYGFR 248

  Fly   317 DWKLLAIVTSAPLLLAIFTPFVVPESARWLVSQGKVDKAVGILKKLEKGNGRQVPPQTYQIFTDS 381
            :|:||.|..:||.||..|..:.:|||||||:::|::|:|:.:::|....|.|::.|:...
Human   249 NWRLLQITGTAPGLLLFFYFWALPESARWLLTRGRMDEAIQLIQKAASVNRRKLSPELMN----- 308

  Fly   382 CKRMQEQEAQNGKYSVLDLFKSPRLRRTTLLLIVIWMAISLVFDGHVRNVGSLGLDIFFTFTLAC 446
             :.:.|:...:|  :.||||:.|:||:.||::..:|...||.:.|....||..|||::.|..:..
Human   309 -QLVPEKTGPSG--NALDLFRHPQLRKVTLIIFCVWFVDSLGYYGLSLQVGDFGLDVYLTQLIFG 370

  Fly   447 FTELPADTLLTVILDRFGRRWLACSSMVLSGVFSLLATVVP--VGIYSAALAIMGRFFVNISYNI 509
            ..|:||......::.||||:|....::||.|:..::...:|  :.:....||::|:.....::.|
Human   371 AVEVPARCSSIFMMQRFGRKWSQLGTLVLGGLMCIIIIFIPADLPVVVTMLAVVGKMATAAAFTI 435

  Fly   510 GLQWAAEVLPTVVRAQAVAFIHIMGYVASIIAPFVVYLANISQALPLIILGILGIIGGLLALLLP 574
            ...::||:.||::|...:..:.|...:..|:.|.|:.|.....|||::|.|.|.|:.|||..|||
Human   436 SYVYSAELFPTILRQTGMGLVGIFSRIGGILTPLVILLGEYHAALPMLIYGSLPIVAGLLCTLLP 500

  Fly   575 ETLNHVLPQTLSDGEEFGRGQSIWDFPCLAKQVDDDEDEKRNADVEEVRSQAFVRGTQTGASLNA 639
            ||....|..||.|.|       :...|...|.|..:::           ::|..|.:..|.:..:
Human   501 ETHGQGLKDTLQDLE-------LGPHPRSPKSVPSEKE-----------TEAKGRTSSPGVAFVS 547

  Fly   640 ST 641
            ||
Human   548 ST 549

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG42269	NP_648019.2	2A0119	80..552	CDD:273328	148/488 (30%)
		MFS	206..545	CDD:119392	106/345 (31%)
SLC22A13	NP_004247.2	2A0119	12..510	CDD:273328	164/520 (32%)
		MFS	139..500	CDD:119392	119/374 (32%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	511..551		11/57 (19%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165153615
Domainoid	1	1.000	65	1.000	Domainoid score	I10025
eggNOG	1	0.900	-	-		E33208_3B9N9
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	8	7.850