Protein Alignment CG42269 and SLC22A14

DIOPT Version :9

• Sequence 1: NP_648019.2
• Gene: CG42269 / 38689
• FlyBaseID: FBgn0259164
• Length: 662
• Species: Drosophila melanogaster
• Sequence 2: XP_006713479.2
• Gene: SLC22A14 / 9389
• HGNCID: 8495
• Length: 675
• Species: Homo sapiens
• Alignment Length: 646
• Identity: 161/646 - (24%)
• Similarity: 288/646 - (44%)
• Gaps: 97/646 - (15%)

  Fly    26 GGGADALHRRKSGGGNKELQL---DMGGFKKGQEMAGGNGSDSLPPSM------------DFDDI 75
            |..|.|...:.:|..|.:.:|   |........|:||...|.||...:            .|.::
Human    72 GNFAAAFSAQMAGEENFKEELRSQDASRNLNQHEVAGHPHSWSLEMLLRRLRAVHTKQDDKFANL 136

  Fly    76 LPLIGEFGRY-QKLLFICMIPFSFFVAFVYFSQIFLTLIPEQHWCHV-------PELDGLDVEAR 132
            |..:||||.: |:|:.:..|| |...||..|:..|: ...::.:|:.       |.|...:   :
Human   137 LDAVGEFGTFQQRLVALTFIP-SIMSAFFMFADHFV-FTAQKPYCNTSWILAVGPHLSKAE---Q 196

  Fly   133 LALSIPMT-NGEYNNCYMY---DVNYTDILAQGKVMADPKWPQVKCRHGWSYNFTEIPYATVATE 193
            |.|:||.. ||.:..|:||   ..|...|:..|....|      .|:.||.|  .:....::..|
Human   197 LNLTIPQAPNGSFLTCFMYLPVPWNLDSIIQFGLNDTD------TCQDGWIY--PDAKKRSLINE 253

  Fly   194 QNWVCDDAALPTYAQSIFFLGAIVGGLLFGWVADRFGRIPALIGTNMMGLLA-GVGTAFVSN--- 254
            .:.||........||.:|..|..:|.|:|..:.|:.||.||:: .:::||:. |.||||:::
Human   254 FDLVCGMETKKDTAQIMFMAGLPIGSLIFRLITDKMGRYPAIL-LSLLGLIIFGFGTAFMNSFHL 317

  Fly   255 --FWEFAIMRFFVGFAFDNCFTMMYILVLEYVGPKYRTFVANMSIAIFFTGAACLLPWIAYFLAD 317
              |:.|.|.:..||:|..:     ..|..|::..::|.....:....|..||. ||..|||.|..
Human   318 YLFFRFGISQSVVGYAISS-----ISLATEWLVGEHRAHAIILGHCFFAVGAV-LLTGIAYSLPH 376

  Fly   318 WKLLAIVTSAPLLLAIFTPFVVPESARWLVSQGKVDKAVGILKKLEKGNGRQVPPQTYQIFTDSC 382
            |:||.:|....::..|...:::|||.|||:.:|||.:|..:|......|.:.:|       ::..
Human   377 WQLLFLVGGILVIPFISYIWILPESPRWLMMKGKVKEAKQVLCYAASVNKKTIP-------SNLL 434

  Fly   383 KRMQEQEAQNGKYSVLDLFKSPRLRRTTLLLIVIWMAISLVFDGHVRNVGSLGLDIFFTFTLACF 447
            ..:|....:..:.||||..|:.:|.:.||::..:|..:|..:......:..||:.:.|...:...
Human   435 DELQLPRKKVTRASVLDFCKNRQLCKVTLVMSCVWFTVSYTYFTLSLRMRELGVSVHFRHVVPSI 499

  Fly   448 TELPADTLLTVILDRFGRRWLACSSMVLSGVFSLLATVVPVG---------------IYSAALAI 497
            .|:||......:|.:.||:|....:::.:.::.||...:|.|               :.|..:.:
Human   500 MEVPARLCCIFLLQQIGRKWSLAVTLLQAIIWCLLLLFLPEGEDGLRLKWPRCPATELKSMTILV 564

  Fly   498 --MGRFFVNISYNIGLQWAAEVLPTVVRAQAVAFIHIMGYVASIIAPFVVYLANISQA---LPLI 557
              :..|.:..:..:...:.||:||||:||..:..:.:.....:|::     |..|||.   ||:.
Human   565 LMLREFSLAATVTVFFLYTAELLPTVLRATGLGLVSLASVAGAILS-----LTIISQTPSLLPIF 624

  Fly   558 ILGILGIIGGLLALLLPETLNHVLPQTLSDGEEFGRGQSIWDFPCLAKQVDDDEDEKRNAD 618
            :..:|.|:...|:.|||||.:..|.::|:...:            :..:|.|.:.::.::|
Human   625 LCCVLAIVAFSLSSLLPETRDQPLSESLNHSSQ------------IRNKVKDMKTKETSSD 673

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG42269	NP_648019.2	2A0119	80..552	CDD:273328	129/506 (25%)
		MFS	206..545	CDD:119392	91/361 (25%)
SLC22A14	XP_006713479.2	2A0119	141..650	CDD:273328	142/540 (26%)
		MFS	270..641	CDD:119392	99/389 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165153861
Domainoid	1	1.000	65	1.000	Domainoid score	I10025
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.940