DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG42269 and SLC22A6

DIOPT Version :9

Sequence 1:	NP_648019.2	Gene:	CG42269 / 38689	FlyBaseID:	FBgn0259164	Length:	662	Species:	Drosophila melanogaster
Sequence 2:	NP_004781.2	Gene:	SLC22A6 / 9356	HGNCID:	10970	Length:	563	Species:	Homo sapiens

Alignment Length:	569	Identity:	153/569 - (26%)
Similarity:	262/569 - (46%)	Gaps:	44/569 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    70 MDFDDILPLIGEFGRYQKLLFICMIPFSFFVAFVYFSQIFLTLIPEQHWCHVPELDGLDVEARLA 134
            |.|:|:|..:|..||:|::....::.....:|.....|.|...||..| |..|....|.....|.
Human     1 MAFNDLLQQVGGVGRFQQIQVTLVVLPLLLMASHNTLQNFTAAIPTHH-CRPPADANLSKNGGLE 64

  Fly   135 LSIPM-TNGEYNNCYMYD--------VNYTDILAQGKVMADPKWPQVKCRHGWSYNFTEIPYATV 190
            :.:|. ..|:..:|..:.        :|.|:  |.|....:|      |..||.|:.:..| :|:
Human    65 VWLPRDRQGQPESCLRFTSPQWGLPFLNGTE--ANGTGATEP------CTDGWIYDNSTFP-STI 120

  Fly   191 ATEQNWVCDDAALPTYAQSIFFLGAIVGGLLFGWVADRFGRIPALIGTNMMGLLAGVGTAFVSNF 255
            .||.:.||...||...|||::.:|.::|.::||::|||.||...||...:...::|...||..||
Human   121 VTEWDLVCSHRALRQLAQSLYMVGVLLGAMVFGYLADRLGRRKVLILNYLQTAVSGTCAAFAPNF 185

  Fly   256 WEFAIMRFFVGFAFD----NCFTMMYILVLEYVGPKYRTFVANMSIAIFFTGAACLLPWIAYFLA 316
            ..:...|...|.|..    ||.|    |.:|::....|..|..: |...::....||..:||.:.
Human   186 PIYCAFRLLSGMALAGISLNCMT----LNVEWMPIHTRACVGTL-IGYVYSLGQFLLAGVAYAVP 245

  Fly   317 DWKLLAIVTSAPLLLAIFTPFVVPESARWLVSQGKVDKAVGILKKLEKGNGRQVPPQTYQIFTDS 381
            .|:.|.::.|||........:...|||||..|.|::|..:..|:::.:.||::.......:....
Human   246 HWRHLQLLVSAPFFAFFIYSWFFIESARWHSSSGRLDLTLRALQRVARINGKREEGAKLSMEVLR 310

  Fly   382 CKRMQEQEAQNGKYSVLDLFKSPRLRRTTLLLIVIWMAISLVFDGHVRNVGSLGLDIFFTFTLAC 446
            ....:|.....|:.|.::|.:.|.||...|.|.::|.|.|..:.|.|.::...|:.|:....:..
Human   311 ASLQKELTMGKGQASAMELLRCPTLRHLFLCLSMLWFATSFAYYGLVMDLQGFGVSIYLIQVIFG 375

  Fly   447 FTELPADTLLTVILDRFGRRWLACSSMVLSGVFSLLATVVP--VGIYSAALAIMGRFFVNISYNI 509
            ..:|||..:..::::..|||....::::|:|:..||..|:|  ..|...:||::|:..:..|:|.
Human   376 AVDLPAKLVGFLVINSLGRRPAQMAALLLAGICILLNGVIPQDQSIVRTSLAVLGKGCLAASFNC 440

  Fly   510 GLQWAAEVLPTVVRAQAVAFIHIMGYVASIIAPFVVYLANISQALPLIILGILGIIGGLLALLLP 574
            ...:..|:.||::|...:.....|..|.||::|.|...|.:..::||.|.|.:.:....:.:|||
Human   441 IFLYTGELYPTMIRQTGMGMGSTMARVGSIVSPLVSMTAELYPSMPLFIYGAVPVAASAVTVLLP 505

  Fly   575 ETLNHVLPQTLSDGEEFGRGQSIWD--------FPCLAKQVDDDEDEKR 615
            |||...||.|:.|.|      |.|.        :|...||....::.::
Human   506 ETLGQPLPDTVQDLE------SRWAPTQKEAGIYPRKGKQTRQQQEHQK 548

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42269	NP_648019.2	2A0119	80..552	CDD:273328	129/486 (27%)
CG42269	NP_648019.2	MFS	206..545	CDD:119392	93/344 (27%)
SLC22A6	NP_004781.2	2A0119	11..515	CDD:273328	141/518 (27%)
		MFS	135..505	CDD:119392	100/374 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	525..563		3/24 (13%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165153824
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.950