DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42269 and Slc22a7

DIOPT Version :9

Sequence 1:	NP_648019.2	Gene:	CG42269 / 38689	FlyBaseID:	FBgn0259164	Length:	662	Species:	Drosophila melanogaster
Sequence 2:	NP_445989.2	Gene:	Slc22a7 / 89776	RGDID:	621699	Length:	535	Species:	Rattus norvegicus

Alignment Length:	554	Identity:	159/554 - (28%)
Similarity:	273/554 - (49%)	Gaps:	62/554 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    70 MDFDDILPLIGEFGRYQKLLFICM------IPFSFFVAFVYFSQIFLTLIPEQHWCHVP----EL 124
            |.|:|:|..:|.||.:|....:.|      :|..|.:      .:|:..:|..| |.:|    .|
  Rat     1 MGFEDLLDKVGGFGPFQLRNLVLMALPRMLLPMHFLL------PVFMAAVPAHH-CALPGAPANL 58

  Fly   125 DGLD--VEARLALSIPMTNGEYNNCYMY-------DVNY-TDILAQGKVMADPKWPQVKCRHGWS 179
            ...|  :||.|...   |:|.:::|..:       :|.. |::...|:...:|.  .|.|..||.
  Rat    59 SHQDLWLEAHLPRE---TDGSFSSCLRFAYPQTVPNVTLGTEVSNSGEPEGEPL--TVPCSQGWE 118

  Fly   180 YNFTEIPYATVATEQNWVCDDAALPTYAQSIFFLGAIVGGLLFGWVADRFGRIPALIGTNMMGLL 244
            |:.:|.. :|:|||.:.||....|.....:.||:|.:||.:::|:::|||||...|:...:..|:
  Rat   119 YDRSEFS-STIATEWDLVCQQRGLNKITSTCFFIGVLVGAVVYGYLSDRFGRRRLLLVAYVSSLV 182

  Fly   245 AGVGTAFVSNFWEFAIMRFFVGFAFDNCFTMMYI-LVLEYVGPKYRTFVANMSIAIFFTGAACLL 308
            .|:.:|...|:..|.:.|...|.|... ||::.: |.||::..::|| ||.:...:|::|...||
  Rat   183 LGLMSAASINYIMFVVTRTLTGSALAG-FTIIVLPLELEWLDVEHRT-VAGVISTVFWSGGVLLL 245

  Fly   309 PWIAYFLADWKLLAIVTSAPLLLAIFTPFVVPESARWLVSQGKVDKAVGILKKLEKGNGRQVPPQ 373
            ..:.|.:..|:.|.:..:.|.:..|.:.:.||||||||::||:|::|...|....|.|||.|...
  Rat   246 ALVGYLIRSWRWLLLAATLPCVPGIISIWWVPESARWLLTQGRVEEAKKYLLSCAKLNGRPVGEG 310

  Fly   374 TYQIFTDSCKRMQEQEAQNG---------KYSVLDLFKSPRLRRTTLLLIVIWMAISLVFDGHVR 429
            :.           .|||.|.         :.|.||||::.:||..:|..:::|..::..:.|...
  Rat   311 SL-----------SQEALNNVVTMERALQRPSYLDLFRTSQLRHISLCCMMVWFGVNFSYYGLTL 364

  Fly   430 NVGSLGLDIFFTFTLACFTELPADTLLTVILDRFGRRWLACSSMVLSGVF----SLLATVVPVGI 490
            :|..|||:::.|..|....|||:..::..::.|.||| |..:.|:|....    |||.: :....
  Rat   365 DVSGLGLNVYQTQLLFGAVELPSKIMVYFLVRRLGRR-LTEAGMLLGAALTFGTSLLVS-LETKS 427

  Fly   491 YSAALAIMGRFFVNISYNIGLQWAAEVLPTVVRAQAVAFIHIMGYVASIIAPFVVYLANISQALP 555
            :..||.::|:.|...::.....:.:|:.|||:|...:....:||.:.:.:||....|..:...||
  Rat   428 WITALVVVGKAFSEAAFTTAYLFTSELYPTVLRQTGLGLTALMGRLGASLAPLAALLDGVWLLLP 492

  Fly   556 LIILGILGIIGGLLALLLPETLNHVLPQTLSDGE 589
            .:..|.:.::....|||||||....||:|:.|.|
  Rat   493 KVAYGGIALVAACTALLLPETKKAQLPETIQDVE 526

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42269	NP_648019.2	2A0119	80..552	CDD:273328	140/505 (28%)
CG42269	NP_648019.2	MFS	206..545	CDD:119392	102/352 (29%)
Slc22a7	NP_445989.2	2A0119	11..521	CDD:273328	152/537 (28%)
Slc22a7	NP_445989.2	MFS	144..511	CDD:119392	109/381 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166347374
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9N9
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	1	1.010	-	-		D284622at33208
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.860