DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG42269 and Slc22a8

DIOPT Version :9

Sequence 1:	NP_648019.2	Gene:	CG42269 / 38689	FlyBaseID:	FBgn0259164	Length:	662	Species:	Drosophila melanogaster
Sequence 2:	NP_112622.1	Gene:	Slc22a8 / 83500	RGDID:	632286	Length:	536	Species:	Rattus norvegicus

Alignment Length:	557	Identity:	154/557 - (27%)
Similarity:	248/557 - (44%)	Gaps:	32/557 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    70 MDFDDILPLIGEFGRYQKL-LFICMIPFSFFVAFVYFSQIFLTLIPEQHWCHVPELDGLDVEARL 133
            |.|.:||..:|..|.:|.| :.:..:|. ..:|.....|||....|..| |..|....:.
  Rat     1 MTFSEILDRVGSMGPFQYLHVTLLALPV-LGIANHNLLQIFTATTPVHH-CRPPPNASIG----- 58

  Fly   134 ALSIPM-TNGEYNNCYMYDVNYTDILAQGKVMADPKWPQVKCRHGWSYNFTEIPYATVATEQNWV 197
            ...:|: .||:...|..: |:    |....:..|.:.....|..||.||.|.   .|:..|.:.|
  Rat    59 PWVLPLDPNGKPEKCLRF-VH----LPNASLPNDTQRATEPCLDGWIYNSTR---DTIVIEWDLV 115

  Fly   198 CDDAALPTYAQSIFFLGAIVGGLLFGWVADRFGRIPALIGTNMMGLLAGVGTAFVSNFWEFAIMR 262
            |....|...|||||..|.:|||.:.|.::|||||.|.|..:.:|...:|.|.||..:...:.|.|
  Rat   116 CSSNKLKEMAQSIFMAGILVGGPVIGELSDRFGRKPILTWSYLMLAASGSGAAFSPSLPVYMIFR 180

  Fly   263 FFVGFAFDNCFTMMYILVLEYVGPKYRTFVANMSIAIFFTGAACLLPWIAYFLADWKLLAIVTSA 327
            |..|.:.........||.:|:|....|. :::.||...:|....:|..:||.:..|:.|.:.:||
  Rat   181 FLCGCSISGISLSTVILNVEWVPTSMRA-ISSTSIGYCYTIGQFILSGLAYAIPQWRWLQLTSSA 244

  Fly   328 PLLLAIFTPFVVPESARWLVSQGKVDKAVGILKKLEKGNGRQVPPQTYQIFTDSCKRMQEQEAQN 392
            |..:.....:.||||.||||..||..||:..|:::...||::...:...|........::..:..
  Rat   245 PFFIFSLLSWWVPESIRWLVLSGKYSKALKTLQRVATFNGKKEEGKKLTIEELKFNLQKDITSAK 309

  Fly   393 GKYSVLDLFKSPRLRRTTLLLIVIWMAISLVFDGHVRNVGSLGLDIFFTFTLACFTELPADTLLT 457
            .||.:.|||:...|||.|..|.:.|.:....:......|...|::|:....:....::||..:..
  Rat   310 VKYGLSDLFRVSILRRVTFCLSLAWFSTGFAYYSLAMGVEEFGVNIYILQIIFGGVDIPAKFITI 374

  Fly   458 VILDRFGRRWLACSSMVLSGVFSLLATVVP--VGIYSAALAIMGRFFVNISYNIGLQWAAEVLPT 520
            :.|...|||......::|:|...|....||  :.:...|||:.|:..::.|::....:.:|:.||
  Rat   375 LSLSYLGRRITQSFLLLLAGGAILALIFVPSEMQLLRTALAVFGKGCLSGSFSCLFLYTSELYPT 439

  Fly   521 VVRAQAVAFIHIMGYVASIIAPFVVYLANISQALPLIILGILGIIGGLLALLLPETLNHVLPQTL 585
            |:|...:...::...|.|:|||.|.....:...:|.:|.|...::||..|..|.||||..||:|:
  Rat   440 VLRQTGMGISNVWARVGSMIAPLVKITGELQPFIPNVIFGTTALLGGSAAFFLLETLNRPLPETI 504

  Fly   586 SDGEEFGRGQSIWDFPCLAKQVDDDEDEKRNADVEEV 622
            .|.:.       |.     |||...:.|.......::
  Rat   505 EDIQN-------WH-----KQVQKTKQESEAEKASQI 529

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42269	NP_648019.2	2A0119	80..552	CDD:273328	130/475 (27%)
CG42269	NP_648019.2	MFS	206..545	CDD:119392	98/340 (29%)
Slc22a8	NP_112622.1	2A0119	11..503	CDD:273328	143/507 (28%)
		MFS	124..492	CDD:119392	105/368 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	515..536		1/15 (7%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166347387
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.950