DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42269 and oct2

DIOPT Version :9

Sequence 1:	NP_648019.2	Gene:	CG42269 / 38689	FlyBaseID:	FBgn0259164	Length:	662	Species:	Drosophila melanogaster
Sequence 2:	NP_001107932.1	Gene:	oct2 / 797890	ZFINID:	ZDB-GENE-080204-92	Length:	554	Species:	Danio rerio

Alignment Length:	539	Identity:	167/539 - (30%)
Similarity:	276/539 - (51%)	Gaps:	40/539 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    71 DFDDILPLIGEFGRYQKLLFIC-MIPFSFFVAFVYFSQIFLTLIPEQHWCHVPELD---GLDVEA 131
            :||::|...|:||.|||.:.:. .:|. ..:|||....:||...|: |||....|.   |...|.
Zfish     3 NFDELLQHAGDFGFYQKRISVLGSLPI-LLLAFVLIGVVFLGYTPD-HWCKTASLQEKCGFSEEQ 65

  Fly   132 RLALSIPMT--NGEYNNCYMYDVNYTDILAQGKVMA------DPKWPQVKCRHGWSYNFTEIPYA 188
            ...|::|.|  .|.::.|..:|    |.|..|..::      :.......|..||::|...   .
Zfish    66 VRDLTVPRTGARGAFSKCVKFD----DALRNGSALSCNISIFNNSTHLSACNEGWTFNENR---T 123

  Fly   189 TVATEQNWVCDDAALPTYAQSIFFLGAIVGGLLFGWVADRFGRIPALIGTNMMGLLAGV-GTAFV 252
            |:.||.:.||:|:.|....|.....|..:|.|:.|::||||||....| .::.||  || ||..:
Zfish   124 TIVTEFSLVCEDSWLADLNQVSLAGGFFIGALVTGYLADRFGRKSCFI-ASIFGL--GVSGTCII 185

  Fly   253 SNFWEFAIMRFF---VGFAFDNCFTMMYILVLEYVGPKYRTFVANMSIAIFFTGAACLLPWIAYF 314
            .:.: :.::.||   .||.....:|..|:|::|:.|...|.||:.|| ..|::....|||.:||:
Zfish   186 FSPY-YPLLLFFRCLQGFFAKGAWTATYVLIIEFFGSNNRKFVSVMS-RTFYSLGLVLLPALAYY 248

  Fly   315 LADWKLLAIVTSAPLLLAIFTPFVVPESARWLVSQGKVDKAVGILKKLEKGNGRQVPPQTYQIFT 379
            :..|:.|.:..:.|..:.:...:|:|||.|||:||.|..:|:.|:|.:.|.|.|.:|...:::
Zfish   249 IPSWRNLQLAMTLPTFIFLIYHWVIPESPRWLLSQRKTKEALSIVKSIAKCNKRSLPEDFHEM-- 311

  Fly   380 DSCKRMQEQEAQNGKYSVLDLFKSPRLRRTTLLLIVIWMAISLVFDGHVRNVGSLGLDIFFTFTL 444
               ..:.|::.:..:.|..||||:|::|:.|.:||..|...::||.|.|..:|..|.::|..|.:
Zfish   312 ---DLLIEKQEEIMRPSYKDLFKTPKMRKHTFILIYAWFTGAVVFQGLVLRLGITGDNVFLDFLI 373

  Fly   445 ACFTELPADTLLTVILDRFGRRWLACSSMVLSGVFSLLATVVPVGI--YSAALAIMGRFFVNISY 507
            :...|||...:...::||.|||.|..:...:.|...|....:...|  ....:||:||..|.|.
Zfish   374 SAVVELPTGLIFYFLVDRIGRRPLMATVNFIGGAACLAVPFISPNISWLRRTIAIVGRLAVAIG- 437

  Fly   508 NIGLQWA-AEVLPTVVRAQAVAFIHIMGYVASIIAPFVVY-LANISQALPLIILGILGIIGGLLA 570
            |..:.:| .|:.||.:|...|:.......:.:::|||::| ||:|.|.|||::.|::.::...|.
Zfish   438 NETVNFANTELYPTPLRNLGVSVCSSASDIGAVVAPFILYRLASIWQELPLLVYGVMSVLYSGLV 502

  Fly   571 LLLPETLNHVLPQTLSDGE 589
            :||||.....||:|:.|.|
Zfish   503 MLLPEMKGVDLPETVDDVE 521

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42269	NP_648019.2	2A0119	80..552	CDD:273328	149/491 (30%)
CG42269	NP_648019.2	MFS	206..545	CDD:119392	106/345 (31%)
oct2	NP_001107932.1	2A0119	12..516	CDD:273328	161/523 (31%)
oct2	NP_001107932.1	MFS	123..506	CDD:119392	124/393 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170588940
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9N9
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	9	8.850