DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42269 and slc22a15.2

DIOPT Version :9

Sequence 1:	NP_648019.2	Gene:	CG42269 / 38689	FlyBaseID:	FBgn0259164	Length:	662	Species:	Drosophila melanogaster
Sequence 2:	NP_001039179.1	Gene:	slc22a15.2 / 734018	XenbaseID:	XB-GENE-5824718	Length:	487	Species:	Xenopus tropicalis

Alignment Length:	535	Identity:	145/535 - (27%)
Similarity:	242/535 - (45%)	Gaps:	84/535 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    70 MDFDDILPLIGEFGRYQKLLFICMIPFSFFVAFVYFSQIFLTLIPEQHWCH---------VPE-- 123
            ||.|:....|||||..||.|          .||:...|:::.       |.         |||
Frog     1 MDLDEAFLYIGEFGCCQKRL----------TAFLTLLQVYVA-------CQSMLIVLVGAVPEYL 48

  Fly   124 LDGLDVEARLALSIPMTNGEYNNCYMYDVNYTDILAQGKVMADPKWPQVKCRHGWSYNFTEIPYA 188
            :|..|:.|        :..||.. :::|.|                           |||
Frog    49 IDNEDISA--------SKEEYTK-HLHDTN---------------------------NFT----- 72

  Fly   189 TVATEQNWVCDDAALPTYAQSIFFLGAIVGGLLFGWVADRFGRIPALIGTNMMGLLAGVGTAFVS 253
            ::.:|.:.:.::|.....|.|:||.|.::|.:|||.::|:.||.|..:......:..|..||...
Frog    73 SIVSEWHLIKNEAYKVNLASSLFFAGLLIGNILFGPLSDKLGRRPVYLSGLFFDITFGYCTALAP 137

  Fly   254 NFWEFAIMRFFVGFAFDNCFTMMYILVLEYVGPKYRTFVANMSIAIFFTGAACLLPWIAYFLADW 318
            ::..||:.|||||........:.::|..||||..|.....:::..||..|.| ....:.:::.:|
Frog   138 SYEVFAVSRFFVGIMNGGMALVSFVLTQEYVGKSYWALTGSLTNLIFAVGIA-FYALLGFYIRNW 201

  Fly   319 KLLAIVTSAPLLLAIFTPFVVPESARWLVSQGKVDKAVGILKKLEKGNGRQVPPQTYQIFTDSCK 383
            :.||.|.::|.:......|::|||.|||.|.|...:|.|:|:.:..|||.:.|    .:...||.
Frog   202 RTLAFVANSPGIFFFLLSFLLPESPRWLYSHGYTTEAEGVLQSMAVGNGVERP----VVKLKSCP 262

  Fly   384 RMQEQEAQNGKYSVLDLFKSPRLRRTTLLLIVIWMAISLVFDGHVRNVGSLGLDIFFTFTLACFT 448
            ....:.|    :||.||.|...||..|:||:.||...|||:.|...|.|.|..:::....|....
Frog   263 GTSSKSA----HSVFDLVKYGVLRWRTILLMYIWYVCSLVYYGLTLNAGELKGNLYLNVALYGLV 323

  Fly   449 ELPADTLLTVILDR--FGRRWLACSSMVLSGVFSLLATVVPVG----IYSAALAIMGRFFVNISY 507
            |:||..|....:::  .|||......:..:|...:....:|..    :....||:.|:..|:.::
Frog   324 EVPAFPLCLYFIEKSWSGRRKATAGFLGFAGFACIFTIFLPETNGDLLNPTVLALFGKLSVSAAF 388

  Fly   508 NIGLQWAAEVLPTVVRAQAVAFIHIMGYVASIIAPFVVYLANISQALPLIILGILGIIGGLLALL 572
            |:...:.:|:.|||||...:....:......|::||:..:.:::.::|.:..||.||..|:|:||
Frog   389 NVVYIYTSELYPTVVRNAGLGVCAMACRFGGILSPFIPTMKSLNPSMPFVAFGISGISAGILSLL 453

  Fly   573 LPETLNHVLPQTLSD 587
            ||||.|..:.:::.|
Frog   454 LPETRNKPIAESIED 468

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42269	NP_648019.2	2A0119	80..552	CDD:273328	126/488 (26%)
CG42269	NP_648019.2	MFS	206..545	CDD:119392	100/344 (29%)
slc22a15.2	NP_001039179.1	MFS	48..455	CDD:391944	121/456 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.920