DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42269 and Slc22a23

DIOPT Version :9

Sequence 1:	NP_648019.2	Gene:	CG42269 / 38689	FlyBaseID:	FBgn0259164	Length:	662	Species:	Drosophila melanogaster
Sequence 2:	NP_001028339.1	Gene:	Slc22a23 / 73102	MGIID:	1920352	Length:	689	Species:	Mus musculus

Alignment Length:	736	Identity:	161/736 - (21%)
Similarity:	271/736 - (36%)	Gaps:	177/736 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 GGGGGADALHRRKSGG---GNKELQLDMGGFKKGQEMAGGNGSD-------SLPPS--------- 69
            |.|.|.......::|.   |:......:||       ..|:||.       :|.||
Mouse    11 GSGAGRQPAPAEENGSLPPGDAAASAPLGG-------RAGSGSSAEIQPLPALHPSGGPHSSCCA 68

  Fly    70 ---------MDFD-DILPLIGEF-GRYQK-LLFICMIPFSFFVAFVYFSQIFLTLIPEQHWCH-- 120
                     :|:| .:||.:|.. |.||| |:.:..|| :.|:.|..||..||...|: .||.
Mouse    69 ATAAPSLLLLDYDGSVLPFLGGLGGGYQKTLVVLTWIP-ALFIGFSQFSDSFLLDQPD-FWCRGA 131

  Fly   121 --VPELDGLDVEARL------------------------------ALSIPMTNGEYNNCYMYDVN 153
              ..||.|..|..|.                              ...:|...|:.||    |.|
Mouse   132 GKGTELAGATVTGRWGDMGNWTSPSATPFSTASWGTTSNRSNSSDTPPLPSPPGKGNN----DSN 192

  Fly   154 YTDILAQGKVMADPKWPQVKCRHGWSYNFTEIPYATVATEQNWVCDDAALPTYAQSIFFLGAIVG 218
                              ..| |.|.|.........|.::.:.|||:......|:....:|.|.|
Mouse   193 ------------------CDC-HAWDYGIRTGLIQNVVSKWDLVCDNTWKVHIAKFSLLVGLIFG 238

  Fly   219 GLLFGWVADRFGRIPALIGTNMMGLLAGVGTAFVSNFWEFAIMRFFVGFAFDNCFTMMYILVLEY 283
            .|:.|.:||..||.|.|:.:.:..|:.|:..|...|...|:.:|||.||........:|.|.:|.
Mouse   239 YLITGCIADWVGRRPVLLFSTIFILIFGLTVALSVNVTMFSTLRFFEGFCLAGIILTLYALRIEL 303

  Fly   284 VGPKYRTFVANMSIAIFFTGAACLLPWIAYFLADWKLLAIVTSAPLLLAIFTPFVVPESARWLVS 348
            ..|..| |:..|..:........|:|.:|....||::|..:...|.||.:....:.|||.|||::
Mouse   304 CPPGKR-FIITMVASFVAMAGQFLMPGLAALCRDWQVLQALIICPFLLMLLYWSIFPESLRWLMA 367

  Fly   349 QGKVDKAVGILKKLEKGNGRQVPPQTYQIFTDSCKRMQEQEAQNGKYSVLDLFKSPRLRRTTLLL 413
            ..:.:.|..::..|.:.|  .|.|:     :|....|.|.|.:          .|.|.::..::.
Mouse   368 TQQFESAKKLILYLTQKN--CVSPE-----SDIKGVMPELEKE----------LSRRPKKVCIVK 415

  Fly   414 IV----IWMAISLVFDGHVRNVG--------SLG-------LDIFFT--FTLACFTELPADTLLT 457
            :|    :|..|.::....:...|        .:|       |:.|:.  :|:|... |.:...:.
Mouse   416 VVGTRNLWKNIVVLCVNSLTGYGIHHCFARSMMGHEVKVPLLENFYADYYTMASIA-LASCLAMC 479

  Fly   458 VILDRFGRRWLACSSMVLSGVFSLLATVVPVGI------------------------------YS 492
            :::...|||    ..::|..:.:.||:::.:|:                              :|
Mouse   480 LVVKFLGRR----GGLLLFMILTALASLLQLGLLNLIGKYSQHPDSELQLKLAVGMSDSVKDKFS 540

  Fly   493 AALAIMGRFFVNISYNIGLQWAAEVLPTVVRAQAVAFIHIMGYVASIIAPFVVYLANISQALPLI 557
            .|.:|:|.|..:...::.:.:.||:.|||:|...:..:........:.||.:.........|..|
Mouse   541 IAFSIVGMFASHAVGSLSVFFCAEITPTVIRCGGLGLVLASAGFGMLTAPIIELHNQKGYFLHHI 605

  Fly   558 ILGILGIIGGLLALLLPETLNHVLPQTLSDGEEFGRGQSIWDFPCLAKQVDDDEDEKRNADVEEV 622
            |.....:|..:..|||||:.|..||:.:::||.:.|.      |.|..:..:......||::::.
Mouse   606 IFACCTLICIICILLLPESRNQNLPENIANGEHYTRQ------PLLPHKKGEQPLLLTNAELKDY 664

  Fly   623 RSQAFVRGTQTGASLNASTGG 643
            .....|.....|....|:..|
Mouse   665 SGLHDVAAVGDGLPEGATANG 685

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42269	NP_648019.2	2A0119	80..552	CDD:273328	121/558 (22%)
CG42269	NP_648019.2	MFS	206..545	CDD:119392	85/389 (22%)
Slc22a23	NP_001028339.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..55		10/50 (20%)
		2A0119	98..631	CDD:273328	127/580 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	162..188		2/25 (8%)
		MFS	230..>359	CDD:119392	37/129 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167843359
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.030