Protein Alignment CG42269 and SLC22A4

DIOPT Version :9

• Sequence 1: NP_648019.2
• Gene: CG42269 / 38689
• FlyBaseID: FBgn0259164
• Length: 662
• Species: Drosophila melanogaster
• Sequence 2: NP_003050.2
• Gene: SLC22A4 / 6583
• HGNCID: 10968
• Length: 551
• Species: Homo sapiens
• Alignment Length: 562
• Identity: 162/562 - (28%)
• Similarity: 281/562 - (50%)
• Gaps: 37/562 - (6%)

  Fly    71 DFDDILPLIGEFGRYQKLLFICMIPFSFFVAFVYFSQIFLTLIPEQHWCHVPELDGLDVEARLAL 135
            |:|:::..:||:|.:|:|:|..:........|...|.:||...|| |.|.||:...|. .|....
Human     3 DYDEVIAFLGEWGPFQRLIFFLLSASIIPNGFNGMSVVFLAGTPE-HRCRVPDAANLS-SAWRNN 65

  Fly   136 SIP--MTNGEY--NNCYMYDV----NYTDI-LAQGKVMADPKWPQVKCRHGWSYNFTEIPYATVA 191
            |:|  :.:|..  ::|..|.:    |::.: |..|:.:...:..|..|..||.:: .::..:||.
Human    66 SVPLRLRDGREVPHSCSRYRLATIANFSALGLEPGRDVDLGQLEQESCLDGWEFS-QDVYLSTVV 129

  Fly   192 TEQNWVCDDAALPTYAQSIFFLGAIVGGLLFGWVADRFGRIPALIGTNMMGLLAGVGTAFVSNF- 255
            ||.|.||:|........|:||:|.::|..:.|.::|||||...|..|    :....|.:|:..|
Human   130 TEWNLVCEDNWKVPLTTSLFFVGVLLGSFVSGQLSDRFGRKNVLFAT----MAVQTGFSFLQIFS 190

  Fly   256 --WE-FAIMRFFVGFAFDNCFTMMYILVLEYVGPKYRTFVANMSIAIFFTGAACLLPWIAYFLAD 317
              || |.::...||....:.:.:.:||..|.:|...|...:.:.:..||.....|||..|||:.|
Human   191 ISWEMFTVLFVIVGMGQISNYVVAFILGTEILGKSVRIIFSTLGVCTFFAVGYMLLPLFAYFIRD 255

  Fly   318 WKLLAIVTSAPLLLAIFTPFVVPESARWLVSQGKVDKAVGILKKLEKGNGRQVPPQTYQIFTDSC 382
            |::|.:..:.|.:|.:...:.:|||.|||:||.:..:|..|::|..|.|...||    .:..||.
Human   256 WRMLLLALTVPGVLCVPLWWFIPESPRWLISQRRFREAEDIIQKAAKMNNIAVP----AVIFDSV 316

  Fly   383 KRMQEQEAQNGKYSVLDLFKSPRLRRTTLLLIVIWMAISLVFDGHVRNVGSLGLDIFFTFTLACF 447
            :.:...:.|  |..:||||::..:...|::.:::||..|:.:.....:..:|..|.:....|:..
Human   317 EELNPLKQQ--KAFILDLFRTRNIAIMTIMSLLLWMLTSVGYFALSLDAPNLHGDAYLNCFLSAL 379

  Fly   448 TELPADTLLTVILDRFGRRWLACSSMVLSGVFSLLATVVPVGIY--SAALAIMGRFFVNISYNIG 510
            .|:||.....::|....||::..:.:...|...|...:|||..|  |..|.::|:|.:..::::.
Human   380 IEIPAYITAWLLLRTLPRRYIIAAVLFWGGGVLLFIQLVPVDYYFLSIGLVMLGKFGITSAFSML 444

  Fly   511 LQWAAEVLPTVVRAQAVAFIHIMGYVASIIAPFVVYLANISQALPLIILGILGIIGGLLALLLPE 575
            ..:.||:.||:||..||........|.|||||:.|||...::.||.|::|.|.::.|:|.|..||
Human   445 YVFTAELYPTLVRNMAVGVTSTASRVGSIIAPYFVYLGAYNRMLPYIVMGSLTVLIGILTLFFPE 509

  Fly   576 TLNHVLPQTLSDGEE---FGRGQSIWDFPCLAKQVDDDEDEK 614
            :|...||:||...::   |..|:...|      .::.:|:.|
Human   510 SLGMTLPETLEQMQKVKWFRSGKKTRD------SMETEENPK 545

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG42269	NP_648019.2	2A0119	80..552	CDD:273328	140/486 (29%)
		MFS	206..545	CDD:119392	99/344 (29%)
SLC22A4	NP_003050.2	2A0119	12..518	CDD:273328	153/518 (30%)
		MFS	123..508	CDD:119392	118/394 (30%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165153715
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9N9
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.850