Protein Alignment CG42269 and SLC22A2

DIOPT Version :9

• Sequence 1: NP_648019.2
• Gene: CG42269 / 38689
• FlyBaseID: FBgn0259164
• Length: 662
• Species: Drosophila melanogaster
• Sequence 2: NP_003049.2
• Gene: SLC22A2 / 6582
• HGNCID: 10966
• Length: 555
• Species: Homo sapiens
• Alignment Length: 547
• Identity: 164/547 - (29%)
• Similarity: 268/547 - (48%)
• Gaps: 44/547 - (8%)

  Fly    73 DDILPLIGEFGRYQKLLFICMIPFSFFVAFVYFSQIFLTLIPEQHWCHVPELDGLDV-------- 129
            ||:|...|||..:||.:|..:...|...|.:|...:||...|: |.|..|.:..|.:
Human     6 DDVLEHGGEFHFFQKQMFFLLALLSATFAPIYVGIVFLGFTPD-HRCRSPGVAELSLRCGWSPAE 69

  Fly   130 EARLALSIPMTNGEYN--NCYMYDVNYTDILAQGKVMADP---------KWPQVKCRHGWSYNFT 183
            |....:..|...||.:  .|..|:|::......   ..||         :.|...||.||.|
Human    70 ELNYTVPGPGPAGEASPRQCRRYEVDWNQSTFD---CVDPLASLDTNRSRLPLGPCRDGWVY--- 128

  Fly   184 EIPYATVATEQNWVCDDAALPTYAQSIFFLGAIVGGLLFGWVADRFGRIPALIGTNMMGLLAGVG 248
            |.|.:::.||.|.||.::.:....||...:|..:|.:..|::||||||...|:.|.::...|||.
Human   129 ETPGSSIVTEFNLVCANSWMLDLFQSSVNVGFFIGSMSIGYIADRFGRKLCLLTTVLINAAAGVL 193

  Fly   249 TAFVSNFWEFAIMRFFVGFAFDNCFTMMYILVLEYVGPKYRTFVANMSIAIF----FTGAACLLP 309
            .|....:....|.|...|......:.:.|||:.|:||.:||     .::.||    :|....:|.
Human   194 MAISPTYTWMLIFRLIQGLVSKAGWLIGYILITEFVGRRYR-----RTVGIFYQVAYTVGLLVLA 253

  Fly   310 WIAYFLADWKLLAIVTSAPLLLAIFTPFVVPESARWLVSQGKVDKAVGILKKLEKGNGRQVPPQT 374
            .:||.|..|:.|....|.|....:...:.:|||.|||:||.|..:|:.|:|.:.|.||:.:|...
Human   254 GVAYALPHWRWLQFTVSLPNFFFLLYYWCIPESPRWLISQNKNAEAMRIIKHIAKKNGKSLPASL 318

  Fly   375 YQIFTDSCKRMQEQEAQNGKYSVLDLFKSPRLRRTTLLLIVIWMAISLVFDGHVRNVGSLGLDIF 439
            .::      |::|:..:....|.|||.::|::|:.|::|:..|...|:::.|.:.::|..|.:|:
Human   319 QRL------RLEEETGKKLNPSFLDLVRTPQIRKHTMILMYNWFTSSVLYQGLIMHMGLAGDNIY 377

  Fly   440 FTFTLACFTELPADTLLTVILDRFGRRWLACSSMVLSGVFSLLATVVPVGI--YSAALAIMGRFF 502
            ..|..:...|.||..::.:.:||.|||:...:|.:::|...|.:..:|..:  ....::.:||..
Human   378 LDFFYSALVEFPAAFMIILTIDRIGRRYPWAASNMVAGAACLASVFIPGDLQWLKIIISCLGRMG 442

  Fly   503 VNISYNIGLQWAAEVLPTVVRAQAVAFIHIMGYVASIIAPFVVY-LANISQALPLIILGILGIIG 566
            :.::|.|.....||:.||.:|...|.....|..:..||.||:|| |.||...|||::.|:||::.
Human   443 ITMAYEIVCLVNAELYPTFIRNLGVHICSSMCDIGGIITPFLVYRLTNIWLELPLMVFGVLGLVA 507

  Fly   567 GLLALLLPETLNHVLPQTLSDGEEFGR 593
            |.|.||||||....||:|:.:.|...|
Human   508 GGLVLLLPETKGKALPETIEEAENMQR 534

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG42269	NP_648019.2	2A0119	80..552	CDD:273328	142/497 (29%)
		MFS	206..545	CDD:119392	99/344 (29%)
SLC22A2	NP_003049.2	2A0119	13..525	CDD:273328	158/529 (30%)
		MFS	124..492	CDD:119392	113/381 (30%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165153657
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9N9
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	8	7.850