Protein Alignment CG42269 and SLC22A3

DIOPT Version :9

• Sequence 1: NP_648019.2
• Gene: CG42269 / 38689
• FlyBaseID: FBgn0259164
• Length: 662
• Species: Drosophila melanogaster
• Sequence 2: NP_068812.1
• Gene: SLC22A3 / 6581
• HGNCID: 10967
• Length: 556
• Species: Homo sapiens
• Alignment Length: 560
• Identity: 181/560 - (32%)
• Similarity: 287/560 - (51%)
• Gaps: 52/560 - (9%)

  Fly    68 PSMDFDDILPLIGEFGRYQKLLF--ICMIPFSFFVAFVYFSQIFLTLIPEQHWCHVP------EL 124
            ||  ||:.|..:|||||:|:.:|  :|:...:|  ||::...:||...|:.:||..|      |.
Human     2 PS--FDEALQRVGEFGRFQRRVFLLLCLTGVTF--AFLFVGVVFLGTQPDHYWCRGPSAAALAER 62

  Fly   125 DGLDVEARLALSIPMTNG-----EYNNCYMY-------DVNYTDILAQGKVMADP-------KWP 170
            .|...|.....:.|.:.|     ....|..|       ..:.|..|:    .|||       ..|
Human    63 CGWSPEEEWNRTAPASRGPEPPERRGRCQRYLLEAANDSASATSALS----CADPLAAFPNRSAP 123

  Fly   171 QVKCRHGWSYNFTEIPYATVATEQNWVCDDAALPTYAQSIFFLGAIVGGLLFGWVADRFGRIPAL 235
            .|.||.||.|   ...::|:.:|.:.||.:|.:....|:|..||.:.|....|:.|||:|||...
Human   124 LVPCRGGWRY---AQAHSTIVSEFDLVCVNAWMLDLTQAILNLGFLTGAFTLGYAADRYGRIVIY 185

  Fly   236 IGTNMMGL-LAGVGTAFVSNFWEFAIMRFFVGFAFDNCFTMMYILVLEYVGPKYRTFVANMSIAI 299
            : .:.:|: :.||..||..||..|.|.||..|......:...|::|.|.||.|.|..| .:.|.:
Human   186 L-LSCLGVGVTGVVVAFAPNFPVFVIFRFLQGVFGKGTWMTCYVIVTEIVGSKQRRIV-GIVIQM 248

  Fly   300 FFTGAACLLPWIAYFLADWKLLAIVTSAPLLLAIFTPFVVPESARWLVSQGKVDKAVGILKKLEK 364
            |||....:||.||||:.:|:.:.:..:.|..|.:...:|||||.|||:::.|.|||:.||:::.|
Human   249 FFTLGIIILPGIAYFIPNWQGIQLAITLPSFLFLLYYWVVPESPRWLITRKKGDKALQILRRIAK 313

  Fly   365 GNGRQVPPQTYQIFTDSCKRMQEQEAQNGKYSVLDLFKSPRLRRTTLLLIVIWMAISLVFDGHVR 429
            .||:.:.....:|      .:.::|..|.  |.|||.::|::|:.||:|:..|...::|:.|.|.
Human   314 CNGKYLSSNYSEI------TVTDEEVSNP--SFLDLVRTPQMRKCTLILMFAWFTSAVVYQGLVM 370

  Fly   430 NVGSLGLDIFFTFTLACFTELPADTLLTVILDRFGRRWLACSSMVLSGVFSLLATVVPVGI--YS 492
            .:|.:|.:::..|.::...|||...|:.:.::|.|||....:|.:::||..|:...:|.||  ..
Human   371 RLGIIGGNLYIDFFISGVVELPGALLILLTIERLGRRLPFAASNIVAGVACLVTAFLPEGIAWLR 435

  Fly   493 AALAIMGRFFVNISYNIGLQWAAEVLPTVVRAQAVAFIHIMGYVASIIAPFVVY-LANISQALPL 556
            ..:|.:||..:.:::.|.....:|:.||.:|...|:....:.....|||||::: ||.:...|||
Human   436 TTVATLGRLGITMAFEIVYLVNSELYPTTLRNFGVSLCSGLCDFGGIIAPFLLFRLAAVWLELPL 500

  Fly   557 IILGILGIIGGLLALLLPETLNHVLPQTLSDGEEFGRGQS 596
            ||.|||..|.|.|.:|||||....||:|:.|.|:.|...|
Human   501 IIFGILASICGGLVMLLPETKGIALPETVDDVEKLGSPHS 540

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG42269	NP_648019.2	2A0119	80..552	CDD:273328	153/502 (30%)
		MFS	206..545	CDD:119392	110/341 (32%)
SLC22A3	NP_068812.1	2A0119	12..528	CDD:273328	171/534 (32%)
		MFS	149..518	CDD:119392	125/378 (33%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165153849
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9N9
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	8	7.850