DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42269 and Slc22a23

DIOPT Version :9

Sequence 1:	NP_648019.2	Gene:	CG42269 / 38689	FlyBaseID:	FBgn0259164	Length:	662	Species:	Drosophila melanogaster
Sequence 2:	NP_072146.1	Gene:	Slc22a23 / 64559	RGDID:	620302	Length:	689	Species:	Rattus norvegicus

Alignment Length:	736	Identity:	165/736 - (22%)
Similarity:	273/736 - (37%)	Gaps:	177/736 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 GGGGGADALHRRKSGG---GNKELQLDMGGFKKGQEMAGGNGSDSLPP----------------- 68
            |.|.|.......::|.   |:......:||      .||..||..:.|
  Rat    11 GSGAGRQPAPAEENGSLPPGDAAASAPLGG------RAGSGGSAEIQPLPALHPSGGPHSSCCAA 69

  Fly    69 -------SMDFD-DILPLIGEF-GRYQK-LLFICMIPFSFFVAFVYFSQIFLTLIPEQHWCH--- 120
                   .:|:| .:||.:|.. |.||| |:.:..|| :.|:.|..||..|| |.....|||
  Rat    70 AAAPSLLLLDYDGSVLPFLGGLGGGYQKTLVVLTWIP-ALFIGFSQFSDSFL-LDQPNFWCHGAG 132

  Fly   121 -VPELDGLDVEARL------------------------------ALSIPMTNGEYNNCYMYDVNY 154
             ..||.|..|..|.                              ...:|...|:.||    |.|
  Rat   133 KGTELAGATVTGRWGDMGNWTSPSATPFSTASWGTTSNRSNSSDTPPLPSPPGKGNN----DSN- 192

  Fly   155 TDILAQGKVMADPKWPQVKCRHGWSYNFTEIPYATVATEQNWVCDDAALPTYAQSIFFLGAIVGG 219
                             .:| |.|.|.........|.::.:.|||:|.....|:....:|.|.|.
  Rat   193 -----------------CEC-HAWDYGIRTGLVQNVVSKWDLVCDNAWKVHVAKFSLLVGLIFGY 239

  Fly   220 LLFGWVADRFGRIPALIGTNMMGLLAGVGTAFVSNFWEFAIMRFFVGFAFDNCFTMMYILVLEYV 284
            |:.|.:||..||.|.|:.:.:..|:.|:..|...|...|:.:|||.||........:|.|.:|..
  Rat   240 LITGCIADWVGRRPVLLFSVIFILIFGLTVALSVNVTMFSTLRFFEGFCLAGIILTLYALRIELC 304

  Fly   285 GPKYRTFVANMSIAIFFTGAACLLPWIAYFLADWKLLAIVTSAPLLLAIFTPFVVPESARWLVSQ 349
            .|..| |:..|..:........|:|.:|....||::|..:...|.||.:....:.|||.|||::.
  Rat   305 PPGKR-FIITMVASFVAMAGQFLMPGLAALCRDWQVLQALIICPFLLMLLYWSIFPESLRWLMAT 368

  Fly   350 GKVDKAVGILKKLEKGNGRQVPPQTYQIFTDSCKRMQEQEAQNGKYSVLDLFKSPRLRRTTLLLI 414
            .:.:.|..::..|.:.|  .|.|:     :|....|.|.|.:          .|.|.::..::.:
  Rat   369 QQFESAKKLILYLTQKN--CVSPE-----SDIKGVMPELEKE----------LSRRPKKVCIVKV 416

  Fly   415 V----IWMAISLVFDGHVRNVG--------SLG-------LDIFFT--FTLACFTELPADTLLTV 458
            |    :|..|.::....:...|        .:|       |:.|:.  :|:|...  .|..|...
  Rat   417 VGTRNLWKNIVVLCVNSLTGYGIHHCFARSMMGHEVKVPLLENFYADYYTMASIA--LASCLAMC 479

  Fly   459 ILDRF-GRRWLACSSMVLSGVFSLLATVVPVGI------------------------------YS 492
            ::.|| |||    ..::|..:.:.||:::.:|:                              :|
  Rat   480 LVVRFLGRR----GGLLLFMILTALASLLQLGLLNLIGKYSQHPDSELQLKLAVGMSDSVKDKFS 540

  Fly   493 AALAIMGRFFVNISYNIGLQWAAEVLPTVVRAQAVAFIHIMGYVASIIAPFVVYLANISQALPLI 557
            .|.:|:|.|..:...::.:.:.||:.|||:|...:..:........:.||.:.........|..|
  Rat   541 IAFSIVGMFASHAVGSLSVFFCAEITPTVIRCGGLGLVLASAGFGMLTAPIIELHNQKGYFLHHI 605

  Fly   558 ILGILGIIGGLLALLLPETLNHVLPQTLSDGEEFGRGQSIWDFPCLAKQVDDDEDEKRNADVEEV 622
            |.....:|..:..|||||:.:..||:.:::||.:.|.      |.|:.:..:......||::::.
  Rat   606 IFACCTLICIICILLLPESRDQNLPENIANGEHYTRQ------PLLSHKKGEQPLLLTNAELKDY 664

  Fly   623 RSQAFVRGTQTGASLNASTGG 643
            .....|.....|.|..|:..|
  Rat   665 SGLHDVAAVGDGLSEGATANG 685

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42269	NP_648019.2	2A0119	80..552	CDD:273328	126/559 (23%)
CG42269	NP_648019.2	MFS	206..545	CDD:119392	88/390 (23%)
Slc22a23	NP_072146.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..55		12/49 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	162..188		2/25 (8%)
		MFS_SLC22A23	187..608	CDD:341002	104/467 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166346873
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.030