DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CG42269 and slc22a31

DIOPT Version :9

Sequence 1:NP_648019.2 Gene:CG42269 / 38689 FlyBaseID:FBgn0259164 Length:662 Species:Drosophila melanogaster
Sequence 2:XP_699154.4 Gene:slc22a31 / 570565 ZFINID:ZDB-GENE-130530-858 Length:610 Species:Danio rerio


Alignment Length:563 Identity:152/563 - (26%)
Similarity:246/563 - (43%) Gaps:73/563 - (12%)


- Green bases have known domain annotations that are detailed below.


  Fly    70 MDFD-DILPLIGEFGRYQKLLFICMIPFSFF----VAFVYFSQIFLTLIPEQHWCHVPE------ 123
            |::: .|.|.:|.:|||.:::.:    ||:|    |:...|:.:|.||:||.:.|...:      
Zfish     1 MEYETKIYPQVGGYGRYNRIITL----FSWFPNFAVSLNLFTDVFFTLVPESYHCKPDQALLPPS 61

  Fly   124 --LDGLDVEARLALSIPMTNGE-YNNC--YMYDV---NYTDILAQGKVMADPKWPQVKCRHGWSY 180
              |..|..:|.|.|::|...|. :::|  |.|.|   ||||         |.:...|.|..||.:
Zfish    62 ALLSNLSRQAYLNLTVPWLKGSGFSHCELYKYPVNVSNYTD---------DVERDVVSCTGGWEF 117

  Fly   181 NFTEIPYATVATEQNWVCDDAALPTYAQSIFFLGAIVGGLLFGWVADRFGRIPALIGTNMMGLLA 245
            :........:.||.|.||||..........|..|..:|.:|.|.:.|..||..||:.:.::..|.
Zfish   118 SKPAGLQNNLVTEWNLVCDDYWKIPLQHICFMTGWTLGYILLGTLCDWLGRRRALLLSVVLSGLL 182

  Fly   246 GVGTAFVSNFWEFAIMRFFVGFAFDNCFTMMYILVLEYVGPKYRTFVANMS--IAIFFTGAACLL 308
            |:.....::...|..:|...|......|...||..||:..|.:|..|:.:|  .|:|   |..||
Zfish   183 GIMACISNSPSAFPFLRLCQGSTLAGVFLSSYIARLEWCDPSHRLMVSMVSGFFAVF---AELLL 244

  Fly   309 PWIAYFLADWKLLAIVTSAPLLLAI---FTPFVVPESARWLVSQGKVDKAVGILKKLEKGNGRQV 370
            |.:|....||.:|..|.:.||||.:   ....|.|||.|||::..::.:|...|:.....||..|
Zfish   245 PGLAVLCRDWPVLQAVATLPLLLLLSYWCCASVFPESPRWLLATAQIPQAKECLQSFSARNGMCV 309

  Fly   371 PPQTY--QIFTDSCKRMQEQEAQNGKYSVLDLFKSPRLRRTTLLL---IVIWMAISLVFDGHVRN 430
            ..:.|  :...........::.|...:.|.:|..:..:.:..|:|   :.|...|...|   .||
Zfish   310 SDELYPAETLLSEIDEAFPEDVQPEYHHVFELRHTRVIWKNCLILGFTLFIGTGIQYCF---TRN 371

  Fly   431 VGSLGLDIFFTFTLACFTELPADTLLTVILDRFGRRWLACSSMVLSGVFSLLATVVP-------- 487
            :.......:|::.|...|...|...|.|.:||:|||.:...:.:::|:.|||...:.        
Zfish   372 LHIYSPHFYFSYFLRVLTGALACIFLCVTVDRYGRRGMLLLAAIITGLSSLLLLALTQYLHGGLV 436

  Fly   488 -----VGIYSA-ALAIMGRFFVNISYNIGLQWAAEVLPTVVRAQAVAFIHIMGYVASIIAPFVVY 546
                 ||:.|: |||::..||           .:||:||:||...:..|...|.:....:..:..
Zfish   437 LVLSVVGLLSSQALAMLSMFF-----------GSEVMPTIVRGGTLGLIMSAGCIGMAASSLMEL 490

  Fly   547 LANISQALPLIILGILGIIGGLLALLLPETLNHVLPQTLSDGE 589
            ..|....|..:|.....::..|..:||||:.:..||.:|.|||
Zfish   491 QNNGGYFLHHVIFASFAVLSVLCIMLLPESKHKPLPDSLKDGE 533

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG42269NP_648019.2 2A0119 80..552 CDD:273328 136/513 (27%)
MFS 206..545 CDD:119392 93/362 (26%)
slc22a31XP_699154.4 2A0119 12..527 CDD:273328 144/544 (26%)
MFS <347..518 CDD:119392 43/184 (23%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
11.000

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