DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42269 and Slc22a21

DIOPT Version :9

Sequence 1:	NP_648019.2	Gene:	CG42269 / 38689	FlyBaseID:	FBgn0259164	Length:	662	Species:	Drosophila melanogaster
Sequence 2:	NP_062697.1	Gene:	Slc22a21 / 56517	MGIID:	1929481	Length:	564	Species:	Mus musculus

Alignment Length:	539	Identity:	157/539 - (29%)
Similarity:	268/539 - (49%)	Gaps:	35/539 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    70 MDFDDILPLIGEFGRYQKLLFICMIPFSFFVAFVYFSQIFLTLIPEQHWCHVPELDGLDVEARLA 134
            :|:|::...:||:|.:|:|:|..:........|...|.:|||.||| |.|.:|:...|. .|...
Mouse     2 LDYDEVTAFLGEWGTFQRLIFFLLSASIIPNGFTGLSAVFLTAIPE-HRCRIPDTVNLS-SAWRN 64

  Fly   135 LSIPMTNGE----YNNCYMYDV----NYTDI-LAQGKVMADPKWPQVKCRHGWSYNFTEIPYATV 190
            .||||...:    ...|..|.:    |:::: |..|:.:...:..|..|..||.|: .:|..:|:
Mouse    65 HSIPMETKDGPEVPQKCRRYRLATIANFSELGLEPGRDVDLEQLEQENCLDGWEYD-KDIFLSTI 128

  Fly   191 ATEQNWVCDDAALPTYAQSIFFLGAIVGGLLFGWVADRFGRIPALIGTNMMGLLAGVGTAFVS-- 253
            .||.:.||.|........|.|::|.::|..:.|.::|||||...|..|..|    ..|.:|:.
Mouse   129 VTEWDLVCKDDWKAPLTTSFFYVGVLLGSFISGQLSDRFGRKNILFLTMAM----HTGFSFIQVF 189

  Fly   254 --NFWEFAIMRFFVGFAFDNCFTMMYILVLEYVGPKYRTFVANMSIAIFFTGAACLLPWIAYFLA 316
              ||..|.::...||....:.:...::|..|.:....|...|.:.:.|||.....:||..|||:.
Mouse   190 SVNFEMFTLLYTLVGMGHISNYVAAFVLGTEMLSKSVRIIFATLGVCIFFAFGFMVLPLFAYFIR 254

  Fly   317 DWKLLAIVTSAPLLLAIFTPFVVPESARWLVSQGKVDKAVGILKKLEKGNGRQV------PPQTY 375
            :|:.|.:..:.|.:|.....:.:|||.|||:|||::.:|..|::|..|.||...      |.:|.
Mouse   255 EWRRLLLAITLPGVLCGALWWFIPESPRWLISQGRIKEAEVIIRKAAKINGIVAPSTIFDPSETN 319

  Fly   376 QIFTDSCKRMQEQEAQNGKYSVLDLFKSPRLRRTTLLLIVIWMAISLVFDGHVRNVGSLGLDIFF 440
            ::..||.|:.|       .:.:.||.::|.:|..|::.|::|:.||:.:.|...:..:|..:|:.
Mouse   320 KLQDDSSKKPQ-------SHHIYDLVRTPNIRILTIMSIILWLTISVGYFGLSLDTPNLNGNIYV 377

  Fly   441 TFTLACFTELPADTLLTVILDRFGRRWLACSSMVLSGVFSLLATVVPVGIY--SAALAIMGRFFV 503
            ...|....|:||..|..::|....||:....|:.|.|...||..:||..::  |..|.::|:|.:
Mouse   378 NCFLLAAVEVPAYVLAWLLLQHVSRRYSMAGSLFLGGSVLLLVQLVPSDLHYLSTTLVMVGKFGI 442

  Fly   504 NISYNIGLQWAAEVLPTVVRAQAVAFIHIMGYVASIIAPFVVYLANISQALPLIILGILGIIGGL 568
            ..:|::...:.||:.|||||...|........:.||::|:.|||....:.||.|::|.|.|:..:
Mouse   443 TSAYSMVYVYTAELYPTVVRNMGVGVSSTASRLGSILSPYFVYLGAYDRRLPYILMGSLTILTAI 507

  Fly   569 LALLLPETLNHVLPQTLSD 587
            :.|..||:....||:|:.:
Mouse   508 ITLFFPESSGVSLPETIDE 526

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42269	NP_648019.2	2A0119	80..552	CDD:273328	143/492 (29%)
CG42269	NP_648019.2	MFS	206..545	CDD:119392	100/350 (29%)
Slc22a21	NP_062697.1	2A0119	12..523	CDD:273328	154/524 (29%)
		MFS	123..513	CDD:119392	117/400 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	532..564
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167843887
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9N9
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.850