DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42269 and SLC22A11

DIOPT Version :9

Sequence 1:	NP_648019.2	Gene:	CG42269 / 38689	FlyBaseID:	FBgn0259164	Length:	662	Species:	Drosophila melanogaster
Sequence 2:	NP_060954.1	Gene:	SLC22A11 / 55867	HGNCID:	18120	Length:	550	Species:	Homo sapiens

Alignment Length:	566	Identity:	157/566 - (27%)
Similarity:	246/566 - (43%)	Gaps:	67/566 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 FKKGQEMAGGNGSDSLPPSMDFDDILPLIGEFGRYQKLLFI--C-MIPFSFFVAFVYFSQIFLTL 112
            |.|..|.|||                  :|.|...|.|.||  | |||....:      :.|...
Human     3 FSKLLEQAGG------------------VGLFQTLQVLTFILPCLMIPSQMLL------ENFSAA 43

  Fly   113 IP-EQHWCHVPELD-------GLDVEARLALSIPM-TNGEYNNCYMYDVNYTDILAQGKVMADP- 167
            || .:.|.|:  ||       .:..:|.|.:|||. .|...:.|..:......:|       ||
Human    44 IPGHRCWTHM--LDNGSAVSTNMTPKALLTISIPPGPNQGPHQCRRFRQPQWQLL-------DPN 99

  Fly   168 ----KWPQV---KCRHGWSYN---FTEIPYATVATEQNWVCDDAALPTYAQSIFFLGAIVGGLLF 222
                .|.:.   .|..||.|:   ||    :|:..:.:.||....|...:||||..|.:||..::
Human   100 ATATSWSEADTEPCVDGWVYDRSVFT----STIVAKWDLVCSSQGLKPLSQSIFMSGILVGSFIW 160

  Fly   223 GWVADRFGRIPALIGTNMMGLLAGVGTAFVSNFWEFAIMRFFVGFAFDNCFTMMYILVLEYVGPK 287
            |.::.||||.|.|....:...:||..|.|...|..:..:||...|.....|.....|::|:....
Human   161 GLLSYRFGRKPMLSWCCLQLAVAGTSTIFAPTFVIYCGLRFVAAFGMAGIFLSSLTLMVEWTTTS 225

  Fly   288 YRTFVANMSIAIFFTGAACLLPWIAYFLADWKLLAIVTSAPLLLAIFTPFVVPESARWLVSQGKV 352
            .|.....:....|..|.|. |..:|:.|.||:.|.:..|.|........:.:|||||||:.:||.
Human   226 RRAVTMTVVGCAFSAGQAA-LGGLAFALRDWRTLQLAASVPFFAISLISWWLPESARWLIIKGKP 289

  Fly   353 DKAVGILKKLEKGNG-RQVPPQTYQIFTDSCKRMQEQEAQNGKYSVLDLFKSPRLRRTTLLLIVI 416
            |:|:..|:|:.:.|| ::....|.::...|.|  :|..:.....||||||..|.||..:..::|:
Human   290 DQALQELRKVARINGHKEAKNLTIEVLMSSVK--EEVASAKEPRSVLDLFCVPVLRWRSCAMLVV 352

  Fly   417 WMAISLVFDGHVRNVGSLGLDIFFTFTLACFTELPADTLLTVILDRFGRRWLACSSMVLSGVFSL 481
            ..::.:.:.|.|.::.|||.|||....|....:........::|...|||.:...|..::|:..|
Human   353 NFSLLISYYGLVFDLQSLGRDIFLLQALFGAVDFLGRATTALLLSFLGRRTIQAGSQAMAGLAIL 417

  Fly   482 LATVVPVGIYS--AALAIMGRFFVNISYNIGLQWAAEVLPTVVRAQAVAFIHIMGYVASIIAPFV 544
            ...:||..:.:  ...|::|:....||......:.||:.||.||..|...:|.:|.:.:::.|.:
Human   418 ANMLVPQDLQTLRVVFAVLGKGCFGISLTCLTIYKAELFPTPVRMTADGILHTVGRLGAMMGPLI 482

  Fly   545 VYLANISQALPLIILGILGIIGGLLAL-LLPETLNHVLPQTLSDGE 589
            :........||.::.|::.|...|:.| .||||....||.|:.|.|
Human   483 LMSRQALPLLPPLLYGVISIASSLVVLFFLPETQGLPLPDTIQDLE 528

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42269	NP_648019.2	2A0119	80..552	CDD:273328	136/497 (27%)
CG42269	NP_648019.2	MFS	206..545	CDD:119392	98/341 (29%)
SLC22A11	NP_060954.1	Sugar_tr	11..523	CDD:331684	150/551 (27%)
SLC22A11	NP_060954.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	531..550
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165153227
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.950